I ka wā o ka ʻenehana ʻikepili a me nā hanauna hou o ka lāʻau antidiabetic, e hoʻomau ʻia ka lāʻau lapaʻau hoʻokoe lāʻau manawa. ʻO ka mea kaulana loa, ʻo ia ka mea e hoʻoulu ai i ka pancreas e hana hou i ka insulin. Ke kamaʻilio nei mākou e pili ana i nā kiʻi o nā pūʻulu sulfonylurea a me nā halepuleʻelima nesulfanylurea - nā palapala lepo.
Noho ʻo Repaglinide i nā hui hope loa. ʻO kona ʻokoʻa nui ka hopena ma ka hoʻomaka mua o ka hoʻokuʻu ʻana o ka hormone i loko o ke kahe wai, i ka wā o hope o ka ʻaʻai i ke koko aia ke ʻano nui i loko o nā pae glucose, a me ke kino o ka maʻi maʻi maʻi (me nā maʻi like 2) ʻaʻole hiki ke hoʻokō ʻia.
Ma hope o ka heluhelu ʻana i nā ʻōkuhi, ke kaupaona nei i nā mea hoʻopiʻi a me nā mea ʻē aʻe, hiki iā ʻoe ke kūkākūkā me kāu kauka i ka regimen mālama maʻi maʻi.
Hoʻohui a me ka wehewehe ʻana o ka lāʻau lapaʻau
Aia i kēlā me kēia papa āpau he 0.5 a 1 mg paha o ka hana ikaika o ka micagized repaglinide, hoʻohui ʻia me nā mea kōkua: calcium hydrogen phosphate anhydrous, colloidal silicon dioxide, microcrystalline cellulose, sodium croscarmellose, hydroxypropyl cellulose, meglumine, magnesium stearate, dyes.
Hiki ke ʻike ʻia nā ʻāpana biconvex i ka kahakaha ʻana me nā helu e hōʻike ana i ka nui. Me kahi hōʻailona o 0,5, ke keʻokeʻo nei lākou, me 1 mg - lavender a melemele paha. Ma ke kua ke ike oe i ka olelo hooponopono o ka RP, J a me na mea e ae. Hoʻopili ʻia nā papa he 10 i nā palaka. Nui nā papa like i loko o ka pahu pepa.
Loaʻa ka lāʻau lapaʻau papaʻa. ^ E Ha yM. He kumukūʻai kūpono ke kumukūʻai no Repaglinide: 30 mau papa o 2 mg ma Moscow e hiki ke kūʻai no ka 200-220 rubles. Hoʻokuʻu lākou i nā lāʻau lapaʻau ma Tenemaka, Israel, India a me nā ʻāina ʻē aʻe, e komo pū ana ma ka ʻāina post-Soviet.
ʻO ka noho papa ola o ka lāʻau lapaʻau, i hoʻolaha ʻia e ka mea hana, ma ke ʻano he 3 mau makahiki. ʻAʻole pono ka lāʻau lapaʻau i nā kūlana kūikawā no ka mālama. Ma hope o ka manawa kikoʻī, pono e hoʻokuʻu ʻia nā papa.
Nā hiʻohiʻona Pharmacological
ʻO ka hopena nui o ka lāʻau lapaʻau ka hypoglycemic. Hoʻopilikia ke kaukaʻi i nā hāmeʻa pālala hilinaʻi ATP i loaʻa i ka membrane b-cell, ka mea i hāʻawi i ko lākou depolarization a me ka hoʻokuʻu i nā kanikani calcium. No laila, ʻo ka mea hoʻopunipuni e hoʻohālikelike i ka uptake hormone.
ʻAʻole i ʻike ʻia nā haʻawina hauoliola mutagenic, teratogenic, carcinogenic effects i nā holoholona a me ka ulu ʻana o kahi maʻi.
