ʻO Biguanides i ka mālama ʻana i ka maʻi maʻi

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ʻO ka mea i hala koke nei, ua hoʻohana nui ʻia nā māpia hypoglycemic e pili ana i ka metformin (Buformin, Metformin, Fenformin, etc.) no ka mālama maʻi ʻana. Loaʻa kā lākou hoʻohana ʻana i nā pono kūpono. E noʻonoʻo i nā hiʻohiʻona o kēia mau pūhui, kā lākou hopena a me nā ʻano o ka mālama ʻana i ka maʻi diabetes me kā lākou kōkua.

Pehea lākou e hana ai

Ua hoʻohana ʻia ʻo Biguanides no ka maʻi maʻi mai ka makahiki 1970. ʻAʻole lākou e hana i ka hilahila insulin e ka pancreas. ʻO ka hopena o ia mau lāʻau ma muli o ke kaohi ʻana o ke kaʻina gluconeogenesis. ʻO ka mea maʻamau ka maʻi maʻamau o kēia ʻano ʻo Metformin (Siofor).

ʻAʻole e like me sulfonylurea a me nā mea nona nā kumu o ke kumu ʻo Metformin, ʻaʻole ia i hoʻohaʻahaʻa i ka glucose a ʻaʻole i hoʻoulu i ka hypoglycemia. He mea koʻikoʻi kēia ma hope o ka wikiwiki wikiwiki. Hoʻopā ka lāʻau lapaʻa i ka hoʻonui o ke kōhi koko ma hope o ka ʻai ʻana Hoʻonui ka Metformin i ka ʻike ʻana i nā pūpū a me nā ʻili o ke kino i ka insulin. Eia kekahi, hoʻomaikaʻi ia i ke kahe o ka glucose i loko o nā ʻili a me nā kiko, e hoʻolōʻihi i kona ʻili i loko o ka wahī.


ʻO Metformin ka mākaʻi nui o nā pūʻulu biguanide o nā lāʻau lapaʻau

Me ka hoʻohana mau ʻana, loaʻa nā hopena biguanides i ka momona metabolism. Ke hoʻolōʻihi nei lākou i ke kaʻina o ka hoʻololi i ka glucose i nā momona momona, a ma kekahi mau mea e hōʻemi ai i nā mea o nā triglycerides, cholesterol i loko o ke koko. ʻAʻole ʻike ʻia ka hopena o nā biguanides i ka haʻalele ʻana o ka insulin.

Hoʻokuʻu maikaʻi ʻia ka Metformin mai ka gastrointestinal tract a komo i loko o ke koko koko, kahi e loaʻa ai kona kiʻekiʻe kiʻekiʻe i ʻelua mau hola ma hope o ka hoʻokele ʻana. ʻO ka hoʻopau hapa-hapalua ke ola a hiki i ka 4,5 hola.

Nā hōʻailona a me nā contraindications

ʻO ka hōʻailona nui no ka mālama ʻana me kēia mau lāʻau nā non-insulin-dependence mellitus. Pono lākou i nā hihia a hui pū ʻia ka maʻi maʻi me ka momona. Akā ʻo ka hapa nui o nā maʻi me ka maʻi maʻi e loaʻa pū nō hoʻi i ke kaumaha nui o ke kino, ka mea e hoʻopau i ka papa o ka maʻi.

Malia paha e hoʻohana i nā biguanides i hui pū me ka insulin. Hiki iā ʻoe ke hana iā lākou i hui pū me nā lāʻau lapaʻau haʻahaʻa.


Hoʻomaopopo nui ka Metformin no nā maʻi me ka maʻi maʻi a me ka momona hiʻona.

Hoʻokomo ʻia ka lāʻau i ia mau hihia:

  • diakene-hilinaʻi i ka insulin (koe wale ke hui pū me ka obesity);
  • ka pau ʻana o ka hana insulin;
  • ketoacidosis;
  • pilikia ʻole ʻole, hana i ʻole ke aho;
  • cardiovascular a me kahi hanu hana;
  • louʻai, pīhoihoi;
  • lāleʻa hemahema;
  • lactic acidosis;
  • hanau, hanau mai;
  • nā haʻahaʻa-kaloli liʻiliʻi (liʻiliʻi i lalo o 1000 kilocalories i kēlā me kēia lā);
  • nā makahiki o nā keiki.

Pono e mālama ʻia ka hoʻopiʻi ʻana i nā biguanides i nā kānaka he 60 a keu ke ʻano he mau makahiki nui lākou. I kēia hihia, aia ka pilikia nui o ka hoʻomohalaʻana i ka coma comact lactic.

Nā hopena ʻaoʻao a me ka overdose

Ma kahi o 10 a 25 paha ka nui o nā hihia, nā maʻi e lawe ana i nā biguanides e ʻike i nā hopena ʻaoʻao e like me ka mea nui o ka metallic o ka waha, ka nele o ka momona, a me ka hanu. No ka hōʻemiʻana i ka hoʻomakaʻana o ka hoʻomohalaʻana i kahi mau hōʻailona, ​​he mea nui ke lawe i kēia mau lāʻau lapaʻau me a i ʻole hoʻi maʻa o ka ʻai. Pono hoʻonui ʻia ka nui dosage.

ʻO ka Metformin a me ka waiʻona kūpono ʻole. ʻAʻole pono ka mea maʻi e inu i kahi wai o ka waiʻona i ka wā e mālama ʻia ana ʻo ia me nā raina ʻoi e like me ke kō.

I kekahi mau hihia, hiki i ka hoʻomohalaʻana o ka anemia megaloblastic, ka hapa cyanocobalamin. Kuhi loa, ʻike ʻia nā rashes pakanu ma ka ʻili.

I ka hihia o kahi overdose, hele mai nā hōʻailona acidosis lactic. ʻO nā hōʻailona o ke kūlana kēia nāwaliwali, nā pilikia hanu, nā hiamoe, ka puʻuwai, a me nā maʻi. ʻO ka hoʻomoʻoʻana o nā hiʻona, bradycardia, hypotension ka mea kaulana. Hoʻomaʻamaʻa ka mālama ʻana i ka acidosis lactic.


E hoʻomoʻa i ka lāʻau lapaʻau a koho i ke ʻano kūpono wale nō ke kauka

ʻĀnō

Pono ka hoʻonā ʻana o ka lāʻau i kēlā me kēia manawa i kēlā me kēia. Loaʻa mau ʻoe i kahi glucometer ma ka lima. He mea nui hoʻi ia e noʻonoʻo pono i nā pōmaikaʻi: pinepine nā hopena ʻaoʻao i ka ulu wale ʻana ma o ke ʻano kūpono ʻole.

Pono e hoʻoulu ʻia ka hānai me nā biguanides ma kahi haʻahaʻa haʻahaʻa - ʻaʻole iʻoi aku ma mua o 500-1000 g i kēlā me kēia lā (no kēlā, 1 a me 2 mau papa o 0.5 g). Inā ʻaʻole i ʻike ʻia nā hopena kūpono, a laila hiki ke hoʻonui ʻia ke ʻano. ʻO ka nui loa o ka lāʻau i ka lā he 3 grama.

No laila, he maikaʻi maikaʻi loa ʻo Metformin no ka mālama ʻana a me ka pale ʻana i ka maʻi maʻi. Pono e hahai pono i ka ʻōlelo aʻo no ka hoʻohana ʻana i ka lāʻau lapaʻau.

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