ʻO Octreotide kahi analogue synthetic o ka lāʻau Somatostatin, he like ia i nā huahana pharmacological like pū, akā hiki ke lōʻihi kahi hana. E kōkua ana ka lāʻau lapaʻau e hōʻoki i ka hoʻonuiʻana i ka pathologically i hoʻonui i ka ulu o ka ulu ulu, insulin, serotonin, gastrin, glucagon, thyrotropin.
Hoʻohālikelike ʻia i nā mea kūlohelohe somatostatin, kahi lāʻau lapaʻau syntpresses i ka huna ʻia o ka mea ulu ʻana o ka ulu ʻana o ka ikaika ma mua o ka hormone hormone. Me ka acromegaly, nā poʻo nui, ke kūleʻe nei i loko o nā ʻāpana palupalu, hyperhidrosis, ʻeha pūwā, hōʻemi ʻia ka paresthesia. ʻO ka nui o ka ʻōpū i loko o ka adenomas pituitary nui e hoʻēmi.
Hoʻomaikaʻi hoʻi ʻo Octreotide i ka papa o ka maʻi ma hope o ka hōʻemi ʻana, ka chemotherapy, embolization o ka arela hepatic. Inā he mau peʻa carcinoid, hōʻemi ka lāʻau lapaʻau i ka hoʻomaka ʻana o ka serotonin i loko o ke koko, e hoʻopau i ka maʻi maʻi a me ke kahe o ke koko i ka maka.
Nā hana lāʻau
I mua o kahi maʻi maʻi pancreatic i hoʻokumu ʻia e nā peptides vasoactive intestinal, hōʻemi ka hopena huna secretory a ma ke ʻano, he ʻano maikaʻi ke ʻano o ka mea maʻi. I kekahi mau hihia, e lohi a hoʻōla paha nā mea hoʻonaninani i kahi keaka holomua, hōʻemi i kona nui a hoʻemi i ka ʻike ʻana o nā peptides i ka plasma.
ʻAʻole pili ka lāʻau lapaʻau i ka pae o ka glucose i ke koko ma mua o ka maʻi mellitus, no laila, pono e hoʻomanawanui hou ka mea maʻi i nā lāʻau haʻahaʻa a hoʻʻaʻahaʻa. Ua hōʻoluʻolu ʻo Octreotide i nā hōʻailona o ka maʻi maʻi, aʻo ia ka manawa like me ka loaʻa ʻana o ka momona o ke kanaka.
Me ka hōʻike ʻana o ka maʻi Zollinger-Ellison, hiki i ka lāʻau lapaʻau ke hōʻemi i ka hana o ka waikila hydrochloric i loko o ka ʻōpū, hoʻoemi i ka pae o gastrin i ke koko, a hōʻoluʻolu i ka maʻi maʻi a me ka hoʻoluhi nui i ke koko. Hiki ke hoʻokō ʻia ka lāʻau lapaʻau ʻole a hui pū ai me nā lāʻau ʻē aʻe i ʻōlelo ʻia e kekahi kauka.
- Inā he insulinoma, ʻoi aku ka hopena o ka lāʻau lapaʻau i ka insulin immunoreactive i loko o ke koko, akā ʻo ka hopena therapeutic he pōkole ke lōʻihi a lōʻihi ka manawa i hala aku i ʻelua mau hola. I ka wā preoperative, i nā poʻe me ke koikoi operable, ua mālama hou ʻo Octreotide i ka mālama ʻana i ka maʻi glycemic.
- I ka hiki ʻana o kahi tumi ka hopena i hoʻoulu ʻia e nā ulu lāʻau, ua hoʻemi ʻia nā hōʻailona o ka acromegaly e ka hoʻomake ʻana i ka hana o nā mea hormonal. I ka wā e hiki mai ana, alakaʻi i ka mālamaʻana i ka hypertrophy pituitary.
- I ka wā e hōʻike ai i ka maʻi immunodeficiency, ʻo ka lāʻau lapaʻau ka ʻokoʻa a hapa ʻole i ka papaʻa, i kū ʻole mau i ka lāʻau antimicrobial a antidiarrheal.
