ʻO Atorvastatin-Teva kahi lāʻau lapaʻau hypolipidemic. ʻO ka hana o ka hana o ka lipid-hoʻemi haʻahaʻa i ka hoʻemi ʻana i ka pae o ka "bad" kolesterol, a me ka nui o ka triglycerides a me lipoproteins o ka haʻahaʻa haʻahaʻa a haʻahaʻa. I ka huli, e hoʻonui lākou i ka ʻike o ka lipoproteins density kiʻekiʻe a me ke kolamu "maikaʻi" maikaʻi.
Loaʻa Atorvastatin-Teva i ke ʻano o nā papa ʻulaʻula keʻokeʻo. Ua kahakaha ʻia ʻelua mau palapala i ko lākou alo, ʻo kekahi o lākou ʻo “93”, a ʻo ka lua e hilinaʻi ʻia ma ka helu o ka lāʻau. Ina he dosis ka 10 mg, laila ua kahakaha ʻia ka palapala "7310", inā 20 mg, a laila "7311", inā 30 mg, a laila "7312", a inā 40 mg, a laila "7313".
ʻO ka papa hana nui o Atorvastatin-Teva ka calcium atorvastatin. Eia kekahi, ʻo ka hoʻonohonohoʻana o nā lāʻau lapaʻau me ka nui o nā mea kōkua. Hoʻopili kēia mau, no ka laʻana, ka lactose monohydrate, titanium dioxide, polysorbate, povidone, alpha-tocopherol.
Ke hana o ka hana o ka Atorvastatin-Teva
ʻO Atorvastatin-Teva, e like me ka mea i ʻōlelo ʻia ma ka mua, he ʻāpana waha i ka lipid. Ke hoʻoikaika nei kona ikaika a pau e kāohi, ʻo ia hoʻi, ke kāohi nei i ka hana a ka enzyme ma lalo o ka inoa HMG-CoA reductase.
ʻO ka hana nui o kēia enzyme ʻo ka hoʻoponopono ʻana i ka hoʻokumu ʻana o ka cholesterol, no ka mea, o ka hoʻokumu ʻana o kona mua, mevalonate, mai 3-hydroxy-3-methyl-glutaryl-coenzyme A. e hana mua ana i ka kolamu synthesized, hui pū me ka triglycerides, i hoʻouna ʻia i ka puʻuwai, kahi e hui pū ai me nā lipoproteins low low. . ^ E Ha yM. Hoʻokomo ʻia ka mea i hoʻokumu ʻia i loko o ke kahe koko, a laila me ka mea o kēia manawa e hāʻawi ʻia i nā kino ʻē aʻe a me nā ʻāpana.
Hoʻololi loa ʻia nā lipoproteins haʻahaʻa loa i nā lipoproteins haʻahaʻa haʻahaʻa ma o ka hoʻokaʻa ʻana ʻana i kā lākou mau mea kikoʻī. Ma muli o kēia hopena, hele kā lākou catabolism, ʻo ia ka pohō.
ʻO ka lāʻau lapaʻau ka hōʻemi o ka nui o ka kolamu a me nā lipoproteins i ke koko o nā mea maʻi, ke kāohi i ka hopena o ka hoʻopili a hoʻonui i ka nui o nā mea i komo i ka ate no ka lipoproteins low density. Hāʻawi kēia i ko lākou hopu hou a hoʻoiho. ʻO ke ʻano o ke kāpili ʻana o ka lipoproteins atherogenic a hoʻemi nui ʻia. Eia kekahi, ʻo ka ʻike o ka kolamu lipoprotein kūloko kiʻekiʻe e hoʻonui a triglycerides i iho me ka apolipoprotein B (ka lawe palapa).
Ke hōʻike nei ka hoʻohana ʻana o Atorvstatin-Teva i nā hopena kiʻekiʻe i ka mālama ʻana ʻaʻole o ka atherosclerosis wale nō, akā ʻo nā mea ʻē aʻe e pili ana me ka hana lipid metabolism, kahi o nā hopena lipid-hoʻēmi kūpono ʻole.
Loaʻa ʻia ka pale o ka hoʻomohala ʻana i nā maʻi e pili ana me ka puʻuwai a me nā kīʻaha koko, e like me ke hōʻiliʻili ʻana i ka puʻuwai a me nā hōʻeha.
Pharmacokinetics o Atorvastatin-Teva
Hoʻopau koke kēia lāʻau lāʻau. No nā hola he ʻelua, ua hoʻopaʻa ʻia ka kiʻekiʻe o ka lāʻau lapaʻau ma ke koko o ka mea maʻi. ʻO ke olakino, ʻo ia hoʻi, ʻo ka hoʻowalewale ʻana, hiki ke hoʻololi i kona wikiwiki.
