ʻO ka Glidiab kahi lāʻau lapaʻau antidiabetic nona nā manaʻo e alakaʻi i ka mālamaʻana i ka maʻi diabetes mellitus type 2: e hoʻihoʻi ana i ka mana glycemic, kāpae i nā glucosuria (hoʻonui i ka glucose o ka glucose i nā hōʻike urine).
ʻO ka hiʻohiʻona o ka lāʻau lapaʻau
I loko o kahi pūnaewele lapaʻau ʻo Glidiab (ma ke ʻano honua - Glidiab) hiki ke kūʻai ʻia i loko o ka ʻano o nā papa no ka hoʻohana waha. Hāʻawi kahi mea hana pono hoʻokahi a me nā ʻenehana hou no ka mālama ʻana i ka helu o ka hoʻokuʻu ʻana o ka mea hana. He multivariate ke kala o ka uhi ʻana: keʻokeʻo, ʻeleʻele, kaʻaila.
Ma kahi kuhi i loko o nā pūnaehana contour, 10 nā paona he paona ʻia he 80 mg a paʻa me ka gliclazide. Hoʻohui ʻia me nā mea hoʻohui o hoʻohui ʻia: ke kō, ka mana o ka magnesium, ka sodium starch glycolate, ka waiū honi, hypromellose, MCC, talc.
1 papa o ka lāʻau lapaʻau Glidiab MV he 30 mg o gliclazide. Hoʻohui ʻia ia e MCC, hypromellose, magnesium stearate, aerosil.
Hiki i nā pono Pharmacological
ʻAʻole e like me ka laina o ka mua o nā lāʻau lapaʻau, ʻo Glidiab ka mea maʻalahi a me ka maikaʻi loa, a ʻo kā ona hypoglycemic pili i ka mea i lalo o ka mana o Glidiab:
- Hoʻonui ka hana insulin e nā β-cell;
- Hoʻohana ʻia ka hana o ka glycogen hepatic;
- Hoʻopili nā mea hoʻolimalima i nā gluconeogenesis;
- Hoʻohui ʻia ka hana insulin Endogenous;
- Hoʻopiliʻia ke kāpiliʻana o ka glucose mai nā protein a me nā momona i ka ate;
- Hoʻopilikia hou ka naʻau a me nā ʻōpū a me ke au i nā glucose;
- Hoʻoweliweli ka lipolysis i loko o nā lau.
E pili ana iā Glidiab, ua hōʻoia ʻia nā loiloi o nā kauka e like me ka hoʻohana ʻana i nā lāʻau lapaʻau, hoʻemi ka hōʻemi ʻana i ka insulin o nā ʻiʻo peripheral, hoʻoneʻe nui o nā ʻoli, nā mea kikoʻī o ka glycogen synthetase, hoʻāla iki ka wā ma waena o ka meaʻai a me ka insuline.
Hoʻohālikelike ʻia i nā lāʻau lapaʻau ʻē aʻe o ka hui sulfonylurea (glibenclamide, chlorpropamide), ka mea e hana nui nei ma ka lua o ke kani ʻana o ka synthesis hormone, kōkua ʻo glycoslide e hoʻihoʻi hou i ka nui o ka nui o ka hoonui o ka insulin a hōʻemi ʻana i ka glycemia koʻikoʻi. Hoʻopili i nā hoʻomaʻamaʻa kaʻina metabola, hoʻomaikaʻi ka lāʻau lapaʻau i ke kahe koko o ka capillary, hoʻēmi i ka piʻi platelet a me ka hōʻuluʻulu ʻana, ma laila e pani ai i ka hana o nā pākī.
E like me nā kuhikuhi, gliclazide:
- E hoʻomaikaʻi i ka vascular pagkamatima a me ka elasticity;
- Hoʻohana e pale ai i ka microthrombosis;
- Hoʻopili ia i ka ʻike ʻana o nā paia vascular i adrenaline;
- Hoʻoponopono i nā fibrinolysis physiological (hoʻomaʻemaʻe mai nā clots koko);
- Hoʻēmi i nā ʻike o ka kolamu holoʻokoʻa, he hopena anti-atherogenic (pale a me ke regression o ka atherosclerosis);
- Hoʻokuʻu nei i ka holomua o retinopathy ma ke kahua mua-proliferative.
