ʻO Glibenclamide kahi lāʻau lapaʻau me nā waiwai hypoglycemic mai ka papa o ka lua o ka hopena o nā kōmia sulfonylurea. Loaʻa iā ia kekahi hopena hypolipidemic a hōʻemi i ka hopena o ka vomb thrombosis.
ʻO keʻano maʻamau
ʻO ka inoa o ka lāʻau lapaʻau Glibenclamide i loko o ka hoʻokūkū o ka honua ma ka Latin ʻo Glibenclamide. ʻO waho, kahi lāʻau lapaʻau he penikala mālamalama mālamalama ma ke ʻano o ka disc a me ka laina hoʻokaʻawale. Hiki i ke kaina ke ʻano he ʻaukā me ka inclusions liʻiliʻi.
Hoʻopili i nā papa ʻaina i loko o nā huki he 10 mau ʻāpana. I loko o kahi pahu e hiki ke lilo i 12 mau papa.
Hoʻokuʻu ʻia ka Glibenclamide ma o ke kumu kūʻai, i mālama ʻia ma lalo o nā kūlana maʻamau, me ka loaʻa ʻole o nā keiki. Nā ʻōlelo i hōʻike ʻia i ke ola o ke ola - 5 mau makahiki. ʻAʻole pono ke lawe ʻia i ka lāʻau lapaʻau.
Aia kēlā me kēlā me kēia papa āpau he 5 mg o ka glibenclamide a me nā mea hanu ma ke ʻano o ka lōmole lactose, kālaiʻai, kāʻai magnesium, polyvinylpyrrolidone, E 124.
ʻO nā ʻoihana kūʻai olakino i hana i kahi mea hoʻohaʻahaʻa huka gula.
- Anti-viral;
- Akrikhin HFK;
- ʻO Bivitech;
- ALSI Pharma;
- Biosynthesis
Hoʻokumu ʻia ia a me ke olakino Ola Ola. No Glibenclamide, ʻo ke kumukūʻai ma ke kaulahao Lūkini Russian 270-350 rubles.
Nā hiʻohiʻona Pharmacological
Pharmacodynamics o ka lāʻau
ʻO ka lāʻau lapaʻau hypoglycemic oral. Ma Glibenclamide, ua kau ʻia ke ʻano o ka hana i ka hoʻoulu ʻia ʻana o ka hana insulin e ka pancreatic β-cells. I ka manawa like, hoʻonāukiuki ka pale o ka insulin o nā io o nā peripheral. Hana nā lāʻau lapaʻau inā loaʻa nā ikaika β-cell ikaika i ka pancreas e hana ai i ka hormone endogenous. Hoʻemi i ka lāʻau lapaʻau a me ka hoʻohui platelet.
Nā hiʻohiʻona Pharmacokinetic
Mai ka wahi gastrointestinal ma hope o ke kaʻina waha ma luna o kahi ʻōpū ʻole, hoʻopili koke ʻia ka lāʻau lapaʻau, nakinaki ia i nā protein koko i ka 95%. Ke hoʻohuli ʻia ka loli o ka waiwai ikaika i loko o nā hana kūlohelohe o ke kūpaʻa. E kāohi ʻia ka ʻōpala e nā keiki a me nā kumu bile. ʻO ka hapalua kēia mai ke kahe koko mai a hoʻokahi a i ka hapa a ʻekolu a me ka hapa. Mālama ke kō i hoʻokahi wai o ka lāʻau no ka liʻiliʻi loa 12 mau hola.
Me nā ala hepatic, ua pale ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau. Inā hōʻike ʻia ka hina ʻole ma kahi palupalu, ʻaʻole pili kēia i ke kaʻina o ka hana o ka metabolites; i nā pilikia koʻikoʻi, ʻaʻole ka hoʻokaʻawale ʻia kā lākou hōʻiliʻili ʻana.
ʻO wai e hōʻike ʻia ʻo Glibenclamide
Ua kūkulu ʻia kahi hypoglycemic no nā maʻi maʻi me ka maʻi ʻelua. Ka kuhikuhi i nā lāʻau lapaʻau, ʻoiai ke hāʻawi nei i ka mea kanu haʻahaʻa-haʻahaʻa a me nā ukana mānoanoa maʻamau i hāʻawi i ka hopena i makemake ʻia.