No ka laʻana, hiki ke hoʻolōʻihi i ka wā e lawe ai i nā papa me ka meaʻai. Akā inā emi ka luhi, a laila ʻaʻole i hoʻopilikia i ka hopena o Atorvastatin ma kekahi ʻano - e hoʻomau mau ka cholesterol e like me ke ʻano. Ke komo nei i ke kino, noho ka lāʻau i ka hoʻololi ʻana presystemic i ka ʻeha gastrointestinal. Hoʻopaʻa loa ia me nā protein plasma - 98%.
ʻO nā loli nui o ka metabola me Atorvastatin-Teva e hele i loko o ka ate ma muli o ka ʻike i nā isoenzymes. A ʻo kahi hopena o kēia hopena, ua hoʻohālikelike ʻia nā metabolite ikaika, nāna ke kuleana no ka hoʻopau ʻana o ka HMG-CoA reductase. ʻO 70% o nā hopena o ka lāʻau lapaʻau e kū pololei ma muli o kēia mau metabolites.
Hoʻopili ʻia ʻo Atorvastatin mai ke kino me ka hua hepatic. ʻO ka manawa o ka lana o ka lāʻau i loko o ke koko e like me ka hapalua o ke kumu (a kapa ʻia ʻia ka hapalua o ke ola) he 14 mau hola. Hoʻopilikia ka hopena i ka enzyme e pili ana i kahi lā. ʻAʻole hiki ke hoʻoholo ʻia i ʻelua mau pakeneka o ka nui i ʻae ʻia e ka nānā ʻana i ka urine a ka mea maʻi. No nā mea maʻi me ka piha o ka renal, e hoʻomanaʻo ʻia i ka wā o ka hemodialysis Atorvastatin ʻaʻole i haʻalele i ke kino.
ʻOi aku ka kiʻekiʻe o ka lāʻau lapaʻau ma mua o ka maʻamau ma o 20% i loko o nā wahine, a ua hoʻemi ʻia ka nui o kona hōʻemi ʻia e 10%.
I nā maʻi e hōʻeha nei i ka hōʻeha o ka ate ma muli o ka inuʻana i ka waiʻona, e hoʻonui ka nui o ka piʻi e 16 mau manawa, a hāʻule ka nui o ka excretion me 11 mau manawa, he ʻokoʻa ʻole i ka maʻamau.
Nā hōʻailona a me nā contraindications no ke hoʻohana
ʻO Atorvastatin-Teva kahi lāʻau lapaʻau i hoʻohana nui i loko o ka hana lapaʻau hou.
Lawe ʻia ka mālama ʻana o kekahi o nā maʻi o luna a me nā ala i ka wā e mālama ana i ka ʻai e kōkua ana i ka hoʻokaʻawale ʻana o ke kolamu koko (kiʻekiʻe i nā lau momona a me nā hua, nā kīʻaha, nā huaʻai, nā huaʻai, nā mea kanu, nā moa, nā hua manu), a me ka hala ʻole o nā hopena mai mua noi ʻia.
Nui kekahi mau hōʻailona i hōʻike ʻo ia i mea maikaʻi loa:
- atherosclerosis;
- hypercholesterolemia mua;
- ʻo ka ʻohana heterozygous non-familial hypercholesterolemia;
- hoʻokaʻawale ʻia nā ʻano hypercholesterolemia (ʻano ʻelua e like me Fredrickson);
- triglycerides hoʻokiʻekiʻe (ʻehā ʻano e like me Fredrickson);
- ka mālamaʻoleʻana o nā lipoproteins (ke kolu o ke ʻano e like me Fredrickson);
- ʻO ka maʻi homozygous familial hypercholesterolemia.
Aia pū kekahi mau contraindications i ka hoʻohana ʻana o Atorvastatin-Teva:
- ʻO nā maʻi ʻeha ma ke kahua hoʻoikaika a i ʻole i ke ʻano o ka exacerbation.
- ʻO ka hoʻonui ʻana i ka pae o ka maʻi hepatic (ALT - alanine aminotransferase, AST - aspartate aminotransferase) ʻoi aku ma mua o ʻekolu mau manawa, me ke kumu ʻole kumu ʻole.
- ʻO ka hana hema ʻole.
- ʻŌpū a me ka lactation.
- Na kamalii o na keiki uuku.
- Hōʻike maʻalahi i ka wā e lawe ai i kekahi o nā mea pono o ka lāʻau.