ʻO ka hoʻohana pinepine ʻana o Glidiab e ka maʻi maʻi maʻi me ka nephropathy e hoʻomaikaʻi koʻikoʻi i ka neʻe o ka protein i ka urine. ʻAʻole kōkua ka lāʻau lapaʻau i ka loaʻa kālā, ʻoiai ʻo kāna hana nui i ka hana mua loa o ka insulin, ʻaʻole ia e hoʻonāukiuki i ka hyperinsulinemia. Hiki i ka lāʻau lapaʻau ke mālama i ka maʻi hānai i ka nui o ke kaumaha, e pae ana i ka loli ʻana o ke ʻano.
ʻO ka Pharmacokinetics o ka lāʻau
Ke kiʻekiʻe o ke kīhaha o ka gliclazide i ka gastrointestinal tract ma hope o ka lawelawe ʻana o ka waha o ka lāʻau ke kiʻekiʻe. ʻO ka lawe ʻana i hoʻokahi mahele o ka lāʻau lapaʻau (80 mg) hoʻolako i ka pae o ka nui o ka hana ma ka plasma koko ma hope o 4 mau hola. ʻO nā metabolites i loko o ka palaleka nā mea biotransformed: ka maʻi oxidation, hydroxylation a me ka glucuronidation alakaʻi i ka hoʻokumuʻana o 8 metabolites kahi kūleʻa e pili ana i ka glucose. Hiki i kekahi o nā metabolites ke hoʻopilikia i ka microcirculation. Hoʻopili ʻia nā huahana hōʻala e nā keiki (70%) a me nā ʻāpana (12%). I kāna hana kumu, hoʻopuka wale ʻia 1% o Glidiab. Hoʻopau ka hapalua hapalua-ola ma ka waena o 8-11 hola.
ʻO Glidiab i ʻōlelo ʻia
ʻO Glidiab e like me nā ʻōlelo kikoʻī no ka hoʻohana ʻana ua noi ʻia no nā maʻi maʻi maʻi me ka maʻi type 2 o ke ʻano hōʻeha, i ka wā e hoʻomohala ana nā ʻōhua e like me ka microangiopathy. ʻAe ʻia e hoʻohana i ka lāʻau lapaʻau no ka monotherapy a i ka hoʻōla paʻakikī ʻana, me nā lāʻau lapaʻau hypoglycemic ʻē aʻe. Noi ʻia ʻo Glidiab me nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka maʻi hemorheological o ka maʻi maʻi.
I kēlā me kēia kūlana, ke kuhikuhi ʻia nei ka lāʻau lapaʻau me ka lawa ʻole o ka lāʻau lapaʻau ʻana a i ʻole e hoʻohui i ka loli ʻano o ke ola.
Hoʻopilikia ka pōʻino mai ka gliclazide
ʻO ka lāʻau lapaʻau Glyclazide e hoʻohālikelike ʻia:
Maʻa maʻi maʻi me nā maʻi ʻano ʻehā;- Me ka hoʻolālā ʻana o ka labile o ka maʻi maʻamau 2;
- Me ka ketoacidosis;
- ʻO nā maʻi me ka insuloma;
- I nā kūlana e hoʻonāukiuki ai i ka maʻi ma mua a me ke ahulau;
- ʻO nā poʻe me ka pūliki a me ka maʻi hepatic;
- Me ka microangiopathy koʻikoʻi;
- Diabetes me ka hypersensitivity i sulfonylureas;
- I ka wā o nā maʻi hopohopo;
- I ka wā hāpai a me ka lactation;
- I ke kamaliʻi (ʻaʻohe ʻikepili e pili ana i nā pono a me ka palekana);
- 48 mau hola ma mua a ma hope o ka hoʻouka nui.
