I nā mau makahiki he ʻelua i hala iho nei, ua hoʻonui nui ʻia ka ulu ʻana o ka maʻi diabetes ma ka aneane he iwakālua mau manawa. ʻAʻole kēia helu helu i nā maʻi i ʻike ʻole i ko lākou maʻi. ʻO ka mea maʻamau ka mea maʻamau diabetes type 2, non-insulin dependant.
He maʻi nui lākou i ka ʻelemakule. ʻO ke ʻano maʻi maʻi mua e pili ana i nā kānaka i kona wā ʻōpio, ʻeha nā keiki i laila, a aia nā maʻi o ka diabetes congenital. Inā ʻaʻole i nā inikini insulin, ʻaʻole hiki iā lākou ke hana i hoʻokahi lā.
ʻO ka hoʻokomo pūʻana i ka insulin e hele pū me nā hopena alerine, he insensitivity i ka lāʻau lapaʻau. Ke alakaʻi nei kēia mau mea i ka ʻimi no nā ala hou, ʻo ia kekahi o ka mālama ʻana i ka maʻi type 1 me nā cell stem.
Nā kumu o ke kanesa o ke ʻano
I ke ʻano maʻi diabetes type 1, hoʻomohala ka hemahema o ka insulin ma muli o ka make o nā kelena beta e loaʻa ana i nā mokupuni pancreatic o Langerhans. Hiki i kēia ke kumu.
- Hānau a meakanakūne predisposition genetic.
- ʻO nā kūmole Autoimmune.
- ʻO nā maʻi maʻi - tigel, rubella, cytomegalovirus, chickenpox, Coxsackie virus, mumps.
- ʻO ke kūlana paʻakikī-psycho-koʻikoʻi.
- ʻO ka hana hoʻonāʻeha i ka pancreas.
I kēia mau hihia a pau, ʻike ʻia nā cell pancreatic he haole, a ua luku ʻia ka ʻōnaehana pale iā lākou. Hoemi ʻia ka ʻike o ka insulin, piʻi ke kiʻekiʻe o ke koko. Ke alakaʻi nei kēia i kahi ulu e pili ana i ka hōʻailona: ka makewai, ka nui o ka urination, ka palupalu nui, ka pōloli, ka nui o ke kaumaha, nā hōʻeha a me nā moe hiamoe.
Inā ʻaʻole hoʻomaka ka mea maʻi e mālama ʻia me ka insulin, hoʻomohala ʻo ia i kahi maʻi maʻi maʻi maʻi. Eia kekahi, loaʻa nā pōʻino i ke ʻano o nā hoʻopiʻi - nā hōʻeha, ka hōʻeha ʻana o ka puʻuwai, ka pohō o ka ʻike ma ka diabetes mellitus, microangiopathy me ka hoʻomohala ʻana i nā gangrene, neuropathy a me nā alelo kūloko me ka hana ʻole o ka renal.
ʻO nā ala no ka mālamaʻana i ka maʻi maʻi type 1
I kēia lā, ua manaʻo ʻia ka maʻi diabetes. ʻO ka Therapy ka mālama ʻana i nā pae kūlohelohe i loko o ka paena i ʻōlelo ʻia ma o nā haka a me nā inikini insulin. Hiki paha i ke kūlana o ka mea maʻi me ka ʻoluʻolu kūpono, akā ʻaʻole hiki ke hoʻihoʻi ʻia nā mea maʻi pancreatic.
Ua hoʻāʻo ʻia ka hoʻāʻo ʻana iā pancreatic, akā ʻaʻole i ʻike ʻia ka pōmaikaʻi. Hoʻololi ʻia nā insulins a pau e ka inikua, ʻoiai ma lalo o ka mana o ka waikawa hydrochloric a me nā pepsin mai i ka wai momona, ua luku ʻia lākou. ʻO kekahi o nā koho no ka hoʻokele he hemment of a pump pump.
Ma ka mālama ʻia ʻana o ka maʻi maʻi, ua ʻike ʻia nā hana hou e hōʻike ana i nā hopena hōʻoiaʻiʻo.
- ʻO ka vaksin DNA.
- Hoʻokomo hou ʻana i ka T-lymphocytes.
- Plasmapheresis
- Hoʻolahalaha cell cell.
ʻO kahi ala hou kahi ka hoʻomohalaʻana o ka DNA - he kanulau e pale i ka hoʻomakeʻa ʻana ma ka pae DNA, ʻoiai e pau ka luku ʻana i nā pūmake pancreatic. Aia kēia ala i ke kahua o nā hoʻokolohua lapaʻau, palekana i kona palekana a me ka hopena lōʻihi.
