Onglisa - kahi lāʻau lapaʻau no ka maʻi maʻi o ka hanauna hou

ʻO Onglisa kekahi o nā ʻelele o kahi pūʻulu o nā hui hou hypoglycemic, DPP-4 inhibitors. ʻO ka lāʻau lapaʻau ka loaʻa kālā kūlike loa o ka hana mai nā papa antidiabetic ʻē aʻe. I ka hopena o ka hana kūpono, ua hoʻohālikelike ʻo Ongliza i nā ʻano kuʻuna; i nā ʻōlelo palekana o ka hoʻohana ʻana, ua nui loa ia ma mua o lākou. Eia kekahi, he hopena maikaʻi ka lāʻau lapaʻau i nā mea e pili ana, e hoʻolohi ana i ka holomua o ka maʻi diabetes a me ka hoʻomohala ʻana o nā pane.

Manaʻo nā kānaka ʻepekema ʻo ke kūkulu ʻana o kēia mau inhibitors ke hana koʻikoʻi nui i ka mālama ʻana i ka maʻi maʻi maʻi. Ua manaʻo ʻia ka loaʻa hou ʻana o ka lāʻau lapaʻau i hiki ke lōʻihi e hoʻihoʻi i ka hana pancreatic nalowale.

Heaha ka laau lapaau Onglisa i manaoia ai?

Hōʻike ʻia ka maʻi diabetes type 2 e ka hoʻemi ʻana o ka naʻau o nā ʻāpana pancreatic i ka glucose, kahi hoʻolā manawa i ka hoʻomaka mua o ka synthesis o ka insulin (i ka pane ʻana i nā meaʻai kākāia). Me ka hoʻonui ʻana o ka lōʻihi o ka maʻi, ua emi iki ka lua o ka hana ʻana o ka hormone ulu. Ke manaʻoʻiʻo ia ka kumu nui o ka hana maikaʻi ʻole o nā hana beta e hoʻoulu ai i ka insulin he hapa o ka incretins. ʻO kēia nā mau peptides e hoʻoulu ai i ka ʻōlelo pilikino o ka haki, ua hoʻohālikelike ʻia lākou i ka pane ʻana o ka pehu o ka glucose i loko o ke koko.

Hoʻopau ʻo Onglisa i ka hana a ka hoʻonaninani DPP-4, pono pono no ka uhaʻi ʻana o nā hua pane. ʻO ka hopena, noho lākou i loko o ke koko lōʻihi, ʻo ia ka mea e hoʻāla ʻia ka insulin ma kahi nui ma mua o ka maʻamau. E kōkua kēia hopena i ka hoʻoponopono ʻana i ka glycemia a ma luna o ka ʻōpū ʻole, a ma hope o ka ʻai ʻana, lawe mai i ka pancreas pale ʻole i ka physiological. Ma hope o ke koho ʻana iā Onglisa, ua hoʻohālikelike ʻia ka hemoglobin glycated i ka poʻe maʻi ma ka 1.7%.

Kahi ʻia ka hana o Onglises e pili ana i ka hoʻonui ʻia ʻana o ka hana o kāna iho ponoi, ʻo ka lāʻau lapaʻau ka hoʻonui ʻana i ko lākou kao i loko o ke koko ma o ka manawa ma mua o 2 mau manawa. Ke hele nei ke glycemia ma muli o ka maʻamau, ua hoʻoki ka nui o nā incretins i mea e hoʻopilikia ai i ka synt synthesis. Ma kēia mea, ʻaʻohe paʻakikī o ka hypoglycemia i nā maʻi maʻi e lawe nei i ka lāʻau. Eia nō hoʻi, ʻo ka lanakila kūpono ʻole o Onglisa ka pau ʻole o kona hopena i ke kaupaona a hiki i ka lawe ʻana me nā papa ʻai haʻahaʻa e loaʻa ai.

ʻO ka maʻi maʻi a me nā hoʻohaʻahaʻa manaʻo e hana ia i ka wā ma mua

• Ka hana maʻamau o ke kō -95%
• Hoʻokuʻuina o ka pua thrombosis - 70%
• Hoʻopau i kahi puʻuwai ikaika -90%
• Hoʻopau i ke kiʻekiʻe o ke koko - 92%
• ʻO ka hoʻonuiʻana i ka ikehu i ka wā, hoʻomaikaʻi i ka hiamoe i ka pō -97%

Ma kahi o ka hana nui, loaʻa iā Onglisa kekahi hopena maikaʻi i ke kino.

