He aha nā antibodies insulin?

ʻO ke ʻano maʻi diabetes mellitus he maʻi maʻi ʻo ia o ka mea hana endocrine, e pili pū ana me ka luku ʻana i ka autoimmune o nā sela o nā mokupuni o Langerhans. Mālama lākou i ka insulin, a hōʻemi i ke kiʻekiʻe o ka glucose i ke kino.

ʻO nā hōʻailona o ke kūkuluʻana o nā antibodies i ka insulin e kū ana inā ʻoi aku paha ma kahi o ka 80% o nā pona e luku ʻia. ʻIke pinepine ʻia ka pathology i ke wā ʻōpio a i ʻole nā ​​ʻōpio. ʻO ka hiʻohiʻona nui ka hele i loko o ke kino o nā pūmua protein kūikawā o ka pulu koko, e hōʻike ana i ka hana autoimmune.

Hoʻoholo ka nui o ka mumū i ka helu a me ka ʻike ʻana o nā ʻano ʻano ʻokoʻa o ka ʻano lāʻau. ʻAʻole hiki iā lākou ke kaila wale nō, akā:

1. ʻO nā mokupuni o nā ʻāpana o ke kaomi o ka digestive e hana i nā hana i waho a me nā hana intracecretory;
2. ʻO ka lua e wehe i nā antigen o nā pona islet;
3. Glutamate decarboxylase.

Aia nā mea āpau ma nā papa G immunoglobulins o ʻāpana o ka hapa pākē o ke koko. Hoʻoholo ʻia ka ʻike a me ka nui o kona helu ʻana me ka ʻōnaehana hōʻike ma luna o ELISA. Hoʻohui ʻia nā hōʻailona koʻikoʻi o ka hoʻolālā mellitus maʻi maʻi me ka hana mua o ka hana ʻana i nā hoʻololi hoʻololi autoimmune. A ʻo kahi hopena, puka mai ka hana antibody.

Ke emi nei ka nui o nā sela ola, he nui ka nui o nā mea kanu i ka nui o ke ʻano o ka hoʻokahe koko e hōʻike nei iā lākou.

ʻĀpana Insulin Antibody

Nui nā mea makemake i: nā antibodies i ka insulin - he aha ia? ʻO kēia ʻano ʻano o ke molakē e hua ʻia e nā kime manu. Hoʻopiʻi ʻia i ka hana ʻana o kēkē iho. ʻO kēlā mau selela kekahi o nā kikoʻomanaʻo kikoʻī loa maʻamau no ka maʻi type 1. Pono kā lākou aʻo ʻana e hōʻike i ke ʻano o ke ʻano o ka maʻi insulin-depend-.

ʻO ka uptake glucose hoʻohaʻahaʻa ʻia ka hopena ma muli o ka hōʻeha ʻana o ka autoimmune i nā ʻāpana kūikawā o nā kelepona nui loa o ke kino kanaka. Ke alakaʻi ia nei i ka nalowale holoʻokoʻa o ka hormone mai ke kino.

K ua koho ʻia ʻo Antibodies i insulin e IAA. Hōʻike ʻia lākou i loko o kahi serum koko a ma mua o ka hoʻomakaʻana o kahi hormone o ka protein kumu. I kekahi manawa hoʻomaka lākou e hoʻopili ʻia 8 mau makahiki ma mua o ka hoʻomaka ʻana o nā hōʻailona o ka maʻi maʻi.

ʻO ka ʻike ʻia o kekahi mau o nā antibodies e hilinaʻi pololei i ka makahiki o ke kanaka maʻi. Ma 100% o nā hihia, ʻike ʻia nā pūmua protein inā loaʻa nā hōʻailona o ka maʻi diabetes ma mua o 3-5 mau makahiki o ke ola o ka pēpē. Ma 20% o nā hihia, ʻike ʻia kēia mau sela ma nā pākeke e maʻi ana i ka maʻi diabetes mika 1.

Ua hōʻike ʻia nā noiʻi o nā ʻepekema ʻē aʻe e ulu ka maʻi i loko o hoʻokahi makahiki a me ka hapa - ʻelua mau makahiki i ka 40% o nā kānaka me ke koko anticellular. No laila, he ala mua ia no ka nānā ʻana i ka hapa o ka insulin, ka hana hōʻoliʻeu o ka mea laʻa.

Pehea e pae ʻia ai nā antibodies.

ʻO ka insulin ka hormone kūikawā e hana ai i ka pancreas. Na ia e kuleana no ka hoʻemi ʻana i ka glucose i loko o ka nohona olakino. Hāpai ka hormone i nā selona endocrine kūikawā i kapa ʻia he mau moku ʻo Langerhans. Me nā hiʻohiʻona o ka maʻi diabetes mellitus o ke ʻano mua, ua hoʻohuli ʻia ka insulin i kahi antigen.