Ke hoʻāʻo nei lākou e hana i kahi hana ma ka ʻōnaehana pale me ke kōkua o nā ʻōnaehana reprogrammed kūikawā, kahi, e like me nā mea hoʻomohala, hiki ke pale aku i nā ʻekena insulin i loko o ka pancreas.
No kēia mea, ua lawe ʻia nā T-lymphocytes, i loko o nā kūlana hana nūnū e hoʻololi ʻia ko lākou mau ʻano i ke ʻano e pau ai lākou i ka hoʻopau ʻana i nā cell beta pancreatic. A ma hope o ka hoʻi ʻana i ke koko o ka mea maʻi, hoʻomaka nā T-lymphocytes e kūkulu hou i nā ʻaoʻao ʻē aʻe o ka ʻōnaehana.
ʻO kekahi o kēia mau ala, plasmapheresis, e kōkua i ka hoʻomaʻemaʻe i ke koko o nā kahe i loko o ka protein, me nā antigens a me nā mea luku o ka ʻōnaehana. Hōʻalo ke koko ma kahi mea hana kūikawā pono hoʻi e hoʻi i ka moe vascular.
ʻO ka lāʻau lapaʻau lāʻau Stem Cell
Kūpono ka nui o nā hua lāʻau i loko, nā mea wehe ʻole i loaʻa i loko o ka hua ʻai. Ma kahi maʻamau, inā hōʻino kekahi huelo, hoʻokuʻu ʻia lākou i loko o ke koko a, ma ka wahi o ka pōʻino, loaʻa nā ʻāpana o kahi maʻi maʻi.
Hoʻohana ʻia ka lāʻau cell Stem e mālama ai:
- ʻO ka Sclerosis lehulehu.
- Ka pōʻino o Cerebrovascular.
- ʻO ka maʻi Alzheimer.
- ʻArdlelo haʻo (ʻaʻole no ka genetic kumu).
- Palebral palsy.
- Haki puʻuwai, angina pectoris.
- Kahi ʻo Limb.
- Ke wehe nei i ka endarteritis.
- Hoʻokomo ʻia a me nā maʻi a me nā degenerative.
- Immunodefue.
- ʻO ka maʻi Parkinsinson.
- ʻO Psoriasis a me ka systemic lupus erythematosus.
- ʻO ka hepatitis a me ka pohō hemahema.
- No ka hoʻomaikaʻi.
Ua hoʻomohala kahi ʻano hana no ka mālama ʻana i ka maʻi mellitus type 1 me nā cell stem a me nā loiloi e pili ana i ia mea e hāʻawi ai i ke kumu no ka manaʻo like. ʻO ka hiʻona nui o ke ʻano:
- Lawe ʻia ka hua manu mai ka sternum a iʻa femur. No ka hana ʻana i kēia, lawe i kāna pā pāna me ka hoʻohana ʻana i kahi pono kūikawā.
- A ua hoʻopaʻa ʻia kēia mau sela, ua kekele kekahi o lākou no kēia mau hana, ua waiho ʻia ke koena i loko o kahi ʻano incubator a mai ka iwakālua tausani i loko o ʻelua mau mahina a lākou e ulu ai a hiki i 250 miliona.
- Hāʻawi ʻia nā selu i loaʻa i loko o ka mea maʻi ma o ka catheter i loko o ka pancreas.
Hiki ke hana ʻia kēia hana ma lalo o ke kūloko kūloko. A e like me nā loiloi o nā maʻi, mai ka hoʻomaka ʻana o ka ʻoihana e manaʻo nei lākou i ka piʻi ʻana o ka wela ma ka pancreas. Inā ʻaʻole hiki ke lawelawe ma ka catheter, hiki i nā mea pili ke komo i ke kino ma o ka infravenous infusion.
Pono a 50 mau lā no nā poʻe hoʻomaka e hoʻomaka i ke kaʻina hana hōʻoki o ka pancreas. I kēia manawa, hele mai nā loli like i ka pancreas:
- Hoʻololi ʻia nā ʻōpala i nā pōpoki pili i nā hua lāʻau.
- Hoʻomaka nā cell hou i ka hana ʻana o ka insulin.
- Hoʻokomo ʻia nā kīʻaha koko hou (nā lāʻau kūikawā e hoʻomaikaʻi i ka angiogenesis).
Ma hope o ʻekolu mahina, e loiloi i nā hopena. Wahi a nā mea kākau o kēia ʻano a me nā hopena i loaʻa i nā haukapila o ʻEulopa, uaʻikeʻia nā maʻi me ka maʻi diabetes mellitus, e hoʻomaka ka emi ʻana o ke koena o ke koko, e ʻae ana i ka hōʻemi o ka maʻa o ka insulin. Hoʻomau nā mākaukau a me nā ʻano o ka hemoglobin glycated i loko o ke koko.
