ʻO ka Simvastatin kahi lāʻau lapaʻau me nā waiwai lipid-hoʻohaʻahaʻa. E kiʻi i ka lāʻau lapaʻau me ka hoʻohana ʻana i ka synthesis kimia mai ka huahana o ka huina o ka enzymatic metabolism o Aspergillus terreus.
ʻO ka hoʻolālā kemika o ka waiwai he ʻano hana ole o ka lactone. Ma ka hoʻololiʻana biochemical, hele mai ka synthesis o cholesterol. ʻO ka hoʻohanaʻana i ka lāʻau lapaʻau e pale i ka hōʻiliʻili o nā lipids nui loa i ke kino.
ʻO nā molekule o ka waiwai e hoʻopiʻi i ka hoʻohaʻahaʻa i ka plasma o ka triglycerides, nā nui o ka atherogen o nā lipoproteins, a me ka pae o ka kolamu o ka nui. ʻO ka hapa ʻana o ke kāpili ʻana o ka lipher atherogen ma muli o ka pani ʻana o ka hoʻokumu ʻana o ka cholesterol i nā hepatocytes a me ka hoʻonui ʻana i ka nui o nā ʻōhua ʻoka no ka LDL i ka membrane pili, e alakaʻi i ka hoʻolaʻa a me ka hoʻohana ʻana iā LDL.
Hoʻonui pū ia i ka pae o ka lipoproteins density kiʻekiʻe, hoʻemi i ka haʻahaʻa o nā lipher atherogen i ka antiatherogenic a me ka pae o ka cholesterol free i nā hōʻuluʻulu antiatherogenic.
Wahi a nā hoʻokolohua lapaʻau, ʻaʻole ka hopena o ka lāʻau i ka mutular cellular. ʻO ka manawa o ka hoʻomaka ʻana i ka hopena therapeutic ʻO ka hoʻomaka ʻana o ka hopena he 12-14 lā, ʻoi ka hopena therapeutic kiʻekiʻe loa i hoʻokahi mahina ma hope mai o ka hoʻohana. E paʻa mau ka hopena me ka lōʻihi o ke kau ʻana. Inā hōʻea ʻoe i ka lawe ʻana i ka lāʻau lapaʻau, hoʻi ka pae o ka endogenous cholesterol i kona pae mua.
ʻO ka hui ʻana o ka lāʻau lapaʻau ka hōʻike ʻana i nā mea ikaika a Simvastatin a me nā mea kōkua.
Loaʻa i kēlā me kēia huahana ka nui o ka absorption a me ka bioavailability haʻahaʻa. Ke komo nei i ke koko, ka mea hoʻopili i ka albumin. Hoʻohālikelike ʻia ka ʻano ikaika o ka lāʻau lapaʻau e nā ʻano neʻe maʻamau biochemical.
Hoʻonui ka metabolv Simvastatin i nā hepatocytes. Loaʻa ia i ka hopena o ka "hele mua" ma o nā pili kelepona. Hōʻalo ka hele ʻana ma o ke kaomi ʻana (a hiki i 60%) ma ke ʻano o nā metabolite ʻole e hana. Hoʻokuʻu ʻia kekahi ʻāpana liʻiliʻi o nā waiwai e nā keiki ma kahi hana deactivated.
Nā hōʻailona no ka hoʻohana ʻana
Hoʻomaopopo ʻia ka hana me ka simvastatin e hoʻohaʻahaʻa i nā lipid koko, no ka mea, e pili ana ka lāʻau lapaʻau i nā lāʻau lapaʻau lipid-hoʻohaʻahaʻa.
Kau ʻia ka lāʻau lapaʻau no ka komo ʻana i ka lāʻau lapaʻau e hele ana, ka hoʻopaʻa ʻana iho o ka lāʻau i ka lāʻau.
ʻO nā hōʻailona no ka hoʻohana ʻana nā kūlana i hele pū ʻia e nā kolamu kiʻekiʻe a me nā lipher atherogenic.