Ma lalo o ke ʻano o nā mea like, hiki ke hoʻolaʻa ʻia nā antibodies ma o lākou iho iho i ka insulin, a me kekahi o nā mea i hoʻopaʻa ʻia. ʻO nā mea hoʻomoʻi kūmole kūikawā i ka hihia mua e alakaʻi i ke ʻano o nā hopena alerine. Ke hana ʻia nā inikini, kūkulu ʻia ka pale kū ʻana o ka hormone.

Hoʻopili i nā antibodies i ka insulin, ua hoʻokumu ʻia kekahi mau antibodies i loko o nā mea maʻi me ka maʻi mellitus. ^ E Ha yM. ʻO ka maʻamau, i ka manawa o ka maʻi, ʻike paha ʻoe i ka:

• Loaʻa iā 70% o nā kumuhana he ʻekolu mau ʻano o nā antibodies;
• 10% o nā mea maʻi - ka mea nona nā ʻāpana hoʻokahi wale nō;
• ʻAʻohe o 2-4% o nā mea maʻi he mau kikoʻī kūikawā i loko o ka serum koko.

ʻOiai nō ke hōʻike mau nei nā antibodies i ka maʻi type o ka maʻi type 1, aia kekahi mau hihia i ka wā i ʻike ʻia ai lākou ma ka maʻi maʻamau ʻo type 2. ʻO ka maʻi mua ka mea i hoʻoili ʻia. ʻO ka hapa nui o nā poʻe maʻi nā mea lawe i nā ʻano like ʻole o HLA-DR4 a me HLA-DR3. Inā pili nā maʻi i ka pili o ka maʻi āpau me nā maʻi maʻi type 1, a laila e piʻi aʻe ana ka maʻi o ka maʻi e 15 mau manawa.

Nā hōʻailona no ka hoʻopaʻa ʻana ma nā antibodies

Lawe ʻia ke koko Venous no ka nānā ʻana. ʻImi ʻia kāna noiʻi no ka maʻi mua o ka maʻi maʻi. Ua kūpono ka loiloi:

1. No ka hana ʻana i ka hopena maʻi;
2. ʻO ka ʻike ʻana i nā hōʻailona o ka prediabetes;
3. ʻO ka wehewehe ʻana o ka predisposition a me ka loiloi hopena;
4. Hoʻopiʻi ka pono o ka insulin therapy.

Hoʻolaha ʻia ka haʻawina no nā keiki a me nā pākeke pili i nā hoahānau pili pili me kēia mau ala. He kūpono nō hoʻi i ka wā e nānā ana i nā kumuhana e loaʻa mai ana i ka maʻi hypoglycemia a i ʻole ʻaihue i ʻole ke ahonui glucose.

ʻO nā hiʻohiʻona o ka loiloi

Hoʻohui ʻia ke koko Venous i kahi pahu hōʻike hoʻāʻo me ka gel hoʻokaʻawale. Hoʻopili ʻia ka pūnaewele wina me ka pōkā pale e hoʻopau i ka kahe koko. ʻAʻole koi ʻia kahi hoʻomākaukau koʻikoʻi no ia noi ʻia, akā, e like me ka hapa nui o nā hoʻāʻo ʻana, ʻoi aku ka maikaʻi ke hāʻawi i ke koko i ke kakahiaka.

Nui nā manaʻo kikoʻī:

1. Mai ka ʻaina hope a i ka hāʻawi ʻana o biomaterial, aia i 8 mau hola e hala;
2. ʻO nā mea e inu ai i ka waiʻona, nā meaʻai momona a me nā palaoa i hōʻoki ʻia mai ka meaʻai i hoʻokahi lā;
3. Hiki paha i ke kauka ke hāʻawi i ka hoʻoikaika kino;
4. Mai ulaula i hoʻokahi hola ma mua o ka lawe ʻana i ka biomaterial;
5. He mea pono ʻole ia e lawe i ka biomaterial i ka wā e lawe ai i ka lāʻau lapaʻau a ma lalo o nā kaʻina physiotherapeutic.

Inā makemake ʻia ka ka nānā ʻana i nā māka i nā dinamics, a laila kēlā me kēia manawa ke hana ia ma nā kūlana like.

No ka hapa nui o nā mea maʻi, he mea nui ia: pono anei i kekahi ke ʻano o ka antibodies i ka wina. ʻO ka maʻamau ka pae inā kau lākou mai kā 0 a 10 mau papa / ml. Inā nui nā mea i koe, a laila hiki iā mākou ke manaʻo i ke kumu o ka maʻi mellitus type 1 wale nō, akā:

• ʻO nā maʻi e hōʻike ʻia e ka hopena o ka autoimmune mua i nā kihi endocrine;
• Autoimmune insulin syndrome;
• Allergy i huikia i ka insulin.

ʻO ka hopena maikaʻi aʻe e hōʻike pinepine i kahi kapu. Inā aia ma kahi mau maʻi maʻi maʻi maʻi, a laila hoʻouna ʻia ka mea maʻi no ka maʻi e ʻike i kahi maʻi metabolic, ka mea i hōʻike ʻia e ka maʻi hyperglycemia.