Maʻa maʻi maʻi me nā maʻi ʻano ʻehā;Pehea e hoʻopili ai i ka lāʻau lapaʻau
Ma mua o ke kau ʻana i kahi regimen lapaʻau, loiloi ke kauka i ke ʻano maʻamau o ka mea maʻi, ka makahiki, ka ʻano o ka maʻi, a me nā hoʻopiʻi e pili ana. Hoʻokumu i ka hōʻailona o ka wikiwiki a me ka glycemia postprandial, me ka paʻa o nā lāʻau antidiabetic e lawe like ʻole ʻia ka mea maʻi, e helu ʻia ka helu o kēlā me kēia lā ʻo Glidiab. Ua noʻonoʻo pū ʻia ka hopena o ke kanaka maʻi i ka lāʻau lapaʻau.
No ka lāʻau lapaʻau maʻamau
No Glidiab maʻalahi, nā ʻōlelo e hoʻohana ai no ka hoʻohana ʻana i kahi maʻi maʻamau o ka lāʻau - 80 mg / lā., Kaʻaina - 160 mg, loa - 320 mg. Hoʻohana pālua: i ke kakahiaka a me ke ahiahi, 1 papa ma mua o ka papaʻaina. I nā ala no nā renal, inā he hōʻemi loa ka mīkini ma lalo o 15 mau pūʻulu, ʻaʻole pono ke hoʻoponopono ʻia.
No ka mea i ka mana ʻo Glidiab MV
I ka maʻi maʻi (me ka māhele gerontological), ʻo ke ʻano maʻamau o ka lāʻau me ka hopena lōʻihi ma ka papa hoʻomaka ʻana he 30 mg. Hiki ke hoʻoponopono ma ke ʻano maʻamau ma hope o 14 mau lā. ʻO ka palena loa o Glidiab MV, e like me nā ʻōlelo no ka hoʻohana ʻana, ʻo 120 mg / lā kēia e pili ana i nā 4 pcs. ʻO nā pōpō. Lawe ʻia ka lāʻau lāʻau me ke kakahiaka. Hāʻawi ia e lawe i nā lawepiko a hypoglycemic like: biguanides, α-glucosidase enzyme inhibitors, insulin.
Nā hopena hopena
E pili ana i nā loiloi Glidiab e hōʻike nei i kekahi mau mea, hoʻopili ʻia ka mālama ʻana me nā mea e ʻike ʻole.
ʻO ka maʻi diomaʻi luhi o ka luhi, dizziness, hōʻeha, kaomi, pancytopenia, allergies, pruritus, photosensitization, dyspeptic disorders, asthenia, epigastric discomfort, sensation impaired, ʻeha.
Hoʻomaʻamaʻa iki a maʻamau ka hypoglycemia, paresis, thrombocytopenia, leukopenia, agranclocytosis, anemia. I ka nui o nā mea, hoʻohuli ʻia nā hopena āpau: ma hope o ka hoʻokuʻu ʻana o ka lāʻau lapaʻau, nalo lākou i luna.
Ke pale i ka hypoglycemia a me nā hopena ʻē aʻe i makemake ʻia, he mea koʻikoʻi ke kuhikuhi i ka hoʻohana ʻana i nā papa no ka komo ʻana i ka meaʻai, ke pale aku i ka pōloli a me ka hoʻopau ʻana i ka waiʻona mai ka meaʻai.