I kekahi mau hihia, pono e kuhikuhi kēia mau penikala me ka akahele loa. ʻO kēia mau hihia penei:
- inu wai ʻā he inu ʻawaʻawa;
- hoʻokūkū palekana naʻau;
- Kōkuhi hormonal;
- nā hemahema o nā electrolytes;
- maʻi kīnā;
- ke koko haʻahaʻa;
- maʻi lēpaʻi maʻi āpau;
- epilepsy i hoʻopaʻa ʻole ʻia;
- nā hana nui a me nā hōʻeha traumatic;
Eia kekahi, e mālama pono i ka wā e lawe ai i ka lāʻau lapaʻau e pono e hana i ke alo o nā pilikia o ka ʻōnaehana o ka muscular.
Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau
Hoʻoholo ʻia ka nui o ka lāʻau e ka maʻi mua e koi ai i ka mālama ʻana, ka pae o ke kolamu, lipoproteins a me ka triglycerides. Eia nō hoʻi, ua mālama mau ʻia ka hopena o nā mea maʻi i ka hoʻomau maʻi. ʻAʻole i hilinaʻi ʻia ka manawa e lawe ai i ka lāʻau lapaʻau. Pono ʻoe e lawe i hoʻokahi papa ʻaila a i ʻole (ʻoi aku ma ke ʻano kauka a ke kauka) hoʻokahi i ka lā.
ʻO ka pinepine, ʻo ka hoʻohana ʻana o Atorvastatin-Teva e hoʻomaka me kahi hapa o 10 mg. Eia nō naʻe, ʻaʻole mau ka dosage a pau pono, a no laila e hoʻonui ʻia ka lāʻau. ʻO ka ʻae loa loa he 80 mg i kēlā me kēia lā. Inā makemake ʻia kahi hoʻonui o ka lāʻau lapaʻau, a laila e hui pū me kēia kaʻina, pono e mālama ʻia ka ʻike maʻamau o ka lipid pae a pono e koho ʻia ka lāʻau kūpono e like me lākou. Hoʻololi ʻia i ka papa o ka lapaʻau e pono ai ma mua o hoʻokahi mahina.
ʻO ka pahuhopu nui o ka lapaʻau ke hoʻohaʻahaʻa i ka cholesterol i kahi maʻamau. ʻO ke kumu o ka heluna nui o ke kolamu ma ke koko he 2.8 - 5.2 mmol / L. Pono e hoʻomanaʻo ʻia no nā mea maʻi e hōʻeha nei i ka palupalu o ke kō, pono paha e hōʻemi i ka hopena a hoʻopau paha i ka hoʻohana ʻana i ka lāʻau lapaʻau.
Nā hopena o ka lāʻau
I ka wā o ka hoʻohana ʻana o Atorvastatin-Teva, hiki i nā ʻano ʻano ʻino ʻē aʻe mai nā kakanina a me nā ʻōnaehana organ. ʻO kekahi mau hopena ʻaoʻao ka mea maʻamau.
Nā kikowaena waena a me ka peripheral: pilikia hoʻoluhi, nā hōʻeha, nā puʻuwai hoʻomanaʻo, nāwaliwali, nāu i hōʻemi a hūnā paha i ka naʻau, neuropathy.
ʻO ka ʻeha o ka gastastite: ka ʻeha o ka ʻōpū, ka luaʻi ʻana, ke nānā ʻana, ka nui o ka hoʻomohala i ka hau, constipation, indigestion, nā hana ʻalopela i ka palaleka a me ka pancreas, jaundice e pili ana me ka stagnation o ka bile, ka luhi.
ʻO ka ʻōnaehana musculoskeletal: ʻeha ma nā ʻuhane, ʻoi aku hoʻi i nā ʻili o ke kua, mālama i nā ʻaoʻao o ka naʻau, ka ʻāwili pū ʻana, rhabdomyolysis.
Nā hōʻike hoʻohālikelike: e ke ʻano o ka ʻāʻī o ka ʻili i ke ʻano o ka urticaria, ke aloha, ka hopena kūlohelohe koke i ke ʻano o ka anaphylactic shock, ke kīwī.
Hematopoietic ʻōnaehana: kahi emi i ka nui o nā platelets.
Pūnaewele metabolic: kahi hōʻemi a hoʻonui paha i ka glucose koko, kahi hoʻonui i ka hana o kahi enzyme i kapa ʻia ʻo creatine phosphokinase, edema o nā kiʻekiʻe a me nā haʻahaʻa haʻahaʻa, ʻoi ka momona.