Hoʻomaopopo ka lāʻau cell stem no ka maʻi maʻi i nā hopena maikaʻi me nā hoʻopiʻi i hoʻomaka. Me ka polyneuropathy, ka wāwae maʻi maʻi, hiki ke hoʻopaʻa ʻia i nā ʻona ke komo i ka lesion. I ka manawa like, hoʻomaka ke kahe o ke koko a me ka hoʻōla o nā neʻe e hoʻōla, hoʻōla ʻo nā ʻopa trophic.
Ke hoʻohui i ka hopena, ua noi ʻia kahi papa hana o ke lawelawe. Hoʻololi ʻia ka pīpī cell stem iʻeono mau mahina ma hope iho. I kēia hihia, ua hoʻohana ʻia nā mea i lawe ʻia i loko o ka hālāwai mua.
Wahi a nā kauka e mālama i nā pūliki olakino me ka maʻi diabetes, ʻike ʻia nā hopena ma kahi o ka hapalua o nā mea maʻi, a loaʻa lākou i ka loaʻa ʻana o ke kala he lōʻihi o ka maʻi mellitus - ma kahi o hoʻokahi a me ka hapa. Aia i ka hōʻike e pili ana i nā hihia no ka hōʻole ʻia o ka insulin a hiki i ʻekolu mau makahiki.
Nā hopena hopena o nā cell stem
ʻO ka pilikia nui ma ka hānō cell therapy no ka maʻi maʻamau o ka maʻi 1 ka mea, e like me ka pau ʻana o ka hoʻolālā, ka maʻi diabetes-dependant e pili ana i nā maʻi autoimmune.
I ka manawa e loaʻa ai i nā selela ke kīhili i nā ʻāpana o nā pona insulin o ka pancreas, hoʻomaka ka ʻōnaehana pale i ka hoʻouka kaua ʻana iā lākou e like me ka wā ma mua, i ka paʻakikī ʻana o kā lākou hana.
I mea e hōʻemi ai i ka hōʻole ʻana, hoʻohana ʻia nā lāʻau e hoʻopau ai i ka pale ʻole. I kēlā mau ʻano, hiki i nā hoʻopiʻi:
- hoʻonui i ka hopena o ka hopena o ke kuʻuna;
- nuala, holo koke
- me ka hoʻopuka ʻana o nā immunosuppressants, hiki i ka hāʻule o ka lauoho;
- lilo ke kino i pale mai i nā maʻi;
- hiki ke hoʻokaʻawale ʻia nā kuleana kīnā ʻole, e alakaʻi i nā hana kūlohelohe.
Ua noi aku nā poʻe ʻepekema ʻAmelika a me Iapania i nā lāʻau lapaʻau e hoʻololi i ke ʻano me ka hoʻopuka ʻana o nā hua lāʻau ʻaʻole i loko o ka lapalapa pancreatic, akā i loko o ka ate a ma lalo o ka lawe ʻana o nā pūpū. I kēia mau wahi, he mea liʻiliʻi lākou i ka luku ʻia e nā pūnaehana pale mai.
Ma lalo hoʻi o ka hoʻomohala ʻana, kahi ala o ka hui pū ʻana - genetic a me cellular. Hoʻokomo ʻia kekahi ʻano i loko o ka pūhā huaʻu e ka ʻenehana genetic, ka mea e hoʻoulu ai i kona hoʻololi ʻia i loko o kahi cell beta maʻamau; I kēia hihia, ʻaʻole iki ka pane o ka pale mai.
I ka wā o ka hoʻohana ʻana, e pau ka hoʻopau ʻana i ka uahi. ʻO ka mea mua nā meaʻaiʻai a me nā hana kino dosed.
ʻO ke hoʻololi i ka cell Stem he wahi hoʻohiki i ka mālama ʻana i ka maʻi maʻi. Hiki ke hoʻoholo ʻia kēia aʻe.
- Ua hōʻike ke ʻano o nā cell-cell i ke kūpono o kēia ʻano i ka mālama ʻana i ka maʻi mellitus type 1, e hoʻemi ana i ka nui o ka insulin.
- Loaʻa kahi hopena maikaʻi loa no ka mālama ʻana i nā hoʻopiʻi o ke a me ka ʻike ʻana i ka ʻike.
- ʻOi aku ka maikaʻi o ka diabetes mellitus no ka type 2 non-insulin, ʻoi aku ka maikaʻi o ke kala ʻana.
- ʻOiai nā loiloi kūpono a i wehewehe ʻia e ka endocrinologists (ʻo ka hapa nui o ka haole) nā hopena o ka lapaʻau, ʻaʻole i noiʻi ʻia kēia ʻano.
ʻO ke wikiō i kēia ʻatikala e kamaʻilio hou aku e pili ana i ka mālama ʻana i ka maʻi diabetes me nā cell stem.
