Soluble kanaka genetically engineered engine a me nā mea a pau

ʻO ka hana o nā insulin i loko o ke kino he kū ʻole i ka overestimate. Loaʻa kekahi pae kiʻekiʻe o ka insulin i ka maʻi endocrine koʻikoʻi - maʻi diabetes. No 40 makahiki i hala aku nei, ua ola o ka maʻi maʻi ma mua o 10-15 mau makahiki.

Ke hoʻohana nei ka lāʻau lapaʻau hou i ka mea kūpono ponoʻenehana kūlohelohe kanaka kūpono i ka insulin e hoʻomaʻamaʻa i ke kiʻekiʻe o ka glucose koko. Mahalo i kēia lāʻau lapaʻau, ua pau ka hoʻomehana i hala, ua hāʻawi i nā mea maʻi i kahi manawa holoʻokoʻa a lōʻihi.

No ke aha i kapa ʻia ai ʻo insulin "genetically engineered"

Haumaha kekahi mau maʻi e ka huaʻōlelo "genetically engineered," e hoʻomanaʻo ana iā lākou no nā "GMO hewa."

ʻO ka mea maoli, ʻo ia ka mea inohua o kēia lāʻau lapaʻau i mālama i nā miliona o nā kānaka me ka maʻi maʻi.

I ka hoʻomaka, hoʻohana nā kauka i ka insulin i kaawale ʻia mai nā holoholona (ʻoi aku ka nui o ka puaʻa a me nā bipi). Eia naʻe, ʻaʻole kēia haole i kahi haole no nā kānaka, akā ua komo koke i loko o ke kahe wai, hoʻonāukiuki i ka lele i loko o ka glucose a loaʻa ai ka nui o nā hoʻopiʻi.

Hoʻokumu ʻia ka insulin soluble i ka nānā ʻana i nā pono a pau o ka mea maʻi me ka maʻi maʻi maʻi, e hōʻemi ana i nā ʻano maʻi like ʻole. Ma hope o ka pau ʻana o kāna hana, ke ʻoki loa nei ia i loko o nā waikawa amino maʻamau a hoʻopau ʻia mai ke kino.

ʻO nā waiwai nui pharmacological

ʻO ka insulin soluble kanaka e pili ana i nā lāʻau lapaʻau loli pōkole hana pōkole.

I ka manawa me ka mea hoʻonaʻauao pāpaona, hana i ka lāʻau lapaʻau i kahi mea hoʻonāwī i ka insulin e hoʻoikaika ai i nā hana intracellular:

1. ʻO ka noho kaʻawale o nā enzyme no ka hana piha a me ka assimilation o glucose i nā kiko;
2. Hoʻonui i nā neʻe intracellular a me ka piʻi aʻe o ka glucose;
3. Hoʻemi ka palena o ka hoʻokumu glycogen i loko o ka ate;
4. Hoʻomoe i ka hana o nā protein a me nā momona.

Me ka hoʻokele subcutaneous, hoʻomaka ka lāʻau lapaʻau e hana ma hope o 20-30 mau minuke, hiki i kona kiʻekiʻe i loko o 1-3 mau hola, e mau ana ma kahi o 5-8 hola.

Ua hoʻokaʻawale ʻia kēia lāʻau lapaʻau i nā ʻano kū i loko o nā umauma: no ka mea laʻana, ʻaʻole ia i komo i ka palaki plasenta a ʻaʻole i komo i ka waiū umauma. Ma hope o ka pau ʻana o kāna hana, ua hoʻopio ʻia ka insulin kanaka ma o nā ʻōpū (ma kahi o 80%) ma hope o kona luku ʻia e ka insulinase.

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka maʻamau, kuhikuhi nā kauka i ka soluble insulin i nā hihia o:

• Hoʻoikaika pilikino a i ʻole hui pū ʻana o ke ʻano type type 1 a me ke ʻano type mell 2 o ka mellitus;
• ʻO ke kūpaʻa piha a ʻāpana paha (kū'ē) o ke kino i ka waha (i lawe ʻia e ka waha) nā lāʻau antidiabetic;
• Na Diabetes mellitus i ka wā hāpai (inā he maikaʻi ʻole ka ʻai);
• ʻO nā hopena o ka maʻi mellitus maʻi (ketoacidosis, hypersmolar a i ʻole ketoacidotic coma);
• ʻO ke ʻano o ka mālama kino ʻana i ka maʻi diabetes ma kahi o ke ʻano o nā maʻi like ʻole;
• Ka hopena hoʻoweliweli ma ka maʻi ma ka maʻi āpau e kau ana ma ke ʻano wahaheʻe o ka lāʻau hoʻohiolo i ke kō (ka wā preoperative, nā maʻi koʻikoʻi, me nā mea hōʻeha a me ka haukulu, ma mua o ka hānau keiki ʻana, a me kekahi mea).
• ʻO ka nephropathy diabetic a i ʻole nā ​​maʻi hepatic;
• ʻO ka palaka ʻeha dystrophic (furunculosis, carbuncles, ulcers);
• Ke hoʻololi nei i ka insulin me ka hopena lōʻihi (lōʻihi).

