ʻO Tricor kahi lāʻau lapaʻau lipid-kaila i hoʻohana ʻia no ka dyslipidemia, a hoʻohana ʻia nō hoʻi no ka maʻi maʻi, inā eʻai maikaʻi ka mālama ʻana i ka ʻai.
ʻO ka lāʻau lapaʻau e hoʻohaʻahaʻa i ka pae o ka fibrinogen a me ka kiko o nā hapa atherogenic o ka kolamu ma ke koko (VLDL, LDL), e hoʻonui ana i ka hoʻonuiʻana i ka waikū uric.
E hoʻokuʻu i ke ʻano a me ka ʻano
Kuhi ʻia aku ʻo Tricor ma ke ʻano o nā papa kiʻi ʻoniʻoni ma loko o kahi pānaʻi o 30 mau papa. Aia i kēlā me kēia papa pākuʻi micronized fenofibrate 145 mg, a me nā mea aʻe:
- laktosa lactose,
- sodium lauryl sulfate,
- huehue
- hohaihono,
- silika
- crospovidone
- sodium palapala.
Hoʻolaha hopena
ʻO Fenofibrate kahi huaʻala o ka waikawa fibric. Ua hiki ke hoʻololi i nā pae o nā māhele like ʻole o nā lipids ma ke koko. Ke hōʻike nei ka lāʻau lapaʻau i kēia ʻano hōʻike:
- Hoʻonui nā hoʻomaʻemaʻe
- Hoʻemi i ka nui o nā lipoproteins atherogenic (LDL a me VLDL) i nā mea maʻi me ka nui o ka pilikia o ka maʻi naʻau coronary,
- E hoʻonui i ka pae o ka "maikaʻi" cholesterol (HDL),
- Hoʻonui koʻikoʻi i nā mea o nā waihona kolikola extravascular,
- ʻO ka hoʻololi ʻana o ka fibrinogen,
- Hoʻemi i ka nui o ka waikika uric i ke koko a me ka protein C-reactive.
ʻO ka pae kiʻekiʻe o ka fenofibrate i ke koko kanaka ke nānā i kekahi mau hola ma hope o ka hoʻohana. Ma lalo o ke kūlana o ka hoʻohana mau ʻana, ʻaʻohe hopena kumulā.
ʻO ka lilo ʻana o ka lāʻau lapaʻau Tricor i ka wā hāpai
Ua hōʻike ʻia kahi ʻike liʻiliʻi e pili ana i ka hoʻohana ʻana o ka fenofibrate i ka wā hāpai. I nā hoʻokolohua ma luna o nā holoholona, ʻaʻole i hōʻike ʻia ka hopena teratogenic o ka fenofibrate.
Ua hele ʻia ʻo ka Embryotoxicity ma ke ʻano he hopena o ka hoʻokaʻawale ʻana i nā hihia i hiki ke waiho ʻia i ke kino o ka wahine hāpai. I kēia manawa, ʻaʻohe pilikia o nā kānaka. Eia naʻe, hiki ke hoʻohana ʻia ka lāʻau lapaʻau i ka wā o ka hapai i ka loiloi ʻana o ka loiloi e pili ana i ka hoʻohālikelike o nā pōmaikaʻi a me nā hopena o nā pilikia.
No ka mea ʻaʻohe hua kūpono e pili ana i ka palekana o ka lāʻau Tricor i ka wā o ka hoʻoulu ʻana, a laila i loko o kēia manawa ʻaʻole ia i kuhikuhi ʻia.
ʻO nā contraindications e lawe aku nei i ka lāʻau lapaʻau Tricor o nā:
- He kiʻekiʻe ka manaʻo o ka sensitofibrate a me nā meaʻokoʻa'ē aʻe o ka lāʻau;
- ʻO ka hōʻoleʻana o ka renal maikaʻi ʻole, no ka laʻana, cirrhosis o ka ate;
- 18 makahiki;
- ʻO ka mōʻaukala photosensitization a i ʻole phototoxicity i ka mālama ʻana i ka ketoprofen a i ʻole ketoprofen;
- Nā maʻi like ʻole o ka pīpī;
- Pue; male;
- ʻO Galactosemia endogenous, ʻaʻole lawa o nā lactase, ka malabsorption o ka galactose a me ka glucose (ʻo ka lāʻau lapaʻau ka lactose);
- ʻO ka fruktosaemia Endogenous, ka hapa sucrose-isomaltase (loaʻa i ka lāʻau lapaʻau ka sucrose) - Tricor 145;
- He hopena maʻi kūloko i ka pata pīpī, ka pīa, soya lecithin, a i ʻole ka moʻolelo like ʻole o ka meaʻai (ʻoiai he hanana ka hypersensitivity).
