AMARIL: NĀ LOILOI E LAWE NEI I KA LĀʻAU LAPAʻAU, NĀ HOPENA ʻAOʻAO A ME NĀ KUHIKUHI

Send

Nui ka poʻe i ka maʻi diabetes. Eia kekahi, i kēlā me kēia makahiki e ulu ana ka nui o nā poʻe e loaʻa nei i kēia maʻi.

ʻAʻole hiki ke hoʻōla i kēlā maʻi, akā naʻe, hiki ke mālama ʻia a mālama i ke ʻano maʻamau o ke kino.

I kēia hopena, e hoʻopuka i nā ʻano lāʻau like ʻole, ʻo ia ʻo ʻArearylary. Hōʻike pinepine ka ʻikepili i ka lāʻau lapaʻau. ʻO ka mea nui, ʻo ia ka nānā ʻana i nā hewa a me nā manawa hoʻokele. E heluhelu hou e pili ana i ka lāʻau lapaʻau ma kēia ʻatikala.

Ka hana lāʻau lapaʻau

ʻO ka hoʻomākaukau ʻana o ka pūʻulu sulfonylurea e pili ana i nā huila hypoglycemic no ka hoʻohana waha. Ma ke kāohi ʻana i ka pāo cytoplasmic potassium ATP-hilinaʻi i nā kaola o nā sel beta i loaʻa i ka pancreas, hoʻoulu ʻia ka hūnā.

I ka hopena, ua hoʻokuʻu ʻia ka insulin mai nā beta beta, e hōʻike ana i ka hopena pancreatic. Kānā ʻia kekahi hopena extrapancreatic ma muli, no ka mea i hoʻonui ʻia ai ka hana o ka insulin.

Amaril

Hiki i ka mea ikaika o ka lāʻau ke hiki ke hoʻohui pū i ka protein beta-cell. ʻO kona kaumaha molihope he 65 kD / SURX. Aia ka exocytosis o ka insulin. He mea nui ia ka hoʻonaʻau a ka hormone a me kāna hopena pono ʻole ke kī i ka hōʻemi o ka hōʻemi o ka hypoglycemia.

Loaʻa iā Amaryl kahi hopena antioxidant, antiplatelet, anti-atherogenic hopena. Hoʻonui loa kona hopena i ka ʻōnaehana cardiovascular, hoʻemi i ka pale ʻana i ka insulin. Hoʻonui ka hoʻohana ʻana o ka glucose i ka mololi a me nā ʻiʻo adipose ma muli o ka loaʻa ʻana o nā protein o ke kaʻa.
Ma ka hoʻonui ʻana i kā lākou hana, kōkua ke kōkua i ka uptake glucose maikaʻi aʻe. Hoʻopili ʻia nā lipogenesis a me glycogenesis.

Hoʻopili ʻia ka hoʻokumu ʻana o ka glucose hepatic, ma muli o ia ka nui o ka fructose-2,6-bisphosphate i ka hepatocytes i hoʻonui.

ʻO ka hūnā ʻia o ka COX i ka wā o ke alakaʻi ʻana o ka lāʻau lapaʻau e pale ʻia, ka waika arachidonic e hōʻemi ana i ka hoʻololi. Mālama kēia i ka hoʻēmi ʻana i ka platelet aggregation, i.e. aia kahi hopena antithrombotic.

Hoʻonui ka Alpha-tocopherol i ka wā i hoʻolaha ʻia i ka lāʻau. Eia kekahi, ʻo ka hana o ka diseroxide dismutase, catalase, glutathione peroxidase e hoʻonui ʻia, a me ka hopena o ka oxidative e kū mai ana i ka maʻi mellitus maʻi.

Nā hōʻailona no ka hoʻohana ʻana

Hoʻolālā kū ʻia ʻo Amaryl no ka hoʻohana ʻana ma ka lāʻau diabetes type 2. Hoʻohana ia e like me monotherapy, a no ka mālama hui ʻana. ʻO ka lāʻau Amaril no ka maʻi maʻi maʻi diabetes 2 he mau loiloi maikaʻi i ka wā i lawe ʻia me ka metformin a i ʻole insulin.

ʻO ka hoʻonohonohoʻana o ka lāʻau, hoʻokuʻu puka

Hoʻohana ʻia ka Amaryl i ke ʻano o nā papa, i hiki ke loaʻa i nā ʻokoʻa ʻē aʻe, ʻo ia ka 1, 2, 3, 4 mg.

ʻO ka mea hoʻonaninani ma kēia mea he glimepiride, a me nā mea kōkua no ka molohala lactose, magnesium stearate, microcrystalline cellulose, dyes E132 a me E172, povidone.

ʻO kēlā me kēia papa pākuʻi he laina hoʻokaʻawale, me ke kahakaha hoʻi. Aia i ka lōʻau ia i nā blisters ʻelua aia i nā papa 15.