1. ʻO ka lāʻau lapaʻau e hōʻemi i ka helu o ka glucose i loko o nā palapu i loko o ke kahe wai, e kōkua ai i ka hoʻemi ʻana i ka pale ʻana i ka diabetes insulin a me ke kō ma hope o ka ʻai.
2. Hoʻokomo ʻia i ka hoʻoponopono ʻana o ka ʻai ʻai. Wahi a nā maʻi maʻi, e hoʻolako ʻo Onglisa i ka piha o ka piha, kahi mea nui loa no nā maʻi maʻi me ka hiʻona.
3. ʻAʻole e like me ka hoʻomākaukau ʻana o ka sulfonylurea, ka mea e hoʻonui ai i nā synthesis o ka insulin, ʻaʻole ʻino o Onglisa i nā pū beta. Ua hōʻike ʻia nā haʻawina ʻaʻole wale e luku wale i nā cell pancreatic, akā, ma ke ʻano ke pale aku nei, e pale aku a hoʻonui i ko lākou helu.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Kuhi ʻia ka lāʻau lāʻau i ʻAmelika Hui Pū ʻIa e ka hui ʻo Anglo-Swedia AstraZeneca. Hiki ke hoʻopaʻa ʻia nā papa ʻē aʻe i Italia a i ʻole ka UK. I ka pākauana o 3 mau kipi o ke kaʻa o 10 papa ma kēlā me kēia a me ke kuhikuhi no ka hoʻohana.

ʻO ka mea ikaika a me ka lāʻau lapaʻau he saxagliptin. ʻO kēia ka mea hou o nā DPP-4 inhibitors o kēia manawa; i komo i ka mākeke ma 2009. E like me nā mea kōkua, lactose, cellulose, magnesium stearate, sodium croscarmellose, ʻoni wau.

ʻO Onglisa he 2 mau dosages - 2.5; 5 mg Nā ʻāpana ʻōpala 2.5 mg maʻa, hiki ke hoʻokaʻawale ke ʻano lāʻau lapaʻau mua e nā ʻatikala 2.5 a me 4214 ma kēlā me kēia ʻaoʻao o ka pā. ʻO Onglisa 5 mg ʻaniʻulaʻula a ʻulaʻula, i hōʻailona ʻia me nā helu 5 a me 4215.

Pono e kūʻai ʻia ka lāʻau lapaʻau e ke kūʻai aku ʻana, akā ʻaʻole ʻike ʻia kēia kūlana i nā lāʻau lapaʻau āpau. Kūʻai nui ke kumukūʻai o Onglizu - ma kahi o 1900 mau rubles. i kēlā me kēia pā. I ka 2015, ua hoʻokomo ʻia ka saxagliptin i ka papa inoa o nā Vital a me nā Pono Pono, no laila hiki i nā mea maʻi maʻi papa inoa ke hoʻāʻo e kiʻi i kēia mau peni manuahi. ʻAʻohe o generanne Ongliza no laila e hāʻawi pono i ka lāʻau lapaʻau mua.

Pehea e lawe ai

ʻOnglisa i ʻōlelo ʻia no ka maʻi maʻi 2. Pono e hoʻōla me ka hoʻomaʻamaʻa ʻole i ka meaʻai a me ka hoʻomaʻamaʻa. Mai poina e hana mālie ana ka lāʻau lapaʻau. Me ka hoʻohana ʻole ʻana o nā kalapona a me ke ʻano passive, ʻaʻole hiki iā ia ke hāʻawi i ka uku i koi ʻia no ka maʻi maʻi.

ʻO ka bioavailability o saxagliptin he 75%, ka nui o ka piʻi ʻana o kahi mea i loko o ke koko i nānā ʻia ma hope o 150 mau minuke. Hoʻonui ka hopena o ka lāʻau i ka liʻiliʻi o 24 mau hola, no laila ʻaʻole pono ia e lawe i kāna kōʻai me ka meaʻai. Aia nā papa i loko o kahi kiʻiʻoniʻoni, ʻaʻole hiki ke wāwahi a ʻoki ʻia.