Nā Hoʻohui

Hoʻopili ʻia no ka hoʻohana ʻana o ka insulin i:

• Ke hoʻohaʻahaʻa nei i ke koko koko (hypoglycemia);
• ʻO ka hoʻonui ʻana i ke ʻano o ka naʻau i ka insulin.

ʻO nā hopena ʻino

ʻOiai ke hoʻomanawanui maikaʻi, hiki i ka insulin ke loaʻa nā hopena i ka wā i hoʻohana ʻia:

1. ʻO ka hana ʻana o ka hypoglycemia ma muli o ka hōʻole ʻia o ka lāʻau e ke kino a i ʻole ka hopena immunological me kona insulin ponoʻī;
2. Allergic reaksi (urticaria, itching a koʻikoʻi koʻikoʻi Quincke edema me ka nui o ka ʻōpū o ka maka a me nā membula mucous, pallor a me ka pōkole o ka hanu);
3. ʻO ka comyp Hlyoglycemic;
4. Hoʻowahāwahā i ka ʻike āpau (hele pinepine i kahi coma);
5. ʻO ka Hyperglycemia a i ʻole acidic acidosis (e kū'ē i ke kua o ke kaaka a i ʻole nā ​​maʻi maʻi, kaʻai maikaʻi ʻole, ma hope o kahi hōʻeha a i ʻole ke kuhi hewa paha);
6. Ka loaʻaʻana o ka pono ma ke ʻano o ka makewai, ke hiamoe nei, hōʻemi iho i ka makemake, ʻulaʻula a ka maka;
7. ʻO nā kūloko kūloko i ka hoʻomaka ʻana me ka hoʻopili ʻana (ka puhi ʻana, ʻeha, ʻulaʻula, nā hele ʻana a i ʻole ka hoʻonaninani o ka kiko adipose).

E hui pū me nā lāʻau lapaʻau ʻē aʻe

Ke hoʻohana nei i ka insulin o ke kanaka me kekahi mau lāʻau lapaʻau, hoʻoikaika ʻia kona hopena hypoglycemic a nāwaliwali paha.

Hiki ke hoʻonui i ka hopena hoʻohaʻahaʻa honu i ka wā e lawe ai i ka insulin me:

1. Sulfonamides (sulfonamide a i ʻole nā ​​hypoglycemic agents);
2. Nā MAO inhibitors (furazolidone, etc.);
3. ʻAno inhibitors (captopril, enalapril, etc.);
4. Nā ʻae ʻia nā NSAIDs (aspirin, diclofenac, etc.);
5. Androgens a me anabolic steroid (Anavar, Androxon, etc.);
6. Nā lāʻau lapaʻau Antimalarial (quinoline, quinidine, etc.);
7. ʻEtrlelo paha (tetracycline, doxycycline);
8. ʻO nā lāʻau lapaʻau ʻē aʻe (theophylline, pyridoxine, morphine, etc.)

No ka hōʻemi ʻana i ka hopena hypoglycemic o ka lāʻau lapaʻau, ʻo kāna pilina me:

• Kūkākūkā
• Amphetamines;
• ʻO ʻEstrogens (me ka hoʻopili ʻana i nā mea hoʻohālikelike waha);
• Diuretics;
• Sympathomimetics;
• ʻO nā hormones thyroid
• ʻO ka hoʻolaʻa kaʻawale (triamterone, phenytoin, glucagon).

Eia kekahi, i ka hui pū me ka insulin, hiki i nā lāʻau ke hōʻemi a hoʻomaikaʻi paha i ka hopena hypoglycemic:

1. Nā Beta-blockers;
2. Reserpine;
3. Moramona;
4. ʻOihope.

Ke koho noi a me ka helu ʻana

Hoʻomau mau ʻia ka lāʻau a me ke ʻano o ka hoʻomehana ʻana o ka inika manuahi a ka mea e ka endocrinologist, me ka noʻonoʻo ʻana i nā ʻōuli pono o ke kaʻe o ke koko a me ka pā o ka mea maʻi.