E maʻalahi nā mea e hoʻokaʻawale i nā papa me nā ʻokoʻa ʻē aʻe ma muli o ko lākou mau kala ʻokoʻa. Nā papaʻuʻina me nā mea e hoʻonaninani ai i ka memo ma 1 mg pink, 2 mg green, 3 mg yellow, 4 mg blue.

Nā Hoʻohui

ʻAʻole e lawe ʻia ʻo Amaril i kēia mau hihia:

lactation a me kahi hāpai;
maʻi mellitus type 1;
ka ahonui i kēlā me kēia mea;
makahiki o na keiki;
diabetes ketoacidosis;
nā maʻi a me nā maʻi;
ka nele o ka lactose, maʻi malabsorption glucose-galactose.

He mea nui loa ia e mālama me ka akahele ma ka pule mua. He mea kūpono ia ke nānā ʻana i ke ʻano o ke kino e hōʻemi i ka hopena o nā hopena ʻaoʻao, e komo pū ana me ka hypoglycemia.

Nā hopena hopena

Me ka hoʻohana pono ʻana o ka lāʻau lapaʻau, hiki ke ʻike ʻia nā hopena he nui:

nā hana hoʻoweliweli o ka ʻōnaehana hoʻonāukiuki: nīwele, nā hemahema, nāwaliwali, nā luhi, nāʻauʻau, nā ʻōpū, ka paresis, nā lūlū, ka aphasia, ka hopohopo, ke nānā aku a ka lohe, ka luhi, ka hopohopo hiamoe, ka ʻeha, ka hopohopo o ka pale ʻana, ka hoʻopaʻapaʻa;
ʻōnaehana cardiovascular - tachycardia, angina pectoris, hypertension arterial, bradycardia, ʻehaʻeha o ka naʻau;
maʻi hōʻiliʻili maʻi - ka ʻike ʻana i nā hopena o ka hypoglycemic;
gastrointestinal tract - ka ʻeha o ka ʻōpū, ka luaʻi, ka maʻi āpau, ke nānā ʻana i ka maʻi o ka naʻau, hepatitis, cholestasis;
ʻōnaehana helehelena - thrombocytopenia, granulocytopenia, agranulocytosis, erythrocytopenia, hemolytic a aplastic anemia;
nā hopena ʻē aʻe ka nānā ʻana i ka ʻike a me ka hanu papau, hypersensitivity ma ke ʻano o ka heching, kapa nunui, urticaria, vasculitis allergic.

Nā ʻōkuhi no ka hoʻohana

Pono ʻoe e lawe i kahi kīʻaha ma loko me ke kua ʻole o ka moʻo. Pono ka wai ʻona ma kahi o ka hapa aniani o ka wai.

Pono e lawe i ka lāʻau lapaʻau e hoʻopili ʻia i ka ʻai, inā ʻaʻole hoʻoweliweli ʻia me ka hoʻokaʻawale o ke kōhi koko.

ʻO ke kumu kēia e pono ʻoe e inu i ka pōpoki ma mua o ka papaʻaina a i kēia wā o kēia kaʻina. Hoʻohana maikaʻi ʻia kēia ma ke kakahiaka, inā hoʻokahi ka noi i hoʻokahi i kēlā me kēia lā, i hiki ai iā ʻoe ke hohi i ke kō.

ʻO ka hopena mua o ka lāʻau lapaʻau he 1 mg o ka mea i ka lā. ʻOi aku, inā pono, hiki nō ke hoʻonui i ka hewa ma ka palena o 1-2 mau pule. I kēia hihia, ʻo ka hopena hou aʻe he 2 mg, a laila 3 mg, a laila 4 mg, a laila hiki ke hoʻohana ʻia 6 mg. ʻO ka nui o kēia dosage ka mea hiki, ʻaʻole ia e hāʻawi ʻia ma mua.

Pono ka hoʻonui ʻana i nā ʻauamo, e lawe ʻia e ke kauka, e pili ana i nā hiʻohiʻona pilikino, ke ʻano o ka mea maʻi, ke ʻano o ka maʻi.

Hiki ke lawe ʻia ʻo Amaril i loko o ka hui pū ʻana me ka insulin a me ka metformin. I nā hihia a lawe ʻole mai ka Metformin i ka emi o ke kō, ua hoʻohālikelike ʻia ʻo Amaril.

I kēia kūlana, hoʻomau ʻo Metformin e lawe i ka make ma mua, a hoʻomaka ʻana ʻo Amaryl e inu me ka wai liʻiliʻi o 1 mg, hiki iā ia ke hoʻonui iki i 6 mg. Inā hoʻomaʻamaʻa ʻole kēia hui ʻana, a laila hoʻololi ʻia ka Metformin e ka insulin. Ma kēia hihia, ke waiho nei ka nui o ke ʻano o Amaril, a lawe ʻia ka insulin ma ka liʻiliʻi e ʻae ʻia, e hoʻonui me ka dosis.

Ke lawe nei i nā lāʻau lapaʻau, ʻoiai me ka hui pū ʻana o Amaryl-insulin, pono ia e hōʻoia pinepine i ka pae o ke kō. Pono e hoʻomanaʻo ʻia i ka wā e hoʻohana ai iā Amaril, pono ʻia ka nui o ka insulin 40% ma mua o ka hihia o ka monotherapy.