Nā ʻala a me nā hoʻōla
Hoʻomaopopo ʻia ka Glibenclamide no ka hoʻohana koke ma hope o ka ʻaina. Hoʻopili ka endocrinologist i nā hopena ma muli o nā hopena o nā hoʻokolohua o ke koko no ka kō, ka makahiki o ka mea maʻi, ka nui o ka maʻi ma lalo o nā maʻi, nā kuʻuna concomitant a me ke olakino ākea.
I ka hoʻomaka mua o ka maʻi, ka maʻamau maʻamau ʻo 2.5-5 mg / lā. Lawe i ka lāʻau lapaʻau hoʻokahi manawa ma hope o ka ʻaina kakahiaka. Inā loaʻa ʻole ka uku piha no ka glycemia, hiki i ke kauka ke hoʻoponopono i ka nui ma o ka hoʻohui ʻana i ka 2.5 mg o ka lāʻau ma hope o hoʻokahi hebedoma. ʻO ka helu marginal (a hiki i 15 mg / lā) ka like me nā papa ʻekolu. Lele pinepine ʻia ka nui o ka aiau, a ʻaʻohe hopena nui o ka glycemia.
Inā loaʻa ka maʻi diabetes i ke kaumaha o ke kino e emi iho ma mua o 50 kg, ua kuhikuhi mua ʻia ke kaha lāʻau mua ma 2.5 mg, e pili ana i ka hapalua o ka papaʻaina. Inā ʻaʻole iʻoi aku ka maʻamau o kēlā me kēia lā i ʻelua mau ʻāpana, ke inu ʻona lākou i ke kakahiaka i ka kakahiaka kakahiaka, ma ka ʻaoʻao ʻē aʻe, ua hoʻohele ʻia ka lāʻau lapaʻau ʻelua, i ke kakahiaka a me ke ahiahi ma ka pāʻana o 2: 1.
Ke neʻe nei ʻo Glibenclamide ma hope o ka mālama ʻana i ka mālama ʻia me nā lāʻau lapaʻau hypoglycemic ʻē aʻe, e lilo ka ʻōmato hoʻomaka ma ka 2.5 mg hoʻokahi, i ke kakahiaka.
Me ka maikaʻiʻole, hiki iā ʻoe ke hoʻoponopono i ka maʻamau i kēlā me kēia pule ma ka hoʻohui ʻana i kahi 2.5 mg.
Ma ka hanana ʻana o ka hopena o ka mālama ʻana me nā lāʻau lapaʻau antidiabetic maikaʻi loa, ʻaʻole pono, e hoʻomaka ana ka helu hoʻomaka ʻana me 5 mg i ke kakahiaka, ma hope o ka papaʻaina. Inā loaʻa, kahi ʻae ʻia o ka 2.5-5 mg i kēlā me kēia pule. Ke mau nei ka palena palena i ka like - 15 mg / lā.
Inā ʻaʻole ka lāono o Glibenclamide i kēlā me kēia lā, aʻo ka nānā ʻana i kahi meaʻai haʻahaʻa-kāʻai a me ka hoʻoikaika kino kūlohelohe, ʻaʻole ia e hāʻawi i ka 100% o ka uku kōpala, hoʻoneʻe ʻia ka maʻi diabetes i kahi papa mālama lāʻau piha. Hoʻohui ʻia ka lāʻau nui me nā biguanides, insulin, a me nā mea ʻokoʻa hypoglycemic ʻē aʻe.
Inā hoʻopau ka ʻono endogenous i ka nui o ka insulin i ka maʻi maʻi maʻi me ka lua o nā maʻi e pani maoli ʻia i loko, ʻaʻole pono ka mālama ʻana i ka hopena like me ka monotherapy me ka hoʻomākaukau ʻana o ka insulin.
Inā no kekahi kumu i hala ka manawa e lawe ai iā Glibenclamide no hoʻokahi manawa a ʻelua paha mau makahiki, ʻaʻole hiki iā ʻoe ke lawe i ka lāʻau lapaʻau i ka wā e hiki mai ana. I ke kakahiaka aʻe, e lawe i kahi laʻa maʻamau, mai ʻōlelo i ka hoʻonui ʻana i ka helu.