Nā hopena lāʻau lapaʻau me Glidiab
| ʻAoa inoa o nā lāʻau lapaʻau | Hua hopena |
| ʻO nā lāʻau lapaʻau Ethanol | ʻO ka hypoglycemia, hypoglycemic coma ma muli o ka kaomi ʻana o nā hana uku e ka waiʻona. |
| ʻO Miconazole | Nā kūlana he hypoglycemic (a me ke coma). Lāpule papaʻa! |
| Block-adrenergic blockers | Nā hōʻailona hōʻailona e hoʻokūkū ana i ka hypoglycemia. |
| Sulfonamides | Ke hoʻonui nei ka hopena o ke kōpaʻa haʻahaʻa o gliclazide. |
| Hoʻomoʻa ʻia ʻo Salicylic Acid | Hoʻonui i nā mana o Glidiab. |
| MAO ka mea paʻa | Hoʻohui ʻia nā ʻano anti-diabetes. |
| Theophylline | Hoʻonui lākou i nā waiwai o ka hypoglycemic o ka lāʻau. |
| Salbutamol | Hoʻonui nā poʻi glucose. |
| Nā Pūlani | Hōʻike i ka hana o Glidiab. |
| ʻO nā huahana e loaʻa i ka Estrogen | ʻO ka pale nui o ka maʻiemia. |
| Terbutaline | ʻO ka ulu o nā huakiko o ka glucose. |
| Fluconazole | Ka hopena o ka hypoglycemia. |
| Kāleka | Hoʻonui i nā helu naʻau hypoglycemic. |
| Hoʻokomo Tetracosactide | ʻO ka pōʻino o ka uluʻana i ka ketoacidosis. |
| Hoʻolālā | Hoʻopili i ka Glidiab hypoglycemic catald. |
| ʻO kou kumupaʻa thyroid | Hōʻike i nā pono o nā lāʻau lapaʻau. |
| ʻO nā lāʻau lapaʻau pili Lithium | Hoʻopili i nā hiʻohiʻona hypoglycemic. |
| ACE paleai | E hoʻolōʻihi i ka hopena hypoglycemic. |
| Diuretics | ʻO ka paleʻana o ka laweʻana i ka glucose. |
| ʻO Cimetidine | ʻO ke Kumuhana Hula |
| Progestins | Hawaemia. |
| Hoʻolaha ʻia nā kukuna | ʻO ka Hyperglycemia. |
| Nā māhoe male | Ke hoʻoikaika nei i nā paʻi o ka glucose. |
| Nā huaʻōlelo ʻo progestogens | ʻO ka uluʻana o nā hōʻailona kuhikuhi. |
| Nā NSAID | Hawaemia. |
| Ritodrin | ʻO ka paʻakikī o ka hyperglycemia. |
| Sulfonamides | ʻO ka hopena o nā kūlana hypoglycemic. |
| Fenfluramine | Hoʻolauna ʻo Glyclazide Health. |
| Feniramidol | Hoʻonui ka hopena hypoglycemic. |
| Hoʻopuka ʻana | Hoʻonui i ka pono o ka lāʻau lapaʻau. |
| Chloramphenicol | ʻO ke kākuhi no nā mākau o ka lāʻau lapaʻau. |
| Kāleka hua'ōlelo Cardiac | Aia kahi hoʻohālikelike o ka ventricular extrasystole. |
Ke keu
Me ka hoʻonui nui o ka maʻa ma mua o ka therapeutic, aia kahi i ka emi nui o ka hōʻemi o nā maʻi glycemic. Hiki i ka overdose kūpilikiʻi ke hoʻopili i ka hoʻomohala ʻana i ka comly glycemic. Inā maopopo ka mea make a make i ka paila, hāʻawi ʻia ʻo ia i ka sucrose, dextrose, kūlohelohe a i ʻole nā mea momona wale nō (me ka mea ʻole nā mea momona make).
I ka mea hoʻomanawanui ʻole, ʻike ʻia nā lāʻau lapaʻau ma ka intravenously (40% dextrose) a i ʻole intramuscularly (1-2 g o glucagon). Ma hope o ka hāpai hou ʻana, pono ka pānaʻi e hāʻawi wikiwiki i ka nui o ka mauʻu i mea e pale ai i ka hoʻi hou ʻana.
Pākuʻi helu
Hiki ke kūʻai aku i ka lāʻau lapaʻau ma ke ʻano lāʻau lapaʻau i loko o nā pepa. Hana ʻia i nā ʻano ʻelua: ʻo Glidiab maʻamau (6 mau papa o nā 10 pcs. ʻO kēlā me kēia pā) a me Glidiab MV, i kā ka ala hou ʻia o ka waiwai ikaika (3 a i ʻole nā papa 6 o 10 mau pika. Ma kēlā me kēia pahu).
Ma kahi kumukūʻai maʻalahi loa ʻo Glidiab e kūpono loa - 106-136 rubles. no nā papa 60 o 80 mg. Ma Glidiab MV, he kiʻekiʻe loa ke kumukūʻai ma nā lāʻau lapaʻau ma ka pūnaewele: 160-166 rubles. no nā papa 60 o 30 mg.