Hoʻokomo ʻia ʻo Repaglinide me ka wikiwiki mai ka hapa o ke kaomi ʻana, hiki i kona nui o ke koko i ka hola.
Inā lawe ʻia me ka ʻai, ua hoʻemi ʻia ʻo Cmax ma ka 20%. Holo wikiwiki ka ʻai ʻana o ka lāʻau a hiki i ka hiki ʻana o nā hola 4 ma kahi liʻiliʻi loa. Hoʻopaʻa ka lāʻau i nā protein plasma i aneane holoʻokoʻa (mai 98%) me ka bioavailability o 56%. ʻO Biotransformation me ka hoʻokumuʻana o nā metabolites inert e pili ana i ka mokiki.
Hoʻopauʻia ka lāʻau lapaʻau i nā hola 4-6 me kahi hapalua ola o ka hola 1. Ma 90% ka mea e maalo aku i nā dile bile, ma kahi o 8% e hoʻopau ʻia e nā keiki.
ʻO wai ka mea ʻo Repaglinide i manaʻo ʻia no kēlā?
Hoʻolālā ʻia ka lāʻau lapaʻau e mālama i ka maʻi type 2 no ka mea ʻo ka loli o ke ola (haʻahaʻa-pahu liʻiliʻi, lawa ʻana i nā ʻōpū ikaika, ʻona o ka naʻau mana) ʻaʻole e hāʻawi i ka mana glycemic piha.
Hiki ke hoʻohana i ka glinide i ka mālama paʻakikī i ka metformin a me ka thiazolidinediones, inā he monotherapy, nā therapeutic meaʻai a me ka hana kino ʻaʻole i hāʻawi i ka hopena i makemake ʻia.
Ka mea nona a Repaglinide
Hoʻopili i nā mea kuʻuna kuʻuna (ka intolerance pilikino, ka hapai, nā keiki, ka hōʻoki o ka waiū), ua hoʻohui ʻia ka lāʻau lapaʻau.
- Maʻa maʻi maʻi me nā maʻi ʻano ʻehā;
- Me ka ketoacidosis maʻi maʻi;
- I loko o ka'āina o ka coma a me ka precoma;
- Inā nui ka maʻi ma ka palaka a me nā ʻāpana o ke ake;
- I nā kūlana e koi ana i kahi hoʻololi manawa pōkole i ka insulin (maʻi, trauma, ʻoki).
Pono e mālama pono i ka hāʻawi ʻana i nā glinides i ka waiʻona, ka poʻe me ka maʻi maʻi o ka maʻi, a me ke kuni.. ^ E Ha yM. Aia nā palena o nā makahiki: mai kau i nā lāʻau lapaʻau i ka maʻi maʻi ma mua o 18 a ma hope iho o 75 makahiki ma muli o ka nele o ka hōʻike no kēia mau māhele.
Ke ʻano o ka noi
No ka repaglinnid, nā ʻōlelo e pili ana i ka hoʻohana ʻana e lawe i ka paʻu preprandially (ma mua o ka papaʻaina). E koho ke kauka i ka ʻikepili e pono ai no ka mālama glycemic optimal e like me nā hopena o nā loiloi, kahiʻano o ka maʻi, nā ala e hoʻohālikelike ai, ʻoi aku, ka makahiki kūʻokoʻa o ke kino o kēlā me kēia pālolo.
No ka wehewehe ʻana i ka laiki therapeutic liʻiliʻi, pono e kāohi i ka ʻai o ka pōloli a postprandial ʻelua ma ka home a ma ka pūnaehana. Ke hoʻoponopono nei i nā paʻi o ka lāʻau lapaʻau, ke alakaʻi pū nei lākou i nā hōʻailona o nā hemoglobin glycated.
Pono ke kiaʻi pono ʻana e ʻike i ka hemahema mua a me ka lua, inā hāʻule ka pae glycemia ma lalo o kahi maʻamau ma ka hoʻomaka ʻana o ke papa a ma hope paha o ka manawa mua o ka hopena.