Nā hiʻohiʻona o nā hopena o kahi hōʻike koko no nā antibodies

Me ka nui o nā antibodies e hoʻonui i ka insulin, hiki iā mākou ke manaʻo i ka loaʻa o nā maʻi autoimmune ʻē aʻe: lupus erythematosus, nā maʻi ʻōnaehana endocrine. No laila, ma mua o ka hana ʻana i kahi maʻi a me ka kuhikuhi ʻana i kahi maʻi maʻi, ua hōʻiliʻili ke kauka i nā ʻike āpau e pili ana i nā maʻi a me ka hoʻoilina, a ke hana nei i nā ʻano diagnostic ʻē aʻe.

ʻO nā ʻōmaʻomaʻi kumu e lilo ai i ka kānalua o ka maʻi type 1 i komo ʻia:

1. Ka makewai ikaika;
2. ʻO ka hoʻonui aʻe o ka nui o ka urine;
3. ʻO ka lilo kaumaha
4. Hoʻonui i nā momona;
5. ʻO ka hoʻohaʻahaʻa i ke kōkē ʻike a me nā mea ʻē aʻe.

ʻ saylelo nā kauka e 8% o ka lahilahi olakino i loaʻa i nā antibodies. ʻO kahi hopena maikaʻi ʻaʻole kahi hōʻailona no ka nalowale o ka maʻi.

ʻAʻole loaʻa ia kahi hōʻike hoʻoliʻi hae a me ka hōʻike ʻana no ka maʻi pākēnē. Akā he kūpono ia ka nānā ʻana no nā keiki me ka luhi. I nā maʻi me ka hopena o ka hōʻike maikaʻi ʻana a me ka ʻole o ka maʻi, ʻo nā ʻohana pili he nui ka like me nā kumuhana ʻē aʻe i loko o ka lāhui like.

Hoʻokomo i nā mea hōʻike

ʻO ke ʻano o nā antibodies e hoʻohana i ka insulin e ʻike pinepine i nā pākeke.

I loko o nā mahina 6 mau mua ma hope o ka hoʻomaka ʻana o ka maʻi, hiki ke hoʻēmi i ke ʻano o nā antibodies i kēlā mau pae i hiki ʻole ke hoʻoholo i ko lākou helu.

ʻAʻole hiki i ka loiloi ke wehe ʻana, ua hana ʻia nā pūmua protein i kā lākou iho ponoʻī a i ʻole exogenous (lawelawe ʻia ma o kahi inikini). Ma muli o ke kūlana kiʻekiʻe o ka hōʻike, ke kauka nei ke kauka i nā hana diagnostic hou e hōʻoia ai i ka maʻi maʻi.

Ke hana nei i kahi hōʻike maʻi, i manaʻo ʻia nā mea penei:

1. Hoʻomaka ka maʻi Endocrine e kahi hopena autoimmune e kū'ē ana i nā sela o kāu pancreas.
2. ʻO ka hana o ke kaʻina hana e hilinaʻi pololei i ka neʻe ʻana o nā antibodies i hua ʻia.
3. Ma muli o ka hoʻomaka ʻana o nā protein hou loa ma mua o ka puka ʻana o ke kiʻi lapaʻau, aia nā mākaukau mua no ka maʻi maʻi mua o ka maʻi maʻamau.
4. Ua lawe ʻia ia i loko o ka pākeke a me nā kamaliʻi, nā ʻāpana like ʻole e kū'ē i ka wā o ke ahulau.
5. ʻO nā antibibies i ka hormone he nui aku ka waiwai diagnostic i ka wā e hana nei me nā poʻe maʻi o ka ʻōpio a me ka makahiki waena.

ʻO ka mālama ʻana i nā mea maʻi me ka maʻi diabetes mellitus type 1 me nā antibodies i ka insulin

ʻO ke pae o nā antibodies i ka insulin i ke koko he mea koʻikoʻi diagnostic koʻikoʻi. ʻAe ia i ke kauka e hoʻoponopono i ka maʻi maʻi, e pani i ka hoʻomohala ʻana i ka pale i kekahi mea e kōkua ai e hoʻoponopono i nā pae glucose koko i nā pae maʻamau. Hōʻike ka pale me ka hoʻomaka ʻana o nā hoʻomaʻemaʻe hoʻomaʻemaʻe maikaʻi ʻana, ma laila aia kekahi proinsulin, glucagon a me nā ʻāpana ʻē aʻe.

A inā pono, ua hoʻomaʻemaʻe ʻia nā puka hoʻomaʻemaʻe maikaʻi (maʻa mau i ka puaʻa). ʻAʻole lākou e alakaʻi i ka hoʻokumu ʻana o nā antibodies.
I kekahi manawa ʻike ʻia nā antibodies i ke koko o nā poʻe maʻi e mālama ʻia ana me nā lāʻau hypoglycemic.