ʻO ka papa lāʻau i ʻōlelo ʻia i kēlā me kēia lā he 5 mg. No nā mea maʻi me nā maʻi ʻōlohelohe a me ka piha o ka hepatic, ʻaʻole pono ka hoʻoponopono ʻana.

ʻOkoʻa nā haʻahaʻa haʻahaʻa (2.5 mg):

• me ka pani ʻole ʻana me GFR <50. Inā kānalua ka maʻi o ka pēpē, e hōʻike ʻia i ka hoʻokolokolo o kā lākou hana;
• no ka manawa iki, inā pono, ka hoʻokomo o kekahi mau laʻa, antiviral, antifungal agents, kā lākou papa inoa holoʻokoʻa i hōʻike ʻia i nā kauoha.

Hoʻohālikelike Kahumoku

Arkady Alexandrovich

Endocrinologist me kaʻike

E nīnau i ka mea loea

Inā poina ua ka mea maʻi hānai i ka lalau, hiki iā ʻoe ke inu i ka lā. Kuhi ʻia ka ʻimi i ka lā aʻe e pāpā ʻia e ka ʻōlelo. ʻAʻole hoʻomaikaʻi kekahi overdose i ka kaohi o ka maʻi diabetes, akā ʻaʻole ia e hoʻohuli i kahi pōpilikia koʻikoʻi. ʻAʻole i loaʻa kekahi hopena o nā mea hoʻonā a me kahi hoʻohana hoʻokahi o 400 mg o ka saxagliptin.

ʻO nā maʻi a me nā hōʻeha

ʻAʻole ʻo Ongliz i koho:

1. I ka wā hāpai, lactation. Ka hopena o ka lāʻau lapaʻau i ka hoʻomohala ʻana o ka maʻa, ʻaʻole i aʻo ʻia ka hopena i loko o ka waiū.
2. Inā liʻiliʻi ka mea maʻi ma lalo o ka 18 makahiki. ʻAʻohe ʻike palekana e pili ana i ka nele o ka noiʻi e pili ana i nā keiki.
3. Inā kū ʻia nā hopena hypersensitivity e pili ana i ka saxagliptin, i nā lāʻau ʻē aʻe mai ka hui like ʻana, nā mea kōkua o ka papa. Wahi a ka mea hana, ʻo 1.5% o ka loaʻa o ka hopena e like me ka 1.5%. ʻAʻole lākou i koi ʻia i ke kau ʻana o ka mea maʻi ma kahi waihona olakino a ʻaʻole hoʻoweliweli lākou i ke ola.
4. Me ka intolerance lactose.
5. ʻO nā mea maʻi i hoʻōki ʻole i ka synthesis o kā lākou insulin (type 1 diabetes, pancreatic surgery).

ʻO ka manawa maʻamau, ua hoʻololi ʻia ka lāʻau lapaʻau me ka insulin therapy no ka ketoacidosis koʻikoʻi, nā hana hōʻeha a me nā hōʻeha.

ʻO ʻOnglisa kahi kūlana kiʻekiʻe. ʻO kēia kekahi o nā lāʻau lapaʻau liʻiliʻi antidiabetic i loaʻa ʻole nā ​​hopena pili ʻole. E like me nā hualoaʻa o nā noiʻi i nā hana ʻino i ka poʻe maʻi me ka saxagliptin, ua nui nā mea e like me ka pūʻulu mana e lawe nei i ka placebo. Eia nō naʻe, ʻo ka ʻōlelo pili no ka hoʻohana ʻana e pili ana i nā pilikia a pau i hālāwai me nā maʻi: ka hanu a me ka urinary tract, maʻi ʻana, ka maʻi ʻeha, ka luaʻi, ka ʻeha o ka ʻōpū, ke kaumaha, ka ʻehaʻeha.

Hoʻohana me nā lāʻau lapaʻau ʻē aʻe

No ka paleʻana i ka nui o nā hoʻopiʻi o ka maʻi diabetes i nā miliona o nā maʻi, nā lāʻau hou a me nā hoʻoponopono hoʻoponopono hou i hoʻokomo ʻia i loko o ka hoʻomaʻamaʻa hauka. Hoʻomaopopo ka hana maʻalahi i ke ʻano o ka metformin + loli hoʻololi. Inā lawa ʻole kēia kete, hoʻomaka e hoʻohui i nā lāʻau lapaʻau: hoʻohui i kekahi o nā lāʻau lapaʻau i ʻae ʻia i ka lāʻau i paʻa.