ʻAʻole koʻikoʻi ka manawa no ka lawe ʻana i ka repaglinide: 15-30 mau minuke ma mua o kahi pāʻina a i ʻole hoʻomaka i kahi pāʻina. Inā hoʻohui ʻia kekahi snack (a i ʻole mokipī), a laila i hoʻohui ʻia kahi kīwaha (a i ʻole ʻū ʻia).
Inā ʻaʻole i loaʻa ka mea maʻi i nā lāʻau lapaʻau hoʻokaʻa koko, pono e liʻiliʻi iki ka nui o ka pālolo - 0,5 mg ma mua o kēlā me kēia pāʻina. Inā hoʻohuli ʻo ia i repaglinide me kahi lāʻau lapaʻau antidiabetic hou, hiki iā ʻoe ke hoʻomaka me 1 mg ma mua o kēlā me kēia pāʻina.
Me ka mālama mālama ʻana, ʻaʻole iʻoi aku ka nui ma mua o 4 mg ma mua o ka papa nui. ʻO ka huina o ka pālolo pākina i kēlā me kēia lā ʻaʻole pono e hoʻonui i ka 16 mg.
Me ka hoʻomaʻamaʻa paʻakikī, ʻaʻole e loli ka hapa o ka repaglinide, a ua koho ʻia nā ʻano o nā lāʻau lapaʻau e like me nā heluhelu ʻana o ka glucometer a me nā regimens therapeutic ma mua.
Nā hopena hopena
ʻO ka hopena koʻikoʻi ʻoi loa ka hopena o nā glinids, hypoglycemia koʻikoʻi nui. I ke koho ʻana i ka lāʻau lapaʻau, pono ke kauka e hōʻike i nā maʻi i kona mau hōʻailona a me nā ala o ke kōkua mua a me ka mālama pono ʻana no ka mea i make.
Ma waena o nā hanana ʻē aʻe ʻole:
- Nā maʻi Dyspeptic;
- Hoʻowahāwahā i ke kaniʻana o nā neʻe i loko o ke alo;
- Allhesic skinheshes;
- Hoʻohana ʻo ia o ka ate i ke ʻano o ka hoʻonui ʻana o transistor i ka hana o transaminases;
- Hōʻalo ka ʻike ma muli o nā ʻokoʻa o ka glycemic level.
Nā hopena hoʻopuka lāʻau lapaʻau
Me ka hoʻohana pākuʻi like me ka repaglinide me β-blockers, ACE inhibitors, chloramphenicol, inu ʻalowa, MAO inhibitors, indirect anticoagulants of NSAIDs, probenecid, salicylates, sulfonamides, anabolic steroid, the effective of clay pata.
ʻO ka hoʻokolohua i ka wā o ka repaglinide a me nā hāmeʻa blockers kalima, corticosteroids, thiazide diuretics, isoniazid, nicotinic acid ma ke ʻano kīkē lae ʻole, estrogen (i loko o nā contraceptives), sympathomimetics, phenothiazines, phenytoin, hoʻōla a me ka hoʻōla o nā thyroid.
Kōkua me ka overdose
Hiki ke ʻike ʻia kēia ʻano e:
- ʻO ka makemake ʻole;
- Kauʻeha;
- Hoʻolaha kiʻekiʻe;
- Hoʻonui i nā hopohopo;
- ʻO nā maʻi hiamoe;
- Ka hoʻololi i ke ʻano o ka hana kūpono (kahi ʻano e like me ka hoʻoinu ʻona ʻawaʻawa);
- Hōʻino ka ʻike a me ka ʻike ʻole;
- ʻAno o ka hoʻonohonoho ʻana a me ka nānā ʻana;
- E ʻike maopopo;
- ʻAla kino;
- Tachycardia;
- Pāwīwī puna;
- Kau kaho euhu;
- Nahea, coma.
