ʻO ka hopena no ka maʻi type 2 ke komo nei i ka hoʻokele ʻana o nā lāʻau lapaʻau hypoglycemic o nā hui like ʻole.
ʻO ka pili kēia o nā derivatives sulfonylurea.
ʻO kekahi o nā ʻelele o kēia hui he chlorpopamide.
ʻO ka ʻike nui o ka lāʻau lapaʻau
ʻO Chlorpropamide kahi mea ikaika e pili ana i ka 1st 1st sulfonylurea derivatives. ʻO kāna hui pharmacological a me nā mīkini synthetic hypoglycemic synthetic. ʻAʻole hoʻoheheʻe ʻia ʻo Chlorpropamide i ka wai, akā, ma kahi ʻē aʻe, hoʻomāliʻi i ka inu wai.
ʻAʻole e like me nā hanauna ʻē aʻe o ka derivatives o ka olonylurea, e hana pōkole ana ʻo chlorpropamide. E hoʻokō i ka pae kiʻekiʻe o ka glycemia, hoʻohana ʻia ma nā ʻano nui.
Hoʻomaopopo loa nā hopena ʻaoʻao o ka lawe ʻana i ka lāʻau i hoʻohālikelike ʻia me Glibenclamide a me nā luna ʻē aʻe o ka hanauna 2. Maʻaola me ka lawa ʻole o ka hana ʻana o ka hormone (insulin) a me kahi laʻa o ka hoʻēmi i nā aihue. Loaʻa ka hopena me ka chlorpropamide i nā mea maʻi me ka mahele maʻi diabetes indipidus a me / a me ke ʻano maʻi diabetes paha 2.
ʻO Chlorpropamide ka inoa generic inoa no kahi lāʻau lapaʻau. ʻO ia ke kumu o ka lāʻau lapaʻau (he ʻano ikaika). Loaʻa i nā papa.
Ka hana lāʻau lapaʻau
Loaʻa ka lāʻau lapaʻau i ka hopena hypoglycemic. Hoʻopili ka mea i nā pāhare pālala, hoʻoulu i ka mea huna o ka insulin. I loko o nā kiko a me nā huelo e hoʻoulu ʻia e ka insulin, ka nui o nā mea i hōʻemi no ka hormone hoʻonui.
Ma ke alo o ka insulin endogenous, hoʻemi ka nui o ka glucose. He hana antidiuretic. Ma muli o ka hana huna ʻana i ka insulin, loaʻa ka loaʻa o ka paona.
ʻO ka hoʻomaha ʻana i ka glycemia he liʻiliʻi i ka honi koko. ʻO Chlorpropamide, e like me nā sulfonylureas ʻē aʻe, e lawe ana i nā pilikia o ka hypoglycemia, akā i ka liʻiliʻi.
Ke hui pū ʻia me nā ʻaina hypoglycemic ʻē aʻe (biguanides, thiazolidinediones, ʻike i ka launa pū me nā lāʻau lapaʻau ʻē aʻe), ua hoʻemi iki ʻia ka dosage o ka hopena.
Ka hana o ka hana o nā derivatives sulfonylurea
Lapaʻau lāʻau
Ma hope o ke komo ʻana i ka hana kūwili, hoʻopili maikaʻi ʻia ka chlorpropamide. Ma hope o hoʻokahi hola, aia ka waiwai i loko o ke koko, ʻo kona mau kikoʻī loa - ma hope o nā hola 2-4. Hoʻomili ʻia ka waiwai i ka puʻu. Hoʻolaha ka protein protein> 90%.
Ke hana nei ka lāʻau lapaʻau i ke ao holoʻokoʻa i ka hihia. ʻO ka pauʻana o ka hapalua-ola he 36 mau hola. Hoʻokuʻu ʻia ia ma ka urine (a ʻo 90%).
