ʻO Cholesterol ka pūpū o nā mea kūlohelohe, kahi polycyclic lipophilic alkohol, kahi ma o nā membranes o ka kokoke o nā mea ola ola āpau.
Kāhea ʻole Cholesterol ma ka wai. Hoʻopau ʻia kēia mea i nā momona a me nā hoʻokaʻawa organik.
Ma kahi o 4/5 o ka kolamu e pono ai e ke kino e hua ʻia e ke kino ma luna o ia iho. Kuhi ʻia kēia pūlima e nā ʻāpana ʻili. Loaʻa i ke kino ka nalo 1/5 o ka nui o ka mana o ka pūhui mai ka hana i waho mai ka wā o ka meaʻai me nā mea ʻai.
ʻO ke kuleana ola o ke kolamu ma ke kino
ʻIke ʻia ka mea kanu i loko o ke kino i nā ʻano ʻelua. ʻO kēia mau ʻano o ka pūhui i kapa ʻia nā lipoproteins density kiʻekiʻe a haʻahaʻa haʻahaʻa.
Mālama ka mālama iā ia i ka pale ʻana o nā membrane membran i nā loli.
Hoʻokomo ʻia ʻo Cholesterol ma ke kōpana ʻana o ka nui o nā mea hoʻohui biologically active.
Hoʻokomo ka mea i loko o nā hana penei:
- ʻO Cholesterol he cell membrane fluidity stabilizer.
- Hoʻokomo i ka synthesis o nā hormone sex steroid.
- ʻO ia kahi māhele i komo i ka hana o corticosteroids.
- ʻO Cholesterol ke kumu no ka hoʻopili ʻana o nā waikahe bile.
- ʻO ka mea hoʻomalu i hoʻokahi o nā mea i komo i ke kāpili ʻana o ka vitamina D.
- Hāʻawi i ka permeability o nā membranes.
- Mālama i ka hopena o nā poʻipoʻi hemolytic ma nā pehu ʻōpū.
No ka hē ʻole o ka kolamu ma ka wai, i ka hoʻohui ʻana o ke koko i loko o kahi pūpili paʻakikī me nā protein transporter kūikawā, hana i nā paʻakikī - lipoproteins.
Ke lawe nei i ka lawe ʻana i nā ʻāpana peripheral o ke ʻano e ka chylomicron, VLDL a me LDL.
ʻO ke komo ʻana i nā ʻano kūlike metabola, ua synthesize ʻia ka derivatives cholesterol kikoʻīpiha i loko o ke kino o ke kanaka.
ʻO nā kumu kumu nui o ka cholesterol he mau lakua bile, nā mika steroid, ka vitamin D a me nā cholestanos.
Hoʻokomo kekahi o nā pūhui kemika i ka hāʻawi ʻana i ke pale palekana o ke kanaka. Mālama lākou i nā maʻi ākea ākea.
Nā hana i kahi hua Bile
Hoʻopilikia ka kolesterol i ke kino i ka maʻi hoʻōlaʻa. Hoʻohuli ʻia i nā ʻano like like ole o ka steroid. Ma kahi o 70% o ka nui o ka loaʻa ʻikepili manuahi manuahi e hana ai i kahi kaʻina.
Ke lawe ʻia nei ka hana o nā waikā bile e nā ʻili o nā pepi. Lawe ʻia ka ʻike a me ka mālama ʻana i nā waikahe bile. Inā pono, e lawe ʻia lākou i loko o ka lumen o ka pahu liʻiliʻi.
Hoʻokomo kēia derivative o ka cholesterol i ka hana hāhai.
ʻO ka mea nui i waena o nā waikawa bile he chulate acid. Hoʻopili i kēia mea hoʻohui, ua hoʻohua ʻia nā derivatives e like me deoxycholic, chenodeoxycholic and lithocholic acid i loko o ka ate. ʻO ka ʻāpana, ua loaʻa kēia mau waikawa ma ke kikoo i ke ʻano o nā paʻakai.
ʻO kēia mau māhele nui nā hua bile. Hāʻawi ka poʻe derivatives i ka luku ʻia o nā lipids.
Nā Hormones derivatives o Cholesterol
Hoʻopili i ke komo ʻana i ka hana o nā waikahe bile, ua komo ka cholesterol i ka hoʻopili ʻana o ka nui o nā hormone.
Hoʻokomo ʻia nā Honeone me ka komo ʻana o ka palaka lipophilic polycyclic e hoʻoponopono i nā hana maʻamau o ke kino.
He aha nā hormon e kū i ka wā o ka metabolism?