Nā kānāwai mālama
ʻAʻole koi ʻo Glidiab i nā kūlana kūikawā. Pono e hoʻonoho ʻia ka pahu kōkua mua ma kahi kumu o ka ea, ke kūlohelohe a me ka maʻa o ka ultraviolet a me ka nānā ʻana o nā keiki, nā holoholona a me nā mea maʻi kino. He kūlana wela - a hiki i 25 ° С. Hoʻohana ʻia nā papa i loko o ka lā lohi: 4 mau makahiki no ka lāʻau lapaʻau Glidiab a me 1 makahiki no kāna hoʻololi ʻia o Glidiab MV. I ka pau ʻana o ka lā kau i hoʻonohonoho ʻia e ka mea hana, pono e hoʻokuʻu ʻia i ka lāʻau lapaʻau, no ka mea e hoʻemi ʻia kona pono, a ke ulu nei ka nui o nā hopena kūpono.
ʻO nā mea like a me nā mea kikoʻī o Glidiab
ʻO ka lāʻau lapaʻau mua loa ʻo Gliclazide me ka waihona like ʻole, nā mea āpau o ke koea. ʻO Glidiab i ka papa inoa i manaʻo ʻia e ʻoi loa ka maikaʻi. E like me ka mea hana (gliclazide) a me ka hui (mau mākaʻi antidiabetic waha), nā hui me Glidiab e like like: Gliclazide, Diagnizid, Diatika, Diabinax, Diabefarm, Diabresid, Diabetalong, Glioral, Predian, Gliclada, Glucostabil, Diabeton, Diablored, Panmicron, Gluktam, Glisid, Medoklazid.
I waena o nā meaʻala e like ai ka koho (like me ka diabetes type 2) ka mea i kaulana loa: Lymphomyozot, Januvia, Multisorb, Bagomet, Glemaz, Metamin, Baeta, Apidra, Glyurenorm, Formmetin, Glyukobay, Novoformin, Levemir Flekspen, Formin, Levemir Penfill, Avandia, Pioglar.
Nā ʻōlelo ʻokoʻa
E hoʻohaʻahaʻa loa ka hopena o ka mālama ʻana me Glidiab me ka ʻole o ka hoʻololi ʻana i ke ʻano o ke ʻano maʻi diabetes: nā haʻahaʻa haʻahaʻa haʻahaʻa, ka nui o ka hoʻoikaika kino, ʻohi ʻana o ke kūlana psychoemotional, adherence e hiamoe a hoʻomaha.
He mea nui ia e kiaʻi pono i kā kou glycemic profile ma ka nānā ʻana i ke kiʻekiʻe o nā honi ma ka home a ma ka pūʻai ʻana.
Me ka glucometer, e mālama mau ana ka glycemia i ka ʻōpū ʻole i ke kakahiaka, 2 mau hola ma hope o ka ʻaina a ma mua o ka hiamoe ʻana, i ke ahiahi.
ʻO ka diabetics e loaʻa ana i ka hui pū ʻia me nā hoʻomākaukau insulin e pono e kiaʻi i ka haku koko ma mua o kēlā me kēia kaha o ka puhi o ka hormone. He mea nui ia e mālama i nā hana o ka hoʻololi i nā hōʻailona i loko o ke ao, a me ka nānā ʻana i nā heluhelu heluhelu maʻamau i loko o ka mahina - mai ka kūkākūkā ʻana o ka endocrinologist a me ka hālāwai aʻe.
Hiki i ka lāʻau lapaʻau ke hopena maikaʻi i nā hopena psychomotor. Hiki i kēia ke hana i nā pilikia i ka wā e hoʻokele ai, ka hoʻokele ʻana i nā mīkini paʻakikī, hana ma nā wahi kiʻekiʻe a me nā hana ʻē aʻe e pono ai ke koi ʻia.
Inā hōʻike ʻia ʻo Glidiab i kahi makuahine hānai, hiki ke hoʻohana ʻia ma hope o ka hoʻoneʻe ʻana i ka pēpē i ka ʻai hānai.