Nā hōʻailona a me nā contraindications
ʻO nā ʻōmina no ka hoʻohana ʻana nā non-non-insulin-dependant, a me ka maʻi insipidus maʻi. Ua hoʻonohonoho ʻia ʻo Chlorpropamide i nā hihia kahi i mālama ʻia ai ka mālama ʻana i ka meaʻai, ʻaʻole lawe mai nā lāʻau lapaʻau i ka hopena kūpono i ke hoʻoponopono ʻana i nā hōʻailona.
I waena o nā contraindications i ka hoʻohana ʻana o ka lāʻau lapaʻau ka mea:
- hypersensitivity i ka chlorpropamide;
- ʻAno maʻi type 1;
- hypersensitivity i kekahi sulfonylureas;
- ka hana 'ana me ka hopena pili i ka acidosis;
- lipology thyroid;
- ketoacidosis;
- akeū a me nā hana ʻole;
- maʻi maʻi pāpaʻi;
- hapai / lactation;
- kupuna a coma;
- makahiki o na keiki;
- ka hana pinepine ʻana o ka hana chlorpropamide;
- mau kūlana ma hope o ka haʻalele ʻana o ka pancreatic.
ʻLoe a me ke kākele
Hoʻonohonoho ʻia ka lāʻau lapaʻau e pili ana i ke papa o ka maʻi maʻi a me ka hoʻomaha ʻana o ka glycemia. I ka loaʻaʻana o ka uku kūpono ma ka maʻi maʻi, hiki ke hoʻemi ʻia. Ma ke ʻano he kānāwai, me ka maʻi maʻamau o ka lā 2, ʻo ke ʻano o kēlā me kēia lā he 250-500 mg. Me ka maʻi maʻi maʻi indipidus - 125 mg i kēlā me kēia lā. Ke hoʻoili ʻia i nā lāʻau ʻē aʻe, e pono ai ke hoʻoponopono ʻia ʻana.
Hōʻike nā ʻōlelo no ka hoʻohana ʻana i ka chlorpropamide i ka hoʻohana ʻana i ka lāʻau i ka hapalua hola i mua o ka papaʻaina. Pono ia e hoʻopau iā ia i ka manawa hoʻokahi. Inā hāʻawi ka dosage i ka liʻiliʻi o nā papa ʻelua, a laila e loaʻa ka hoʻokipa i kakahiaka.
ʻO nā wikiō mai kahi loea e pili ana i ka maʻi diabetes a pehea e mālama ai iā ia:
Nā hopena ʻaoʻao a me ka overdose
Hiki i nā hopena ʻokoʻa ke hopena i ka wā o ka hoʻokele ʻana o ka chlorpropamide:
- holo, ka luaʻi, ʻeha ʻeha, huhū;
- hypoglycemia;
- hyponatremia;
- ka ʻaha ʻili o ka waha, nele o ka momona;
- ʻike ʻole i ka nānā;
- ʻili pehu o kekahi ʻano ʻē aʻe;
- hemolytic anemia;
- hoʻonui i nā ʻōkuhi ate;
- thrombo-, leuko-, erythro-, granulocytopenia;
- hōʻeha a me ka ʻeha;
- ka hoʻemi ʻana o ke kaomi;
- nāwaliwali, palaleka, nā hiamoe, hopohopo;
- jaundice kikestice;
- ka mālama kaʻa ʻana i ke kino;
- anaphylactic pīhoihoi.
Me ka lewa maʻalahi / maʻalahi o ka hypoglycemia, lawe ka mea maʻi i ka 20-30 kāpela o ka glucose. I ka wā e hiki mai ana, ua hoʻoponopono ʻia ke kūpono a hoʻoponopono hou ʻia ka meaʻai.