Nā hopena hopena
Me kahi overdose o ka lāʻau, hiki i nā kūlana hypoglycemic o kēlā me ke ʻano o ka hōʻeha he nui, me ka coma. Me ka hoʻowahāwahā ʻia o ka waiʻona a i ʻole hoʻokahi a ʻelua paha i ka lā i ka lā, ma luna o ka hana, nā pilikia me ka ʻāʻā, nā kelepa thyroid a me nā ʻōpū, he hopena hiki ʻole nō hoʻi.
| Nā loea a me nā ʻōnaehana | Nā hopena hopena | ʻO nā pinepine o ka hōʻike |
| CNS | Ka hopena ʻana o ka ʻike loiloi manawa, paresthesia | I kekahi manawa |
| Kahe koko | ʻO Thrombocytopenia, erythrocytopenia, leukocytopenia, granulocytopenia, pancytopenia, vasculitis, anemia hemolytic | I nā hanana pinepine |
| ʻŌpala Gastrointestinal | ʻO ka maʻi Dyspeptic, hoʻololi i ka hoʻololi, hoʻopōʻino i ka mōʻī o ka neʻe i loko o ka ʻōpū, ka ʻeha o ka naʻau, aila o ka ʻōpū ʻana, cholestasis, jaundice | Ihiau |
| ʻŌnaehana papa maʻi | Hoʻololi kūlike | Pinepine |
| Allergies | Nā hopena Hyperergic, Lyell a me Stevens-Johnson syndromes, photosensitivity, erythroderma, exfoliative dermatitis, exanthema, urticaria | Ihiau |
| ʻO nā koho ʻē aʻe | Nā maʻi thyroid, lilo ka kaumaha | Hoʻohana wale me ka hoʻohana lōʻihi |
Nā Contraindications no ka hoʻohana ʻana o ka lāʻau lapaʻau
ʻAʻole i kuhikuhi ʻia kahi lāʻau lapaʻau no ka maʻi maʻi me nā maʻi maʻi mua, a me nā ʻano hana labile, ketoacidosis, coma, maʻi maʻi a me kona kūlana.
ʻAʻole hōʻike ʻia ka lāʻau lapaʻau no nā mea maʻi me nā pathologies o nā pūpū a me nā pōpoki, inā hoʻemi ʻia ka hana renal i nā waiwai cleince cleince ma lalo o 30 ml / min.
Inā he mea pākia a maʻi, hypersensitivity i ka diuretics thiazide a me sulfonamides, pono no hoʻi ke kauka ke noʻonoʻo i kēia mea.
I loko o ka manawa o nā maʻi hopohopo, ua hoʻohālikelike ʻia nā lāʻau lapaʻau ʻē aʻe, me ke ʻano lā o ka insulin, e uku i ka maʻi maʻi. Hōʻike ʻia ka maʻi Insulin no ka puhi nui, nā hōʻeha hōʻeha, a me nā hana koʻikoʻi, me ka hōʻili ʻia o ka pancreatic.
Me ka loaʻa ʻole o nā mea kanu, nā paresis o ka ʻōpū, ka pāpā ʻana i ke kakaka, ua contraindicated nā lāʻau lapaʻau.
Hoʻopaʻa ʻia ka Glibenclamine i ka wā o ka hāpai a me ka ʻōpū.
Nā hihia o ka Overdose o Glibenclamide
Hoʻohana ka lawelawe ʻōnaehana o ka māhele o ka overestimated o ka lāʻau lapaʻau i hoʻonāukiuki i ka hypoglycemia koʻikoʻi, kahi mea weliweli no ke ola o ka mea nāna.
Hiki ke loaʻa ka hopena like me ka hoʻohana ʻana i ka lāʻau lapaʻau e pili ana i ke kūmole o ke kīnā o ke ʻano kūʻai, ka hana ʻana o ke kino, ka mana o kekahi mau lāʻau lapaʻau i lawe pū ʻia me Glibenclamide.
Nā hōʻailona o kahi kūlana hypoglycemic:
- Ka pōloli make;
- Hoʻemi i ka maikaʻi o ka hiamoe;
- ʻŌpulopulu;
- ʻAeʻoki;
- Hoʻonui ʻia ka lulu ʻana;
- Ulo;
- Nā maʻi Dyspeptic;
- Hoʻolauleʻa;
- Hūlū lima;
- Tachycardia.
ʻO nā mea haehae i ka hana o ka psyche me nā pilikia endocrine hiki ke hōʻike ʻia i ke kaheʻe ʻana i ka ʻike, hopohopo, nā puʻupuʻu, nāwaliwali nāwaliwali, nānā ʻole ʻia, bifurcation of focus, panic inā ke kaʻa ʻana i ka kaʻa a mālama i nā mīkini pono, nā manaʻo kaumaha, ka huhū, nā pilikia o nā kīʻaha koko a me nā mea hanu, koma.
E kūlike aʻe ana i ke ʻano kaulike a me ka hoalohui o kahi overdose, hypoglycemia e hoʻohālikelike ʻia me ka hoʻohālikelike ʻia ʻana o nā derivatives sulfonylurea o ka hanauna mua.