Pono e hoʻohana i ka huahana me ka akahele, inā loaʻa:
- Ka Renal a me / a ʻole kaulike pale;
- Hoʻohālikelike waiʻona;
- Hypothyroidism;
- ʻO ka mea maʻi ma ka ʻelemakule;
- ʻO ka mea maʻi i ka mōʻī kaumaha ʻo ia i ka pili me nā maʻi pūpū hoʻoilina.
ʻO nā helu o ka lāʻau a me ke ʻano o ka hoʻohana ʻana
Pono e lawe ʻia ka huahana pono ʻole, ke kīnā a piha i ka nui o nā wai. Hoʻohana ʻia ka papa papa i kēlā me kēia manawa o ka lā, ʻaʻole ia e hilinaʻi ma ka kōʻai meaʻai (no Tricor 145), a i ka manawa like me ka meaʻai (no Tricor 160).
Lawe a makua pākahi 1 papa i hoʻokahi lā i ka lā. ʻO nā mea maʻi e lawe ana i 1 mau kapsul o Lipantil 200 M a i ʻole 1 papa o Tricor 160 i kēlā me kēia lā ke hoʻomaka e lawe i ka 1 papa o Tricor 145 me kahi loli hou ʻole.
ʻO ka mea maʻi e lawe i ka 1 mau kapsul o Lipantil 200 M i kēlā me kēia lā ka manawa kūpono e hoʻohuli i ka 1 papa o Tricor 160 me ka loli ʻole o ka nui.
Pono nā poʻe maʻi e hoʻohana i ka dosis maʻamau no nā pākeke: 1 papa o Tricor hoʻokahi lā i ka lā.
ʻO nā maʻi me ka pilikia ʻole e hōʻemi i ka pume ma ka nīnau ʻana i kahi kauka.
E nānā: ʻaʻole i aʻo ʻia ka hoʻohana ʻana o ka lāʻau Tricor i nā mea maʻi me ka maʻi ʻōlohelohe. ʻAʻole hāʻawi nā hōʻike i ke kiʻi maʻa.
Pono ka lawaiʻa e lawe ʻia i ka wā lōʻihi, ʻoiai ke nānā aku nei i nā papa kuhikuhi no ka papaʻai a kekahi kanaka i ukali ma mua o ka hoʻomaka ʻana e hoʻohana i ka lāʻau. ʻO ka pono o ka lāʻau lapaʻau e pono e loiloi e ke kauka hele mai.
ʻImi ʻia ka hoʻomaʻamaʻa ʻia e nā pae serid lipid. Ke kamaʻilio nei mākou e pili ana i ka LDL kolamu, ka nui o nā cholesterol a me nā triglycerides. Inā ʻaʻole i loaʻa ka hopena therapeutic i loko o kekahi mau mahina, a laila e kūkākūkā ʻia ke koho hou ʻana.
ʻO kahi lāʻau hoʻonui nui
ʻAʻole wehewehe i nā hihia overdose. Akā inā kānalua ʻoe i kēia ʻano, hiki iā ʻoe ke hoʻokō i ka hōʻailona a me ke kākoʻo kākoʻo. ʻAʻole maikaʻi ʻia ʻo Hemodialysis ma aneʻi.
Pehea ka pili o ka lāʻau lapaʻau me nā lāʻau ʻē aʻe
- Me nā anticoagulants waha: fenofibrate e hoʻonui i ka pono o ka anticoagulants waha a hoʻonui i ka nui o ka ʻahe. ʻO kēia no ka neʻe o ka anticoagulant mai nā pūnaewele kīmika plasma.