Hoʻohana ʻia kēia lāʻau lapaʻau i ka maʻi maʻi i kekahi mau ala: subcutaneously (s / c), intramuscularly (i / m) a i ʻole intravenously (i / v). ʻO nā manawa pinepine, ʻo ka insulin i mālama ʻia e subcutaneously. No ka hana ʻana i kēia, e hoʻohana i ke kaha:

• O ka ʻōpū;
• Nahu;
• Hoʻopaʻa ka ʻili ma luna o ka poki.

Hoʻomaʻamaʻa pinepine ʻia ka lāʻau lapaʻau i loko o nā maʻi kūloko i hoʻonāukiuki ʻia e ka maʻi maʻi: ketoacidosis, maʻi koma maʻi.

Manea ʻia e hoʻokō i ka insulin 15-30 mau minuke ma mua o ka papaʻaina, ʻekolu manawa i ka lā. I kekahi manawa ua ʻae ʻia kahi hoʻokele hoʻokahi o ka lāʻau lapaʻau.

Hoʻolilo pinepine ʻia ka nui o ka insulin i ka hapa like o ka nui o 0.5-1 i ka 1 kg o ka paona. Inā mālama ʻia ka insulin ma mua o 0.6 mg pākeleka o ke koʻikoʻi o ke kino, a laila pono e lawelawe ʻia ka lāʻau i ka liʻiliʻi ma 2 mau lā i ka lā. I ka awelika, ʻo ka maʻi pākahi o kēlā me kēia lā e pili ana i 30-40 mau hui (i nā keiki, 8 mau ʻāpana).

ʻO nā wahine hāpai wahine e kuhikuhi pinepine ʻia i kahi mahele o 0.6 mau paona no ka nui o ka paona. Kuhi pinepine nā ʻōkuhi i nā manawa 3-5 i ka lā, e like me ka nui o nā meaʻai.

ʻO ka pinepine, ua hoʻohui pū ʻia ka insulin wikiwiki e hana me ka insulin hana lōʻihi.

Nā kānāwai hoʻokolohua Insulin

ʻOiai nā maʻi maʻi maʻi i hana hewa i ka wā e hoʻokele i ka insulin.

ʻO nā kānāwai koʻikoʻi no ka therapy insulin:

1. E nānā ana i ke ola o ka noho a me nā kūlana e waiho ai o ka lāʻau lapaʻau: ʻaʻole pono e ʻike ʻia i ka overheating a i ʻole hypothermia.
2. Hoʻopili i nā kīʻaha insulin. Lawa ka mālama ʻana i ka hue hoʻomaka i kahi wahiʻeleʻele i ka mahana o ka lumi.
3. ʻO ka hoʻomaikaʻi ʻana i ka helu o ka lāʻau lapaʻau me nā kauoha a me ke kauoha a ke kauka.
4. E hoʻokuʻu i ke ea mai kahi syringe ma mua o kahi maʻi. ʻAʻole pono e holoi i ka ʻili me ka waiʻona. Loaʻa nā maʻi me ka therapy insulin, a emi ka palaka i ka hopena o ka lāʻau.
5. Ke koho ʻana i kahi kūpono e hoʻolauna ai. No ka insulin-pōkole hana pōkole, ʻo ia ka ʻōpū. Ke hoʻoiho ʻia i ka ʻūhā a i ʻole lipilopiha, hana lohi ka lāʻau.
6. ʻO ka paleʻana i nā hoʻopiʻi ma ka pūnaewele injection i ke ʻano o ka hoʻohana ʻana i ka ʻāpana puni honua holoʻokoʻa. No ka hoʻolauna ʻana i ka insulin hana pōkole, hoʻohana ʻia ka ʻōpū holoʻokoʻa: mai ka piko o nā kihi kumu nui i nā paila siu, me nā ʻaoʻao o ka ʻeke. He mea nui e hoʻi i ka 2 cm mai nā pūnaewele injection kahiko, hoʻopuka i kahi syringe ma ke kihi o 45-60 degere, i ʻole ka lāʻau lapaʻau e holo.
7. Ma mua o ka lawelawe ʻana i ka lāʻau lapaʻau, ʻoi aku ka maikaʻi o ka lawe ʻana i ka ʻili i kahi kuʻi me ka manamana a me ka mua. Inā e hoʻokomo i ka ʻōpū, e hoʻēmi ana ka lāʻau lapaʻau i kāna hana. Ma hope o ka hoʻopili ʻana i ka pono, e paʻa i ka pūlapa no nā 5-10 kekona.
8. I loko o ka ʻōpū, hana ʻoi aku ka insulin hana pōkole 20 mau minuke ma mua o ka papaʻaina. I nā wahi ʻē aʻe, ke mālama ʻia nei ka lāʻau lapaʻau i ka hapalua hola ma mua o ka papaʻaina.