Aia nā kumumana o kēia pūhui kemu me 5 mau papa papa o nā hormones steroid.
- progestins;
- nā glucocorticoids;
- mineralocorticoids;
- androgens;
- estrogens.
ʻO ka Progesterone i hui pū me ka progestogen e hoʻoponopono i ka hoʻomākaukau o ka ʻōpū no ka implantation o kahi hua i kanu ʻia.
Eia kekahi, koi ʻia ka progesterone no ka papa maʻamau o ka hāpai ʻana. ʻO Progesterone i hui pū me nā hormone ʻē aʻe ke kuleana no ka hōʻoia ʻana i kahi kanaka e hoʻokō piha i kāna hana hānau. ʻO kekahi o nā derivatives o ka cholesterol e hāʻawi ana i ka hoʻopau piha o nā hana kāne e ke kino he testosterone.
ʻO nā ʻōmaʻomaʻo mai ka pūʻulu o androgens e kuleana no ka hoʻomohala ʻana i ke ʻano o ka pilikino male, a pili nā estrogens i ka ʻike a me ka hoʻomohala ʻana i nā hōʻailona ma ka wahine.
ʻO ka Glucocorticoids e komo i ka hoʻopili o ka glycogen a hāʻawi i ke kaomi ʻana i nā hopena hoʻonāola i ka foci o ke ʻano hanana e kū ana ma ke kino o ke kanaka.
Hoʻopilikia ka Mineralocorticoids i ka hana o nā keiki. Ma muli o kā lākou hopena i ke piʻi ʻana o ke kahe koko i kēia mau kino a me ka hoʻonui o ke kahe koko.
ʻO ke ʻano o ke kanaka a me kona kūlana e pili ana i ka neʻe ʻana a me ka noʻonoʻo o ka endorphins, ʻo ia hoʻi nā hormon o ka hauʻoli. ʻO kēia mau mea hana biologically kūlohelohe kekahi mai hakahaka polycyclic lipophilic alkohol.
ʻO kahi hiʻohiʻona o nā hormones steroid ka mea hiki iā lākou ke komo maʻalahi i ka membrane cell a me ka hiki ke kamaʻilio pū me nā mea kikoʻī kūikawā i ka cytoplasm a i ʻole ke kiko o ka mea i hoʻopaʻa ʻia.
Ke lawe ʻia nei nā hormone Steroid me ke kahawai koko kahi lākou e hoʻopili ai i nā mea paʻakikī me nā protein o ka hoʻokele kūikawā.
ʻO ka waiora D a me nā cholestanos
ʻO ka ʻōmole lipophilic Polycyclic kahi mua o ka huaora D. ʻO kēia meaola lāʻau eola ai i hana nui no ka hōʻoia ʻana i ka hana maʻamau o ke kino. Loaʻa kēia māhele i ka hana o ka calcium a me ka phosphorus. Pono ʻia kēia mau mea no ka hana maʻamau ʻana i nā iwi iwi.
I ka hopena o nā kaʻina metabola, ua hoʻololi ʻia ka vitamin D i ka calcitriol. Ma hope mai, hoʻopili ʻia kēia pūlehu i nā pū i nā ʻokoʻa kūikawā a hoʻoponopono i ka hana ʻana o nā ʻano genes. Me ka loaʻa ʻole o ka nui o ka huaora D i ke kino, ʻike ka hoʻomohala ʻana o nā rickets i ka wā kamaliʻi.
ʻO kekahi mea hānō o ka waiʻona lipophilic polycyclic he cholestanos. ʻO kēia pūʻulu huahana he hui o nā steroid. Hōʻike ʻia ka ʻike o kēia mau mea ma nā kime adrenal, ma loko o ia mea e hōʻiliʻili ai. I kēia manawa, ʻaʻole maopopo ka hana o kēia ʻāpana.
Ka hoʻololi ʻia o ke kololi i loko o ke kino i kahi nui o nā mea hoʻohui ʻola biologically. Pono e hoʻolilo i ka mea nui i waena o lākou i nā huaʻōlelo i mea e paʻa ai nā hua bile. Ua hana kēia mau pūhui i mea e lawelawe ai i ka emulsifying a ma hope o ke komo ʻana i ka ʻōpū, komo i ka ate, mai kahi e hiki ai ke hana hou ʻia. Hāʻawi kēia mau māhele i ka hāhai ʻana a me ka haʻihaʻi ʻana o nā momona i ka meaʻai i ka wā o ka hoʻoneʻe ʻana.
E pili ana i ka metabolism cholesterol i wehewehe ʻia i ke wikiō ma kēia ʻatikala.