I nā hoʻomaka mua o ka mālama fenofibrate, pono ia e hōʻemi i ka nui o nā anticoagulants e ke kolu, a koho mau i kahi puʻupuʻu. Pono ke koho i ka maʻa ma lalo o ke kaohi o ka pae INR.
- Me ka cyclosporine: aia nā wehewehe o nā hihia koʻikoʻi o ka hoʻemi ʻana i ka hana ate i ka wā o ka mālama ʻana me ka cyclosporine a me fenofibrate. Pono e kiaʻi pinepine i ka hana ate i loko o nā mea maʻi a hoʻoneʻe i ka fenofibrate inā loaʻa nā loli koʻikoʻi i nā kaulike laboratorium.
- Me ka HMG-CoA reductase inhibitors a me nā fibrates ʻē aʻe: i ka wā e lawe ana i ka fenofibrate me ka HMG-CoA reductase inhibitors a i nā fibrates ʻē aʻe, i noho ka hopena o ka hoʻohuihui ma nā uaua o ka naʻau.
- Me nā pūmeni cytochrome P450: e hōʻike ana nā haʻawina o nā mikrosome i nā kānaka i ka huehue fenofibroic a me ka fenofibrate ʻaʻole e hana i ka mea o ka pale o kēlā cytochrome P450 isoenzymes:
- CYP2D6,
- CYP3A4,
- CYP2E1 a i ʻole CYP1A2.
I nā dosage therapeutic, ʻo kēia mau pūhui nāwaliwali nā hema o nā isoenzymes CYP2C19 a me CYP2A6, a i ʻole ka hōʻemi a me ka mea hōʻemi CYP2C9 inhibitors.
Kekahi mau ʻōlelo aʻoaʻo kūikawā i ka wā e lawe ai i ka lāʻau
Ma mua o ka hoʻomaka ʻana i ka hoʻohana ʻana i ka lāʻau lapaʻau, pono ʻoe e hana i ka lāʻau lapaʻau e kuhikuhi ana i ka hoʻopau ʻana i nā kumu o ka hypercholesterolemia kūloko, ke kamaʻilio nei mākou e pili ana:
- keʻa kūpaʻa type 2
- hypothyroidism
- ʻālaʻi nephrotic
- kūlia
- maʻi maʻi pāpaʻi
- nā hopena o ke ʻano lāʻau lapaʻau,
- waiʻona.
ʻImi ʻia ka hopena o ka mālama ʻana i nā kiko o nā lipids.
- huʻeluʻi kolamu
- LDL
- serum triglycerides.
Inā ʻaʻole i ʻike ʻia ka hopena therapeutic no ʻoi aku ma mua o ʻekolu mau malama, pono ia e hoʻomaka i ke ʻano hou a i ʻole ka concomitant therapy.
ʻO nā maʻi me ka hyperlipidemia e lawe i ka contraceptives hormonal a me nā estrogens e pono e ʻike i ke ʻano o ka hyperlipidemia, hiki iā ia ke kumu mua a pae paha. I kēia mau hihia, hiki i ka nui o ka nui o nā lipid ke neʻe ʻia e ka hoʻokomo o ka estrogen, i hōʻoia ʻia e nā loiloi maʻi.
Ke hoʻohana nei ʻo Tricor a i nā lāʻau lāʻau ʻē aʻe e hōʻemi i ka neʻe ʻana o nā lipids, hiki i kekahi mau mea maʻi ke loaʻa i ka hoʻonui ʻana o ka nui o ka transaminases hepatic.
I nā manawa he nui, he liʻiliʻi a hoʻonui ʻole ʻia ka hoʻonui, ʻaʻole i ʻike ʻia nā hōʻailona ʻike ʻole. No nā mahina 12 o ka mālama mua, pono ia e kiaʻi pono i ka pae o nā transaminases (AST, ALT), i kēlā me kēia mau mahina ʻekolu.
ʻO nā mea maʻi i ka wā o ka mālama ʻana, he nui ka neʻe o ka transaminases, e koi pono i ka nānā inā pono ke nānā ʻia o ka ALT a me AST ʻoi a ʻoi paha ka nui o ke kiʻekiʻe o ka paepae luna. I ia kūlana, pono e hoʻōki koke ʻia ka lāʻau lapaʻau.