No ka hōʻoluʻolu o ke ʻano o ka mea i hoʻopiʻi ʻia me kahi hōʻoluʻolu o ke ʻano o ka hoʻouka ʻana, hiki koke ʻoe iā ʻoe iho koke i nā kaola - ka momona, nā ʻāpana kīwī me ke kō a me ka wai momona (me ka mea aloha kūlohelohe). Inā ʻaʻole lawa kēia mau kaʻina, ua hoʻoili ʻia ka glucose (40%) a i ʻole Dextrose (5-10%) i loko o kahi uaua, a laila hopu ʻia ke kīmona (1 mg) i loko o nā ʻōpū. Hiki ke kiʻi ʻia ka Diazoxide. Inā ua lawe ka mea pepehi i ka acarbose, hiki ke hoʻoponopono ʻia i ka hypoglycemia waha ma ka glucose wale nō, akā ʻaʻole me ka oligosaccharides.
Inā ʻike ka mea pepehi i ka hypoglycemia, hoʻolaʻa ʻia ke kōpaʻa no ka hana o loko. I ka hihia o ka nalo ʻana, mālama ʻia ka glucose i ka iv, glucagon - iv, i / m a ma lalo o ka ʻili. Inā hoʻihoʻi ka naʻau, no ka pale ʻana i ka hoʻihoʻi, pono e hāʻawi ʻia kahi mea maʻi me kaʻai e pili ana i ka paʻakai wikiwiki.
Ka nānā kiaʻi ʻana i ka glycemia, pH, creatinine, electrolytes, urea nitrogen ka ʻike ʻia.
ʻO nā hiʻohiʻona o ka mālamaʻana me ka glibenclamide
- I ka wā e mālama ai me ka lāʻau lapaʻau, pono nā maʻi o ka maʻa i ke ʻano ikaika.
- I nā hihia no ke kīhaha o ke koko cerebral, ka maʻi, ka ʻona, hoʻolaʻa ʻia ka lāʻau lapaʻau me ka mālama.
- Pono ka maʻi maʻi maʻi e nānā mau i nā ʻāpana koʻikoʻi. Pono e hoʻopaʻa ʻia ka mika glucose ma kahi o ka liʻiliʻi (ʻelua) i hoʻokahi lā (ma ke ʻano, ua nānā ʻia ka ʻike glycemic 5 mau manawa / lā.). Pono ka nānāʻana o ka urine i kēlā me kēia lā no ke kahe ana o nā puna a me ke acetone.
- Me ka hemodialysis, nele i ka ʻai ma hope o ka lawe ʻana i ka lāʻau lapaʻau, kaumaha nui, ke kaumaha, ka ate a me ka pēpē o ka ʻōpū, ka inu ʻana i ka waiʻona, ka lawehala a me ka lawehala o adrenal, a me ka hui pū ʻana o kekahi mau kumu, ʻo ka ulu ʻana o ka ulu ʻana o ka maʻi glycemia koʻikoʻi. I ia mau kūlana, koi ʻia ka mālama mau ʻana i nā hōʻailona me ka hypomine e hoʻoponopono ʻia ke ana o ka lāʻau.
- Block-adrenoreceptor blockers, nā lāʻau lapaʻau e hoʻopilikia kino i ka ʻoihana sentral, hiki ke hoʻomohu i nā hōʻailona o ka hypoglycemia.
- I ka wā pākeke, ʻōlelo ʻia ka lāʻau lapaʻau ma kahi liʻiliʻi iki (mai ka 1 mg / lā), ʻoiai hiki ke loaʻa ka glycemia ma kēia pākuʻi no ka nāwaliwali o nā papa hana urinary.
- I nā hōʻailona mua o kahi alerine, hoʻopau ʻia ka lāʻau a hoʻonoho ʻia nā antihistamines. No ka wā lapaʻau holoʻokoʻa, pono nā pale o ka ʻokoʻa ultraviolet.
- Ma kahi o ka maʻi o ka maʻi, nā huaʻumau, nā mea ʻawaʻawa, ke hoʻomālamalama i ka maʻi o nā maʻi o ka maʻi (cholecystitis, pyelonephritis), hōʻeha ʻana i ka puʻuwai a me nā ʻano mea kino ʻē aʻe, ka maʻi NMC, gangrene, a me nā hana koʻikoʻi o ka maʻi maʻi, e hoʻohuli ʻia i ka insulin.