I kēia mau maʻi ka komo ʻana i kēia:
- ʻO ka moku'āina o ka hypercholesterolemia mua me ka hiki ʻole o ka ikaika o ke ana hoʻomehana non-pharmacological i nā mea maʻi i hōʻeha ʻia no ka hoʻomohala ʻana i ka atherosclerosis coronary.
- ʻO ka hui pū ʻana o ka hypercholesterolemia a me hypertriglyceridemia, kahi kīnā paʻa ʻole me ka haʻahaʻa haʻahaʻa a me nā hana kino dosed.
- ʻO ka IHD no ka pale ʻana i ka hopena o ka make ma ke ʻano o ka coronary syndrome (i mea e hoʻolohi i ka holomua o ka coronary artery atherosclerosis), nā hana koko a kahe cerebral a me nā maʻi kahe neʻe i ka maʻi cerebral.
- ʻO ka hōʻemi i ka hopena o ka revascularization.
ʻO ka nui o ke ʻano o ka lāʻau lapaʻau he mau papa waha me ka nui o nā 10, 20 a me 40 milligrams. Kahi ʻia ka hopena o ka lāʻau no kēlā me kēia kanaka, i ke ʻano o nā ʻano o ke kino o kēlā kanaka.
Hoʻokomo ʻia ka lāʻau lapaʻau i ka papa inoa o nā lāʻau lapaʻau ʻaʻole i manaʻo ʻia no ka hoʻokō pilikino.
Nā ʻōkuhi no ka hoʻohana ʻana i ka simvastatin
Ma mua o ka hoʻomaka ʻana i ka maʻi, ua kuhikuhi ʻia ka mea maʻi i ka ʻai hypocholesterol maʻamau, pono e hoʻomau i ka pae no ke ʻano o ka papa lāʻau. Hoʻolālā ʻia ka papa simvastatin no ka hoʻoponopono waha. Pono ke kiʻi ʻia ka lāʻau i hoʻokahi manawa i kēlā me kēia 24 mau ahiahi o ke ahiahi, inu i nā nui o nā ʻano wai. I ka manawa lawe ʻana i ka lāʻau lapaʻau ʻaʻole pono e ʻai.
Koho ʻia ka lōʻihi o ke ʻano me Simvastatin e ke kauka maʻi.
Me ka hypercholesterolemia, ʻo ka hopena waiapau māla hopena ʻo 5-80 mg hoʻokahi. Inā ʻaʻohe maʻa ma kahi maʻa o kahi 40 mg, pono e hoʻololi ke ʻano. ʻO kēia ma muli o ka kiʻekiʻe myotoxicity o ka lāʻau lapaʻau ma loko o kahi iniha nui aʻe ma mua o 40 mg. Ua hōʻike ʻia ka nui o ka lāʻau therapeutic i nā maʻi i mālama ʻia me ka 40 mg maikaʻi ʻole. ʻO ka liʻiliʻi hoʻomaha therapeutic he 10 mg.
Palapala ʻia ka hoʻololi ʻana ʻana o ka Dose ma mua o hoʻokahi malama. Loaʻa nā maʻi hou i ka therapy me ka liʻiliʻi liʻiliʻi o ka mea.
I ka poʻe maʻi me ka genchastesterolemia genetic, ʻo ke kaila o ka simvastatin ka nui o 40 mg. Hoʻoikaika ʻia ka lā i kēlā me kēia lā i ʻelua mau pona. Ma ka hypercholesterolemia koʻikoʻi, ua hōʻike ʻia ke ʻano hypolipidemic therapy.
No ka mālamaʻana i nā mea maʻi me ka maʻi arter coronary a i ʻole ka hopena no ka hiki ke hoʻomohala ʻia o ka maʻi artery coronary, ʻike ʻia ka hopena therapeutic me ka hoʻohana ʻana i ka simvastatin mai 20 a 40 mg no 24 mau hola. Hoʻomaopopo ʻia e hoʻololi i ka maʻi ma mua o hoʻokahi mahina ma hope o ka hoʻomaka ʻana o ka hoʻohana. Hiki ke kūpono o ka mālamaʻana i 20 mg o ka mea.