Ke keu

Inā hoʻonui ʻia ka nui o ka lāʻau, a ua hoʻoweliweli ka mea maʻi i ka hypoglycemia, kū i ka mau hola 12-72.

ʻO nā ʻololino e like me nā hopena pili o ka lāʻau i haʻi ʻia ma ka ʻatikala. I nā hihia koʻikoʻi, kiʻekiʻe ka hopena o ka hoʻolālāʻana i kahi coma.

Inā hele mai nā ʻōmaʻomaʻi mua, ʻo ka mea mua e pono ai ʻoe e ʻai i kahi ʻāpana o ke kō, inu inu wai a kīwī paha. Pono mau e mālama i ka liʻiliʻi o 20 g o ka glucose me ʻoe, no ka laʻana, hiki iā ia ke 4 ʻāpana o ke kō. ʻO nā mea aloha i kēia hihia e lawe i kahi hoʻohana liʻiliʻi.

Inā he hihia ka hihia, a laila e koi ʻia ka hoʻokipa. I ka haukapila, hana ʻia ka lavage gastric, a pono ʻia hoʻi nā adsorbents. He mea koʻikoʻi ke kuleana Glucose. Hoʻokuʻu ʻia nā hōʻailona ʻē aʻe maikaʻi e ke ʻano maʻi.

Hoʻohui nūhou

Me nā lāʻau'ē aʻe, hiki i ka hoʻohanaʻana iā Amaril ke piʻi i lalo a hōʻemi paha i ka hopena hypoglycemic.

I ka hihia mua, e emi iho ka hopena ma hope o ka lawe ʻana i nā lāʻau lapaʻau e pili ana: nā hormones thyroid, adrenaline, chlorpromazine, sympathomimetics, glucocorticosteroids, diazoxide, barbiturates, laxatives, saluretics, thiazide diuretics, glucagon, phenytoin, phenothiazine, acetazolamide, nui nui , nā progestogens a me nā estrogens, nā paʻakai lithium.

Ka hoʻonui ʻia ʻana o ka hopena hypoglycemic ke nānā aku i ka wā e lawe ai i nā lāʻau lapaʻau me ʻAmaril: nā lāʻau lapaʻau ʻē aʻe no ka mālama ʻana i ka hypoglycemia, angiotensin-converting factor inhibitors, allopurinol, anabolic steroids, Coumarin derivatives, tritokvalin, nā lāʻau lapaʻau me nā kāne sex hormones, oxyphenbutazone, pentoxifylline, hloramphenolone phenolic , nā fibrates, feniramidol, MAO nā mea pale, azapropazone, fenfluramine, probenecid, salicylates, sulfinpyrazone, tetracyclines, tro-, cyclo-, isophosphamide, sulfonyls hana lōʻihi dy.

ʻO ka hui pūʻana o Amaril me kekahi mau lāʻau lapaʻau hiki ke alakaʻi i kahi hopena hypoglycemic hiki ʻole, e hiki ke emi i loko o kekahi mau kūlana, a ma nā mea ʻē aʻe e hoʻonui. Aia kēia mau Reserpine, Clonidine.

Nā hōʻikeʻike e pili ana i ka lāʻau lapaʻau Amaryl

E pili ana i ka lāʻau lapaʻau Amaril, maikaʻi loa nā loiloi o nā maʻi maʻi maʻi. ʻO nā mea maʻi e lawe nei iā Amaryl e manaʻo maikaʻi nei kēia lāʻau lapaʻau i nā hē kiʻekiʻe ma nā maʻi diabetes type 2.

ʻO ka mea nui ke koho i ke ʻano kūpono o nā lāʻau lapaʻau. ʻO ka ʻaoʻao kūpono ka ʻokoʻa o nā ʻāpana like ʻole o nā papa, i hoʻopili ʻia me nā ʻano like ʻole. ʻAe kēia iā ʻoe e hoʻokūkū i ka mea kūpono.

Eia nō naʻe, nui nā loiloi maikaʻi, pili pū me ka pinepine o nā hopena o nā hopena ʻokoʻa, e like me nā haʻalulu, nāwaliwali, nā helehelena, nā wīwī i loko o ke kino, hoʻonui nui ʻia. Aia kekahi mau hihia o ka hypoglycemia, no laila he mea nui loa e halihali i nā lepe a i ʻole nā huahana ʻē aʻe kahi o ke kō.

Hiki ke lohe ʻia nā loiloi maikaʻi mai nā mea hoʻokele e lawe ana iā Amaryl. Hoʻokomo ka lāʻau lapaʻau i ka ʻōnaehana o ka pīpī, no laila ke hoʻemi ʻia ka hopena, he pōʻino loa i ka wā e holo ana. Eia kekahi, ʻoiai ke kūpono o ka lāʻau lapaʻau, ʻoi aku ka nui o kona kumukūʻai ma mua o nā analogues.