- Inā hoʻolālā ʻoe e hana i ka pancreas, lawe ʻia ʻo Octreotide i mua a ma hope o ka hoʻomaʻamaʻa ʻana. Hoʻopaku kēia i ka hōʻeha o nā hoʻopiʻi postoperative i ke ʻano o ka pancistatic fistula, abscess, pancreatitis acute.
Eia kekahi, ʻo ka hana kiʻekiʻe o ka lāʻau lapaʻau ua hōʻike ʻia i mua o ka cirrhosis. Kūleʻa koke ke maʻi i ke kahe mai ka varicose vein a me ka esophagus, a hoʻomaikaʻi pū i ke ʻano maʻamau o ka mea maʻi. Hoʻopili ʻia nā mea lapaʻau i loko me ke ʻano o nā hana nui o ka mālama ʻana.
Ma keʻano holoʻokoʻa, loaʻa nā loiloi maikaʻi i nā loiloi mai nā kauka a me nā maʻi.
Ke hoʻohana nei i ka lāʻau
Ma hope o ke ʻano e hoʻohālikelike ʻia ai e ke kauka, e mālama maikaʻi ʻia a e ʻāʻī, i ka wā koke. Ka ʻike kiʻekiʻe loa o ka waiwai ikaika ma ka plasma koko i mālama ʻia i ka hapalua hola ma hope o ka pauʻana o ka lāʻau lapaʻau.
Inā hoʻokō ʻia ka hoʻonā ʻāleʻa subcutaneously, ua hoʻopau ʻia ʻo Octreotide mai ke kino hoʻokahi a me ka hapa hola ma hope o ka paʻi ʻana. Me ka injra intravenous, hele ʻia ka excretion i ʻelua mau manawa, ma hope o 10 a me 90 mau minuke. Hoʻokuʻu ʻia ka manaʻo koʻikoʻi ma o nā ʻōpū, a me ka hapakolu o nā mea ma o nā hua.
ʻO ka huina holoʻokoʻa o ka hōʻemi ʻana i ka lāʻau mai nā umauma kino he 160 ml i hoʻokahi minuke. I ka manawa like, i nā poʻe kahiko, hoʻomaʻemaʻe mālie ke koko no ka nui o ka hapalua ola. Me ka hōʻike ʻana o ka pilikia ʻole o ka hana ʻole o ke aʻalolo, hoʻomaʻemaʻe ʻia hoʻi ke lilo i ʻelua hapa.
Hoʻohana ʻia ka lāʻau lapaʻau ikaika no:
- ʻO Acromegaly e hoʻomalu i nā hōʻike nui o ka maʻi a hoʻohaʻahaʻa i ka pae o ka ulu ulu ʻana ke wā e loaʻa ai ka hoʻomaʻamaʻi a me ka maʻi radiation ka hopena i makemake ʻia;
- ʻO ka pancreatitis akue a me kahi mea hoʻokalakupua ma hope o ka hoʻomaʻamaʻa ʻana i nā ʻōpū o ka ʻōpū;
- Hoʻopili i kahi hihia o ka ulia peptic o ka ʻōpū a me ka duodenum;
- ʻO ka heleʻana o nā tumomo carcinoid i hui pū me ka maʻi carcinoid;
- ʻO nā hana o nā pancreas e hana ana i nā peptides intestinal vasoactive;
- ʻO Zollinger-Ellison syndrome e hui pū me nā lāʻau pilikino;
- Kuhi ʻia e ka glucagon, insulin, somatoliberin.
He mea nui e hoʻomaopopo he pili ʻole ka lāʻau lapaʻau i nā lāʻau lapaʻau e hōʻolo i nā maʻi ʻaʻi, no laila hiki ke hoʻohana ʻia e like me ka hoʻohui i ka regimen lapaʻau koʻikoʻi. Hiki i ka Octreotide ke pani pono i ke koko me nā varicose veins o ka ʻōpū a me ka esophagus i nā poʻe me kahi maʻi o ka cirrhosis.