ʻO kekahi: ua hōʻemi ʻia ka ʻūhā, hōʻeha i ka umauma, lawa ʻole i ka hana ʻalohi, ka lūlū māla, hoʻonui i ka ʻōpū.
No kekahi mau palaka a me nā kūlana, pono ke kuhikuhi ʻia ʻo Atorvastatin-Teva me ka makaʻala nui loa, penei:
- Hoʻohālikelike waiʻona;
- Hoʻoiho o ka ate;
- Hoʻopili i nā hoʻokolohua hana hana no ka maʻi kumu no ka ʻike ʻole ʻole;
Pono ʻia hoʻi ka mālama ʻana i ka wā e lawe ai i nā lāʻau lapaʻau anticholesterolemic, antibiotics, immunosuppressants, a me kekahi mau mau vitamina.
Hoʻopili me nā lāʻau lapaʻau ʻē aʻe
Hoʻopili ia Atorvastatin-Teva me ka hoʻomohala ʻana i ka myopathy - nāwaliwali ikaika o ka ʻiʻo, e like me nā lāʻau āpau nona ka hui o HMG-CoA reductase inhibitors. Me ka hoʻohana pū ʻana o kekahi mau lāʻau lapaʻau, hiki i ka ulu aʻe o ke kūkulu ʻana i kēia pathology hiki ke hoʻonui nui ʻia. ʻO kēia nā lāʻau lapaʻau e like me nā fibrates (ʻo kekahi o nā hui anticholesterolemic pharmacological), nā antibiotics (erythromycin a me nā macrolides), nā lāʻau antifungal, huaora (PP, a i ke ʻano nikotinic acid).
Hoʻopili kēia mau pūʻulu ma kahi o ka enzyme kūikawā i kapa ʻia CYP3A4, e hana ana i nā kuleana nui i ka metabolism Atorvastatin-Teva. Me kēia ʻano hui hoʻohui, hiki i ka nui o ka atorvastatin i ke koko ke hoʻonui i ka manaʻo no ka pale ʻana o ka enzyme i haʻi ʻia, ʻoiai ʻaʻole lapaʻau ʻia ka lāʻau lapaʻau. ʻO nā hoʻomākaukau e pili ana i ka pūʻulu o nā fibrates, no ka laʻana, Fenofibrate, e kāohi i nā kaʻina o ka hoʻololi o Atorvastatin-Teva, ma muli o kāna kumukūʻai i loko o ke koko e hoʻonui.
Ma Atorvastatin-Teva hiki ke alakaʻi i ka hoʻomohala ʻana o ka rhabdomyolysis - he ʻano puʻupuʻu koʻikoʻi kēia e hele nei e like me ka hopena o kahi ala lōʻihi o ka myopathy. Ma loko o kēia kaʻina hana, ʻike ʻia nā huaʻehā o nā aihue, ke nānā ʻia nei kā lākou mākēmi i ka urine, hiki ke hana i ka hāʻule ʻole o ka renal. Ka ulu pinepine ʻo Rhabdomyolysis me ka hoʻohana ʻana o Atorvastatin-Teva a me nā hui lāʻau lapaʻau ʻo luna.
Inā ʻoe e kuhikuhi i ka lāʻau lapaʻau i ka nui loa i ʻae ʻia i kēlā me kēia lā (80 mg i kēlā me kēia lā) me ka cardiac glycoside Digoxin, a laila he nui ka piʻi ʻana o ka neʻe o Digoxin e pili ana i ʻelima o ka huina i lawe ʻia.
He mea koʻikoʻi loa ia e hoʻopili pū i ka hoʻohana ʻana i ka Atorvastatin-Teva me nā lāʻau lapaʻau hānau e loaʻa ai ka estrogen a me nā mea e loaʻa ai iā ia, no ka mea aia ka nui o ka pae o nā wahine wahine. He mea nui ia i nā wahine o ka hānau ʻana.
ʻO ka meaʻai, ua kuhikuhi pono ʻia e hōʻemi i ka hoʻohana ʻana i ka wai ʻai, no ka mea ʻoi aku ka nui o nā mea ʻemi e pale ai i ka enzyme, ma lalo o ke kumu o ka hana o ka metabolism nui o Atorvastatin-Teva e piʻi a hoʻonui ʻia ke kiʻekiʻe o ke koko. Hiki ke kūʻai ʻia kēia lāʻau lapaʻau i kekahi lāʻau lapaʻau me kahi laʻana.
Hāʻawi ka ʻike e pili ana i ka lāʻau Atorvastatin i loko o ke wikiō ma kēia ʻatikala.