ʻO ka pancreatitis
Aia ka wehewehe ʻana i nā hihia o ka hoʻomohala ʻana o ka pancreatitis i ka wā e hoʻohana ai ʻo Traicor. ʻO nā kumu kumu o ka pancreatitis:
- ʻO ka nele o ka hopena o ka lāʻau i ka poʻe me ka hypertriglyceridemia koʻikoʻi,
- Ka hōʻike pololei ʻana i ka lāʻau lapaʻau,
- Nā hōʻailona hōʻike e pili ana i nā pōhaku a i ʻole ka hoʻokumu ʻana i ka sediment i loko o ka palaho, ka mea i hui pū ʻia e ka poino o ka wai umauma.
Hoʻoikaika
I ka wā e hoʻohana ai iā Tricor a me nā lāʻau ʻē aʻe e hoʻohaʻahaʻa i ka mālamaʻana o nā lipids, ua hōʻike ʻia nā hihia o nā mea iona e pili ana i ka nui o nā ʻiʻo. Eia kekahi, ua kākau nā hihia lohi o ka rhabdomyolysis.
E hele pinepine kēia mau pilikia inā he mau pilikia o ka pilikia ʻole a i ʻole kahi mōʻaukala o ka hypoalbuminemia.
Nā hopena pōpilikia i ka malu o ka ʻiʻo ke kānalua inā e hoʻopiʻi ka mea maʻi:
- ʻO nā ʻōpū a me nā pahu
- Nā nāwaliwali nui
- E wehewehe i ka myalgia,
- Myositis
- ʻO kahi hoʻonui e hoʻonui ai i ka hana o ka phosphokinase (5 a i ʻole nā manawa i hoʻohālikelike ʻia me ka palena palena kiʻekiʻe o ka maʻamau).
He mea nui ia e ʻike ma loko o kēia mau hihia a pau, e hoʻolaʻa ʻia ka lāʻau me Tricor.
I loko o nā mea maʻi i hoʻomaka ʻia i ka myopathy, i nā poʻe i ʻoi aku ma mua o 70 mau makahiki, a i nā mea maʻi me nā moʻolelo kaumaha, hiki mai paha ka rhabdomyolysis. Eia kekahi, hoʻopiʻi ka ʻano:
- Nā maʻi maʻi ʻōiwi
- Imal
- Hypothyroidism,
- Ka inu maikaʻi ʻana i ka waiʻona.
Ke kuhikuhi ʻia nei ka lāʻau lapaʻau no nā mea maʻi wale nō i ka wā e manaʻo nui ʻia ai ka nui o ka mālama ʻana i nā hanana kūpono ʻole o ka rhabdomyolysis.
Ke hoʻohana pū nei ʻo Traicor me HMG-CoA reductase inhibitors a i ʻole nā fibrates, ʻo ka hopena o ka hopena hōʻeha kino ma luna o nā uaua uaua. He kūpono kēia i ka wā e loaʻa ai i ka maʻi maʻi nā maʻi ʻeha ma mua o ka hoʻomaka ʻana i ka mālama ʻana.
Hiki ke hoʻopili kino ʻia me ka Triicor a me ka statin inā he maʻi nui ko ka dyslipidemia a me kahi hopena kiʻekiʻe o ka puʻuwai maʻi. ʻAʻole pono kekahi moʻolelo o nā maʻi ʻeha. Pono ke kau ʻana i nā hōʻailona o nā hopena o nā hopena o ke kinipona ma o ka ʻōpū o ke ʻano.
Renal hana
Inā hoʻonui ʻia ka hoʻonui ʻana i ka mea i ʻike ʻia ma ka lima o 50% a i ʻole e hoʻopau ʻia, a laila pono e hoʻōki ʻia ka lāʻau lapaʻau. I nā mahina 3 mua o ka hoʻomaʻamaʻa ʻana o Treicor, pono e hoʻoholo ka mea hoʻoulu ʻana i ka loiloi.
ʻAʻole ʻike nā loiloi e pili ana i ka lāʻau lapaʻau e pili ana i nā loli hou i ke olakino i ka wā e lawe ana i ka kaʻa a me ka mālama ʻana i nā mīkini.