ʻAʻole hiki ke hoʻohana ʻia ka lāʻau lapaʻau ma ka mālama ʻana i nā keiki a me nā ʻōpio i lalo o nā makahiki 18. Eia kekahi, contraindications kekahi hypersensitivity i nā māhele o ka lāʻau. Pono e mālama pono ʻia inā he maʻi mellitus a me ka maʻi gallstone kekahi kanaka. Ma mua o ka hoʻohana ʻana i ka lāʻau lapaʻau, pono nā wahine hāpai a me nā wahine lactating e nīnau aku i kā lākou kauka.
Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau
ʻO Octreotide kahi hopena kūpono no ka wai hoʻonaninani no ka intravenous a me ka subcutaneous injection. Kūʻai ʻia ka lāʻau lapaʻau i loko o nā pahu me kahi kaila o 50, 100, 300 a me 600 mcg
ml, hilinaʻi ia i ka nui o nā ampoules a me nā kiko o ka mea e hana ai i 1 ml.
ʻO nā mea kūleʻa he wai no ka injection a me ka sodium klorida. Oe ke kuai i ka hopena i loko o kekahi lāʻau lapaʻau ma ka hōʻike ʻana i ke kaukau ʻana o ke kauka.
Me ka ʻōkuhi subkutaneus, pono e nānā pono ka ampoule i loaʻa ʻole i ka hopena o ka hopena. E hoʻomehana i ka wai me ka mahana o ka lumi. E wehe koke i ka ampoule ma mua o ke kōkō, hoʻokuʻu ʻia ke koena e waiho ʻia. Pono e hana ʻia kēia maʻi ma nā ʻāpana like ʻole o ke kino a i ʻole e hōʻeha i ka ʻeha ma luna o ka ʻili.
- No ka hoʻokō intravenous e hoʻohana ana i kahi dropper, hoʻoheheʻe ʻia ka ampoule me 0.9% sodium chloride ma mua o ke kaʻina hana. ʻAe ʻia ka paʻakai e mālama ʻia i loko o ka friji i ka lā ma lalo o nā kūlana wela o ka 2-8 degere.
- Inā aia ka pancreatitis kūleʻa, ke mālama ʻia kahi nui o 100 μg e ka subcutaneously ʻekolu mau manawa o ka lā no nā lā ʻelima. ʻO nā meaʻokoʻa loa, hiki ke hoʻonui ʻia ka nui o ka lā i kēlā me kēia lā i 1200 mcg.
- Ma hope o ka wehe ʻana i ka pancreas, hoʻohana ʻia ka lapaʻau subcutaneous o 100-200 mcg. E mālama ʻia ka dosage mua ʻelua mau hola ma mua o ka hoʻomaʻamaʻa ʻana, a laila ma ka wā postoperative, ua hoʻolilo ʻia kahi maʻi i ʻekolu manawa i ka lā no kahi pule.
- Ke hooki nei i ke koko ulcerative, hana ʻia ka maʻi infusion me i loko o intravenously. Ma luna oʻelima mau lā, mālama ʻia ka mea maʻi i 25-50 mcg i kēlā me kēia hola. Pēlā nō, hoʻokō ʻia ka hana maʻi no ke koko mai nā varicose veins o ka ʻōpū a me ka esophagus.
Me ka acromegaly, ʻo ka maʻa mua he 50-100 μg, mālama ʻia ka hopena i kēlā me kēia ʻewalu a i ʻole ʻumikūmālua mau hola. Inā ʻaʻole i ʻike ʻia kahi hopena maikaʻi, e piʻi ana ka make i 300 mcg. Loaʻa ka lōʻihi o hoʻokahi lā e hoʻohana ʻia ʻaʻole ma mua o 1500 mcg o ka lāʻau lapaʻau.
Inā ma hope o ʻekolu mau makahiki, ʻaʻole i emi ka pae o ka hormone ulu, ua kāpae ʻia ka lāʻau lapaʻau a hoʻololi ʻia i kahi like like.
Nā hopena hopena
Loaʻa ka lāʻau lapaʻau i nā hopena pili. I ka manawa pinepine, i ka wā o ka mālama ʻana, hiki i nā maʻi ke hōʻeha i nā hōʻailona ma ke ʻano o ke kīnā ʻole a constipation, nausea, bloating, a me ka ʻeha i loko o ka ʻōpū.