Inā pono, e pālua i ka pālua.
Hoʻopili me nā lāʻau lapaʻau ʻē aʻe
ʻO ka lāʻau lapaʻau ka mea hoʻoikaika ikaika, lipid-hoʻohaʻahaʻa.
Ma kēia mea, maʻalahi ke komo nei i ka lāʻau i loko o nā hopena a me nā hopena o ka lāʻau lapaʻau me nā lāʻau ʻē aʻe.
ʻO ka neʻe o ka lā maʻamau o simvastatin i loko o ka poʻe e lawe nei i kekahi mau lāʻau lapaʻau ʻaʻole pono e oi aku ma mua o 10 mg.
ʻO kēlā mau lāʻau lapaʻau he immunosuppressants (cyclosporin); androgens synthetic (Danazole); nā paʻakau; ka hoʻomākaukau ʻana ma ka mana nicotinic;
No ka poʻe maʻi e lawe ana iā Amiodarone a me Verapamil, ʻaʻole pono o ka nui o ka lāʻau lapaʻau ma mua o 20 mg. I ka wā e mālama ai me Diltiazem, ʻo ka nui o ka simvastatin e 40 mg.
I nā poʻe maʻi o ka ʻelemakule kahiko, a me ka poʻe maʻi me ka peni ʻole a subcompensated renal gagal, ʻaʻohe pono e hoʻoponopono i ka ʻōpū. I ka poʻe maʻi me ka hiki ʻole i ka decompensated renal failed, me kahi hoʻohaʻahaʻa i ka hana ʻana i lalo o ka creatinine i emi iho ma mua o 30 milliliter, ʻaʻole pono ke kuhikuhi i ka lāʻau lapaʻau ma loko o kahi pōpō ʻoi aku ma mua o 10 mg. Inā pono e hoʻonui i ka dosis, e pono ka mālama ʻana i nā lapaʻau o kēia pūʻulu o nā maʻi.
ʻO ke kūlike me nā lāʻau lapaʻau e pono e ʻae me ke kauka. I ka manawa mua, pono e hōʻiliʻili pono ʻia ka mōʻaukala o ka mea maʻi a ua wehewehe pono ke ʻano o ka therapy concomitant.
Nā Hōʻeu Palapala Simvastatin
Ke lawe nei i ka lāʻau, hiki i kahi kikoʻī o nā hopena ʻino loa i loaʻa mai i ka mea maʻi.
ʻO ka hopena ʻino ma ka simvastatin he hilinaʻi i ka dosis.
ʻOi aku ka nui o ka lāʻau i lawe ʻia, ʻoi aku ka nui o ka hopena o ka hopena ʻaoʻao.
ʻO ka hopena ʻokoʻa e pili ana i ka simvastatin i loko:
- ʻO nā hopena o ka gastastopinal: ʻeha o ka ʻōpū, constipation a i ʻole ka maʻi ʻana, ka puhipuhi, maldigestion, malabsorption, ka ʻuwala me ka hoʻomau, maʻi ʻaʻai pancreatic, hepatosis a hepatitis, icteric syndrome, lipi ʻōpio.
- Mai ka ʻaoʻao o ka wahī: ka hopena o ka maʻi asthenic, ʻehaʻeha, paresthesia, dizziness, polyneuropathy, nā moe hiamoe, nā hana mnemonic impaired.
- Mai ka ʻaoʻao ʻaoʻao o ka muso ʻana: ka ʻūhā ʻana o ka aʻa a me ka twitching, nā huina hoʻokuʻi, nāʻu myasthenia gravis, nāwaliwali o ka naʻau, nā myopathy; rhabdomyolysis, ʻeha hōʻeha.
- Mai ka ʻōnaehana sensory: ka hopena o ka noʻonoʻo ʻono.