- Ma keʻano holoʻokoʻa, ʻaʻole i pili ʻo Glibenclamide i ka hoʻokele kaʻa, akā i nā kūlana kūlohelohe (e hana ana i nā kūlana paʻakikī, ʻehaʻeha, kiʻekiʻe, a me nā mea like), pono e mālama pono ʻia, no ka mea, ua hoʻoliʻoliʻu ʻia kahi ʻano hoʻololi i nā puna koko i nā manawa a pau.
- Pono e mālama pono i ka mālama ʻana i nā lāʻau lapaʻau, ke koho ʻana i ka nui o ke ʻano kūpono, a me ka hoʻohana ʻole ʻia ʻana o nā lāʻau lapaʻau.
ʻO nā mea hoʻohālikelike Glibenclamide
I kulike ai me ka code ATX o ka pae 4 i ka lāʻau lapaʻau Glibenclamide match:
- Kūkulu;
- Amix;
- Amaryl;
- Gliclazide;
- Maninil;
- ʻO Glidiab;
- Glimepiride;
- Diabeton.
E like me nā hōʻailona o nā hōʻailona like ʻole, pili ʻo Glibenclamide i nā lāʻau lapaʻau Glibex, Gilemal, Glibamide, Glidanil.
ʻO nā hopena Hoʻohui Pāleʻa ʻo Glibenclamide
Hoʻololi ka hoʻopuka ʻia ʻana o ka glimenclamide, ʻoiai e hoʻonui ana i kona mana hypoglycemic, azopropanone, miconazole, hoʻomākaukau i ka waikawa Coumaric, oxyphenbutazone, sulfonamide hui lāʻau, phenylbutazone, sulfapyrazonfeniramidol.
ʻO ka hui pū ʻana me nā lāʻau lapaʻau e hoʻohiolo ana i ke kō, e hoʻoneʻe ana i ka pale ʻana i ka insulin, e hōʻike ana i nā hopena like.
Me ka hoʻoneʻe pili o ka lāʻau anabolic, allopurinol, cimetidine, β-adrenergic receptor blockers, cyclophosphamide, guanethidine, clofibric acid, monoamine oxidase inhibitors, sulfonamides me ka hana lōʻihi, salicylates, tetracyclines, inu wai, ka hypoglycemic potopapa o ka hiki ke hoʻomau pono
Inā barbiturates, chlorpromazine, rifampicin, diazoxide, epinephrine, acetazolamide, nā lāʻau hoʻonaʻina simpathomimetic, glucocorticosteroids, glucagon, indomethacin, diuretics, komo acetazolamide, nicotinates (ma nā nui) , ʻona saluretics, nā paʻakai lithium, nui nā wai inu a me ka laxative, ua hoʻemi ʻia ka hopena o ka glimenclamide.
Hōʻike ʻia nā hopena he kumu ʻole o ka launa pū me ka hoʻohana pākuʻi e nā H2 receptor antagonist.
Nā Hōʻike Manaʻo Glibenclamide
Ma nā papa kūkala, ʻoi aku ka maʻi maʻamau a me nā kauka e kūkākūkā i nā mea e pili ana i nā hoʻoponopono lāʻau lapaʻau like ʻole. E hoʻopiʻi ka poʻe i kuhikuhi i ka monotherapy ma ke ʻano he lāʻau lapaʻau i ka loaʻa ʻana o ka uku kōnī piha. Me ka hoʻomaʻamaʻa paʻakikī, ʻike kekahi i nā hana Glibenclamide nui loa.
Hoʻomaopopo nā kauka i ke koho ʻana i nā kao kūpono loa no Glibenclamide, e hiki iā ʻoe ke mālama i ke ola maʻamau no ka manawa lōʻihi, pono ia i kahi ala pilikino, pono i ka manawa a me ka mālama mau ʻana i ka heluhelu ʻana o ka glucose moka no nā kūlana like o ka mea maʻi. I ia mau hanana, ʻaʻole hiki ke hoʻopili wale ʻia nā ʻōlelo aʻo ʻana, akā he mea weliweli nō hoʻi.
ʻO ka ʻike e pili ana i ka lāʻau lapaʻau ma ka pūnaewele no ka hoʻopili a me ka hoʻonui ʻana, i hōʻiliʻili ʻia mai nā wahi i loaʻa a ʻaʻole ia ke kumu no ka maʻi a me nā lāʻau lapaʻau ponoʻī. ʻAʻole ia e kahuli i ka ʻōlelo aʻo a ka mea he endocrinologist.