Hoʻololi ka kala o ka papaʻa, me nā momona keu he nui ka momona, hoʻokuʻu ʻia ka ʻōpū a ikaika. E maʻule ka ʻaihue, aia nā pua o ka luaʻi, ke hoʻopilikia ʻia ke kaʻina o ke aihue, hoʻemi ka nui o ka paona.
Eia kekahi, hiki i ke kauka ke hoʻokolokolo i ka cholelithiasis, cholecystitis, hyperbilirubinemia. Hōʻea ka Colloidal stabilile o ka hua palaoa, ma muli o ia mea i hoʻokumu ʻia ai ke microcrystals o ka cholesterol. Hoʻohui hiki ke hōʻike i ka bradycardia, a i kekahi mau hihia - tachycardia.
- Ma waena o nā hopena ʻokoʻa, hiki ke hoʻākāka ʻia ka hyperglycemia a me ka hypoglycemia, ke kuhi ʻia ka ʻōmaʻi o ka thyroid.
- Hiki i kahi kanaka ke ʻeha ma ke pōkole o ka hanu, ka ʻeha, ka maʻi maʻamau.
- Pōreʻe ka ʻū a me ka ʻeha i ka ʻili, ulu ka ulu, a i kekahi manawa hāʻule nā lauoho. I ka wahi e ʻōlelo ai, hiki paha ke kaumaha.
Me ka nui o ka hypersensitivity, e ulu ka hopena anaphylactic. Hoʻokomo ʻia kekahi poʻe i ka arrhythmia. Akā ke manaʻo ʻia nei he mau mea kaawale, ʻoiai ʻaʻole i ʻike ʻia kahi pilina kumu o nā mea kū like.
Kōkua ʻo Octreotide e hōʻemi i ka lawe ʻana o ka lāʻau Cyclosporine, hoʻonui i ka bioavailability o ka bromocriptine, e hoʻolohi i ka lilo ʻana o cimetidine, hōʻemi i ka hana o ka lāʻau lapaʻau e hoʻōla ai i nā huila cytochrome P450.
Inā hana ʻoe i ka manawa like i ka therapy insulin, e mālama me nā mea laʻa hypoglycemic waha, glucagon, nā alaka a me nā kalaka, nā beta-blockers a me nā diuretics, pono nā hoʻoponopono ʻia.
I mea e pale aku ai i nā hoʻopiʻi, i ka wā o ka papa hana pono i ka hoʻoponopono ʻana i ka ʻōnaehana ʻana i ka pae o ke kōpaʻa koko, me ka nui o ke kuana ʻana o nā kaʻe no ka maʻi varicose o ka esophagus a me ka cirrhosis o nā ate.
Hoʻonui kēia mau ʻōuli i ka ulu o ka nui o ka piʻi o ka glucose.
Nā kikowaena o Octreotide
Nui nā lāʻau lapaʻau he hopena like paha ma ke kino. Hoʻopili kēia me ka lāʻau lapaʻau Sermorelin, Sandostatin, Octrid, Genfastat, Diferelin. ʻO Generics Octreotide Depot a me Octreotide Long he like nō me ka mea like.
Kūlaʻi ke kumukūʻai i ka mea hana, ka nui a me ka nui o nā ampoule i loko o ka paʻi, ma loko o kahi hale kīnā ke kumukūʻai o nā lāʻau lapaʻau e like hoʻi mai 600 a 3500 rubles.
Loaʻa ka hoʻonā i ka wahi maloo, kahi mamao loa i nā keiki a me ka lohi o ka lā. ʻO ke kūlana no ka mālama ʻana i ka lāʻau lapaʻau he 8-25 kiʻekiʻe. ʻAʻole ʻoi aku ka ʻelima o ke ola ma kahi o ka ʻelima mau makahiki, a ma hope o ke kuʻi ʻia ʻana o ka hoʻonā, inā ʻaʻole i wehe ʻia.
Pehea e mālama ai i ka maʻi kanesa o ka pancreas i hōʻike ʻia ma ke wikiō i kēia ʻatikala.