- ʻO ka maʻi hypersensitivity: ʻO ka edema o Quincke, rehe rheumatic, vasculitis, dermatomyositis, urticaria, pruritus, rash, hoʻonui i ka naʻau i ka radiation UV.
- Mai ka hemopoiesis: kahi hōʻemi o ka helu o nā platelets, eosinophils, he nui i ke kaila erythrocyte sedimentation, anemia.
- Mai ka ʻōnaehana musculoskeletal: arthritis, arthrosis, ʻāʻālua o nā eha
- Mai CCC: tachycardia, hoʻonui i ke koko.
- Rare hopena: ʻano hana i loko o nā kāne, alopecia.
ʻO ka hoʻopiʻi hoʻopilikia nui loa ka hopena o ka hoka o ka renal ma muli o ka nui o ka ejection o myoglobin ma muli o ka hōʻeha kino o ka wā o ka rhabdomyolysis.
Inā loaʻa kekahi o ko lākou mau hōʻailona, e hoʻomaopopo koke ʻoe i kāu kauka. Pono ke kauka hele e hoʻoponopono i nā ʻano o ka lāʻau.
Nā koho a me nā kaupalena e hoʻohana ʻia
ʻO kahi koho ka simvastatin i kahi palena nui loa.
ʻO kēia ke kumu i ka hopena o ka mea i loaʻa ka hopena no ke kino holoʻokoʻa, e kau ana i ka metabolism o nā loina.
Ma keʻano holoʻokoʻa, ʻaʻole palekana ka lāʻau lapaʻau inā pono ʻole ke kuhikuhi a hoʻohana ʻia.
ʻO nā kūlana aʻe e pili ana i ka hoʻohālike iā Simvastatin:
- kalaka o ke akea i kahi hana ikaika;
- ka hana nui o nā hana o ka ate o nā kumu ʻike ʻole;
- ka hui pū ʻana o Itraconazole, Ketoconazole, HAART, macrolides;
- maʻi ʻōiwi;
- hapai a me ka umauma;
- makahiki o na keiki;
- kolamu ʻole haʻahaʻa;
- lactase hemahema,
- kalakaʻawa kalawaʻi;
- hypersensitivity o ka mea hana a i ʻole nā mea kōkua?
- hypersensitivity i nā statins.
ʻAʻole hoʻohana ʻia ka hoʻohana ʻana o simvastatin i ka wā hāpai a me ka lactation. ʻO kēia ma muli o kaʻoiaʻiʻo ua loaʻa kahi hopena i ka teratogenic hopena. Eia kekahi, ʻo ke lāʻau lapaʻau e contraindicated ma ka umauma, no ka mea hiki iā ia ke komo i ka waiū.
Pono e pale ʻia nā wahine o ka hānau keiki ʻana mai ka wā hapai i ka wā mālama me Simvastatin.
I nā maʻi o ka poʻe ʻelemakule, ʻoi aku nei i nā wāhine, pono e kaupalena ʻia ka lāʻau lapaʻau.
Contraindicated ka lāʻau lapaʻau i nā keiki.
I ka hoʻomaka ʻana o ka hoʻōla me ka simvastatin, kahi hoʻolōʻihi i ka nui o ka nui o nā transaminases i hoʻomaopopo ʻia. Ma mua o ka hoʻomaka ʻana i ka hoʻokipa a i ka wā o ka holoʻokoʻa holoʻokoʻa, pono ia e kiaʻi pinepine i ka hana naʻau.
Me ka hoʻonui ʻana o ka nui o nā transaminases e ʻoi aku ma mua o 3 mau manawa, pono e hoʻokuʻu ʻia nā lāʻau me Simvastatin.
ʻO nā hiʻohiʻona o ka hoʻohana ʻana i ka simvastatin
Pono ke ʻano o ka lāʻau lapaʻau e nā lāʻau lapaʻau a i ʻole cardiologist. ʻO Simvastatin kahi lāʻau lapaʻau o kahi hanauna hou, nā ʻōlelo kauoha e hoʻohana ai no ka hoʻohana ʻana i nā hiʻohiʻona o nā lāʻau lapaʻau, i hoʻoholo ai i ke kumukūʻai kiʻekiʻe o ka mālama maʻi.