I nā pilikia koʻikoʻi, e hele pū me ka coma a me nā mea hoʻokūkū, e lawelawe ʻia ka glucose i ka intravenously. Eia kekahi, ke lawelawe ʻia paha o glucagon a intramuscularly paha. Ma hope o ka hoʻopaʻa ʻana i ka hypoglycemia i loko o ʻelua mau lā, ua nānā ʻia nā hōʻailona e hoʻohana ana i kahi glucometer.
Nā hiʻohiʻona noi
Ma mua o ka hoʻolālā ʻana i ka wā hapai, pono ʻoe e haʻalele i ka chlorpropamide. Manaʻo ʻia ka maʻi diabetes type 2 me ka insulin e manaʻo ʻia e ke ʻano maikaʻi loa. I ka wā lactation, pili lākou i nā loina like.
Hoʻololi ʻia i ka lāʻau lapaʻau mai ka hapalua i kahi papa i kēlā me kēia lā, a laila e kuhikuhi ʻia no ka papa mua. ʻO nā mea maʻi me ka hana renal maʻi hepatic e pono ai he hoʻoponopono hoʻoponopono ʻia. I ka helu ʻana i ka papa o ka lāʻau lapaʻau i nā poʻe kahiko, ua noʻonoʻo ko lākou makahiki.
Ke koi nei ʻo ia no ka maʻi, pono ke hoʻemi ʻia ʻana ma ke ʻano. Lawe ʻia ka hoʻoponopono ʻana me nā loli i ke kaumaha o ke kino, ke kaumaha, ka neʻe ʻana i kekahi pae manawa hou.
Ma muli o ka nele o nā ʻike e pili ana i ka palekana o ka hoʻohana, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau i nā keiki. I ka hihia o nā hōʻeha, ma mua / ma hope o ka hana, i ka manawa o nā maʻi maʻi hopohopo, e hoʻokaʻawale ʻia ka mea maʻi i ka insulin.
Mai hoʻohana me Bozetan. Aia ma laila he hōʻike no ka hopena maikaʻi loa i nā maʻi i loaʻa i ka chlorpropamide. Kuhi lākou i ka hoʻonui ʻana i nā maʻi hepatic (enzymes). E like me nā waiwai o nā lāʻau ʻelua, ua hōʻemi ʻia ka ʻano o ka hoʻōla ʻana o nā waikawa bile mai nā papa Hoʻopili kēia i kā lākou hōʻiliʻili, nāna e hele i ka hopena o kahi meaʻala.
Hoʻopili me nā lāʻau lapaʻau ʻē aʻe
ʻO Biguanide Metformin
Me ka hana like o ka chlorpropamide a me nā lāʻau lapaʻau ʻē aʻe, e hoʻēmi paha ka hopena a hoʻonui paha. Kūloko paʻa i mua o ka lawe ʻana i nā lāʻau lapaʻau ʻē aʻe.
Ulu lāʻau 'ana ia lŘlŘ ka wā coadministered me insulina, nā hypoglycemic ai', biguanides, coumarin nā mea loaʻa, phenylbutazone, ai 'tetracycline, Mao nā mea kūpale, fibrates, salicylates, miconazole, streroidami, kane hormones, cytostatics, sulfonamides, quinolone nā mea loaʻa, clofibrate, sulfinpyrazone.
ʻO kēia mau lāʻau lapaʻau e hoʻonāwaliwali i ka hopena o ka chlorpropamide: barbiturates, diuretics, adrenostimulants, estrogens, contraceptives tableted, nui i nā kūmole nui o ka acid nicotinic, diazoxide, hormon thyroid, phenytoin, glucocorticosteroids, sympathomimetics, deretazolamide.
ʻO Chlorpropamide kahi aikoi hypoglycemic e pili ana i ka 1st 1st sulfonylurea derivatives. Ke hoʻohālikelike ʻia me kāna poʻe hahai, he haʻahaʻa hoʻohaʻahaʻa ia o ka hoʻohaʻahaʻa a me nā hopena hou aʻe. I kēia manawa, ʻaʻole hana ka lāʻau lapaʻau.