He kōkua a kōkua ke kōkua aku i ka mea i make. Inā ʻike ka mea maʻi maʻi, pono e hāʻawi iā ia i nā kaikika wikiwiki (gula, kēkē) ma hope o kekahi manawa, e hoʻihoʻi hou i ka saturation o ke kino me ka glucose, no ka mea aia ke ʻano o ka hou ʻana.
Inā ʻaʻohe mea ʻike o ka mea maʻi i ka ʻike, e hoʻōla ʻia kahi hopena glucose (50%), e mālama i kahi kiʻekiʻe glycemic ma luna o 5.5 mmol / l, ua hoʻopiʻi kahi dropper me 10% hopena glucose. I nā pilikia koʻikoʻi, pono ke hoʻokipa i ka hoʻokipa.
Nā ʻōlelo ʻokoʻa
ʻO ka nānā nui (ka mālama ʻana i ka hoʻokē ʻai a me ke kōpaʻa postprandial, ka hana o nā huina target) ke koho ʻana i ka pālolo e koi ʻia e ka poʻe maʻi maʻi me nā pathal a me ka hepatic. Pono lākou e ʻike inā he ʻaeʻe i ka hoʻoneʻe a me ka regimen o ka lāʻau lapaʻau, ka hoʻohana ʻana i ka wai ʻona, kahi meaʻai haʻahaʻa, hoʻohaʻawa i ka naʻau, hoʻoulu ʻia ke kaumaha, pono ia e hoʻoponopono i ka ʻai ʻana o ka repaglinide, no ka mea hiki i nā ʻano ke hoʻohiki i ka hypoglycemia.
I ka pilina me nā hopena koʻikoʻi, pono e hoʻomaʻamaʻa ka mālama ʻana i ka wā e lawe ana i nā kaʻa a me nā mea paʻakikī, nā mīkini weliweli, i ka wā e hana ai ma nā wahi kiʻekiʻe, etc.
I mea e pale ai i ka hypoglycemia, nā maʻi maʻi me nā nāwaliwali nā nāwaliwali o ka poʻe mua, ʻo ia hoʻi ka poʻe i loaʻa i kēlā mau maʻi he mea maʻamau loa ʻole, pono ʻoe e lawe i nā hoʻomaʻemaʻe ʻē aʻe, e nānā ana i ka hopena o ka hopena a me kona hiki ke loaʻa.
Hoʻokomo hou - ʻaihue
Hoʻokuʻu ʻia ʻo Repaglinide ma lalo o nā inoa kālepa like ʻole: NovoNorm, Diclinid, Iglinid, Repodiab.
Wahi a ka code ATX o ka pae 4, ʻo nā ʻāpana antidiabetic ma Bayeta injections me ka hāpana kaha exenatide a me Viktoza me ka hāmeʻa ikaika liraglitide paʻa pū me ia.
Hoʻomaʻapaʻa kekahi mau maʻi maʻi i ko lākou maʻi i kahi ʻano kuhihewa ʻole, ʻaʻole maopopo ʻole i kēia maʻi luhi hiki ʻole ke hoʻouna i ka honua ʻē aʻe i kēlā me kēia manawa.
ʻO Repaglinide kahi mea maʻi hypoglycemic koʻikoʻi, hoʻokau pū me ka hoʻohālike ʻana pono a me ka hoʻololi ʻana i ka pōmaikaʻi i ke olakino, ʻoiai ka wikiwiki ka hana a ka lāʻau, me ka papa inoa koʻikoʻi o nā contraindications a me nā hopena hopena. Inā ʻoe e hōʻike iā ʻoe ma ka maʻi mellitus, pono ʻoe e mālama ʻia, me ka ʻole o ka waiho ʻana a hiki i hope.
Ma nā koho olakino no ka mālama ʻia ʻana o ka maʻi maʻi type 2 hiki ke loaʻa ma ka wikiō.