Kūkulu ka huahana i ka hoʻouluulu lāʻau lapaʻau honua "Zentiva", aia i ke Czech Republic. Hana ka mea hana hana i kahi lāʻau lapaʻau inoa inoa maʻamau.
ʻO ka lāʻau lapaʻau wikiwiki a hoʻohaʻahaʻa hoʻi i ka cholesterol, e hoʻolilo i ka hoʻolilo ʻana a me ka hoʻomaikaʻi nui ʻana i ke kūlana o nā mea maʻi me ka lipid metabolid impaired.
ʻO ke ʻano lāʻau ka lāʻau lapaʻau.
I mea e mālama ai i ke kālā, hiki iā ʻoe ke kūʻai i kahi mea hou no ka lāʻau lapaʻau. ʻO nā hui koke o Simvastatin he Aterostat, Zokor, Simvakard, etc. Kūpono paha nā inoa i ka mea hana.
ʻO ka hanaʻino o ka lāʻau lapaʻau, i ka hapa nui, ma muli o ka hoʻonāukiuki ʻana o ka noho aliʻi ʻana a me ka doses.
Ma ka holoʻokoʻa, ua loaʻa ka pahuhopu i nā pane pane maikaʻi a me ka nui o ka manaʻo kūpono mai nā poʻe loea i loko o ka lāʻau lapaʻau. ʻO ka lāʻau lapaʻau he hanauna hou o ka hana kiʻekiʻe a me ka liʻiliʻi loa.
Eia nō naʻe, pono e nānā ʻia nā kuhikuhi a pau no ka hoʻohana ʻana. Lā ʻia ka inu ʻawaʻī i ka wā o ke ʻano. He mea nui i ke kāohi i ka pae o ka glycemia i ka wā e mālama ai i nā mea maʻi me ka maʻi maʻi maʻi, ʻoiai ua pili nā stins i nā pae kōʻai koko.
ʻO ka hoʻokokokeʻana i ka mālamaʻana i ka hypercholesterolemia a me ka atherosclerosis e holo piha. ʻO ka lawe ʻana iā Simvastatin e hui pū me ka launa ʻano maʻamau a me ka hana kino kino dosed maʻamau.
Me ka like ʻole o ka hoʻouluulu ʻana me ka Simvastatin, hiki i nā pūʻulu o nā lāʻau lapaʻau ke kuhikuhi ʻia:
- ʻO nā luna ʻē aʻe o ka hui statin ʻo Atorvastatin, Rosuvastatin, Rosulip, etc.
- Hoʻopuka ʻana.
- ʻO ka hoʻomākaukau ʻana ma ka mana Nicotinic.
- ʻO nā huehue momona Omega.
Loaʻa i kēlā me kēia hui o ka lāʻau lapaʻau a i ʻole kekahi meaola. ʻO nā omega-3 a me nā Omega-6 wale nō nā mea e palekana. Loaʻa lākou i ka hana pale. Me ko lākou hoʻomaka mua ʻana i ka meaʻai, ua hoʻemi ʻia ka hopena o ka make ma ke ʻano o ka pilikia cardiac a me ka vascular e 40%. Aia kahi hoʻomaʻemaʻe i nā kīʻaha koko mai nā atherosclerotic plam a me ka hoʻemi ʻana o ka pae o ka lipher atherogenic.
Kūlike ke kumukūʻai ma Lūkini ma muli o ke kaulahao a me ka lā kūʻai aku. Loaʻa nā loiloi maikaʻi i kahi lāʻau lapaʻau i hana ʻia e Czech. Hoʻomaka ke kumukūʻai ma Lūkia mai 93 mau rubles.
Hoʻolako ka ʻike e pili ana i ka lāʻau lapaʻau Simvastatin i ke wikiō ma kēia ʻatikala.