Eia naʻe, ʻaʻole palekana āpau a me ka maikaʻi:

ʻO ʻOnglisa ma ka ʻōlelo o ka hana like he kūlike me nā lāʻau lapaʻau i luna, a i ka pili o ka palekana a me ka liʻiliʻi o nā contraindications, ʻoi aku ka nui o nā mea āpau, no laila ke manaʻo ʻia e hoʻonui ʻia ka maʻi i nā maʻi.

Ua ae ka Lūkini Endocrinologists i hoʻohana ʻia i ka hoʻohana ʻana o nā DPP-4 inhibitors i hui pū me ka metformin e like me ka laina mua o ka mālama maʻi no ka maʻi maʻi maʻi. ʻAʻole like kēia mau lāʻau i ka hypoglycemia, hoʻopilikia i ke kumu o ke koko kiʻekiʻe mai nā kihi ʻē aʻe: pili lākou i ka pale ʻana i ka insulin a me ka hana cell cell.

E hoʻāʻo e hoʻomaʻamaʻa ʻia ka hoʻoponopono lāʻau, ʻo ka mea hana like i hana iā Combogliz Prolong. Aia i nā papa papa he 500 a 1000 mg o metformin hoʻomake-hoʻokuʻu a me 2.5 a i ʻole 5 mg o ka saxagliptin. ʻO ke kumukūʻai o kahi ʻāpana kālā ma kahi o 3300 rubles. ʻO kahi hui piha o ka lāʻau lapaʻau ka hui pū ʻana o Ongliza a me Glucofage Long, e uku ʻia hoʻokahi tausani o nā rubles.

Inā ʻaʻole e hāʻawi i nā lāʻau ʻelua i ka nui loa ma ka hopena i makemake ʻia no ka diabetes mellitus, ae ʻae ʻia e hoʻohui i ka sulfonylureas, glitazones, insulin i ka hoʻoponopono.

Hiki paha ke hoʻololi i kahi mea

ʻO ʻOnglisa wale nō ka lāʻau Saxagliptin i kēia lā. ʻOiai nui loa ke kamaʻilio e pili ana i ke ʻano o nā analogue maʻalahi, ʻoiai ke pale nei nā patent i ka hopena hou no nā lāʻau hou, ʻo ia ka mea e papa ʻole ai i ke kope ʻana i ka mea kumu. No laila, hāʻawi ʻia ka mea hana i ka hana hou e noiʻi ai i ka noiʻi nui, e hoʻoikaika i ka hoʻomohala aʻe o nā lāʻau lapaʻau. Huhi ia e hōʻemi i ke kumukūʻai o Ongliza ʻaʻole pono ia.

I loko o nā mākeke Lūkini, ma kahi o Onglisa, hiki iā ʻoe ke kūʻai i nā papa mai nā pūʻulu like o Galvus a me Januvius. ʻO kēia mau lāʻau like me nā hopena like me ka diabetes mellitus, kahi hoʻohālikelike i ka ʻōlelo palekana a me ka hana kūpono ʻaʻole i hōʻike i nā hōʻailona nui ma waena o lākou. Wahi a nā loiloi o ka maʻi maʻi, hiki iā ʻoe ke loaʻa iā lākou no ka manuahi ʻole ma nā wahi āpau, ʻoiai ke pili pū nei nā mea āpau i kēlā me kēia makahiki i ka papa inoa o nā lāʻau lapaʻau nui.

ʻO ke kūʻokoʻa kūʻokoʻa o kēia mau lāʻau e kūʻai i nā uku nui:

Hiki iā ʻoe ke kauoha i kēia mau pākīpeka i loko o nā lāʻau lapaʻau pūnaewele. I ka nui o lākou e loaʻa ai ka hopu pono ʻana i ka lāʻau lapaʻau mai nā lāʻau lapaʻau e kokoke ana i ka hale.

I ka makahiki 2017, ua hoʻolaha ʻia ke hoʻokuʻu ʻia o ka lāʻau hui pū me ka saxagliptin a me dapagliflozin i kapa ʻia ʻo Qtern. Hoʻopili pū ia i nā pono o kekahi o nā lāʻau lapaʻau maʻi kiʻekiʻe loa - Forsigi a me Onglisa. Ma Rusia, ʻaʻole i hoʻopaʻa inoa ʻia nā papa hou.

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