Trade inoa o ka lāʻau lapaʻau

Hoʻokumu ʻia ka Insulin i ke ʻano o ka hopena no ka ʻaihue a kūʻai ʻia aku i nā lāʻau lapaʻau.

Hiki i ke kinipona insanible manuahi i hiki ke hua ʻia ma lalo o nā inoa inoa.

• Biosulin;
• Actrapid;
• Actrapid NM;
• Gensulin;
• E alakaʻi no mākou;
• Penfill

Mahalo i nā ʻenehana genetic kahiko, ua hana ʻia nā mea kanu (recombinant) i hana ʻia e ka insulin kanaka. ʻO ia nō ka mea ikaika o nā hoʻomākaukau: Humodar, Humulin, Insuman, Gansulin, Humalog, Apidra SoloStar, Mikstard. He ʻokoʻa kēia mau lāʻau lapaʻau i ka mea mua ma ka ke ʻano o ka waikawa amino, e hoʻohui pū ana i nā waiwai hou iā lākou (no ka laʻana, he hopena ʻelua ala), he mea nui loa ia i nā maʻi me ka maʻi maʻi.

ʻO nā hopena ʻino

ʻOiai ke hoʻomanawanui iki, hiki i kēia lāʻau ke hopena i nā hopena ma ke ʻano:

• ʻO nā hopena immunological me ke insulin pono o ka mea maʻi;
• Allergic reaksi (urticaria, itching) a i ʻole ka edema o Quincke (me ka pa o ka maka o ka maka a me nā membula mucous, pallor,
• ʻO ka hanu, ka ʻili uliuli, a i ʻole ka nalowale ʻana o ka ʻike);
• ʻO ka comyp Hlyoglycemic;
• Ka ʻike hoʻoluhi (hele a hōʻea i ka coma);
• ʻO ka Hyperglycemia a i ʻole acidic acidosis (e kū'ē i ke kua o ke kaaka a i ʻole nā ​​maʻi maʻi, kaʻai maikaʻi ʻole, ma hope o kahi hōʻeha a i ʻole ke kuhi hewa paha);
• Na makewai, makewai, hoʻoneʻe i ka makemake, ʻulaʻula o ka maka;
• Nā hōʻike hōʻike i ka hoʻomaka me ka hoʻopuka ʻana (puhi, ukana, palu a hoʻohui ʻia paha o ka kiko adipose).

ʻO kekahi manawa i ka hoʻomaka ʻana o ka lawe i ka lāʻau lapaʻau ke hōʻike nei i ke ʻano o nā ʻano ʻike keu ʻole (ka ʻike pālua, ua ʻūhā, a me nā mea like) a me ke ʻano o ka edema. Akā kahi mea kūponoʻole i ke kino a hele i hope o kekahi mau pule o ka mālama ʻana.

Ke keu

Loaʻa ia i ka hoʻokele ʻana o ka insulin i kekahi mau hihia e alakaʻi i ka hyperglycemia.

ʻO nā mea nui ka maʻi hyperglycemia he mau hōʻike i ke ʻano o ka:

• Nāwaliwali;
• Pallor;
• E anu;
• Palpitations
• Ulo;
• Nā manaʻo o ka pōloli;
• Hoʻokomo ma ke kino;
• ʻUhane o ka ʻōlelo, nā lehelehe, nā wāwae.

I ka hoʻomaka ʻana o nā hōʻailona like, e lawe koke ka mea maʻi i kekahi mau aʻe momona me ka ʻai o ka hāmeʻa (maʻa mau lole ʻaina, kahi ʻāpana o ke kō a ʻona maikaʻi paha.

Nā hopena

ʻO ka lāʻau lōʻihi me ka insulin e hiki ke alakaʻi i nā hoʻopiʻi like ʻole. ʻO nā mea nui:

1. ʻO ka hopena nui o ka hypoglycemia. Hiki ke maʻalahi i kēia mau mea i kaʻai pono ʻole i ka papaʻai, ka nui o ka lāʻau, kaʻai nui, kaʻai a me nā maʻi o ka ate.
2. ʻO ka lipodystrophy postinjection. ʻO ka pale ʻana i nā patology o ka hoʻololi ʻana i ka pūnaewele injection, hoʻohui i ka ʻōnaehana novocaine (0.5-1.5 ml) i ka insulin, a hoʻokomo i kahi syringe i Ѕ o ka mānoanoa o ka puna adipose.
3. Ke kūleʻa o ka lāʻau. ʻO nā koho ʻē aʻe (e hui pū ʻia) i nā lāʻau lapaʻau haʻahaʻa e koho.
4. Allergic hopena pili. Hoʻopili i nā lāʻau lapaʻau paʻa (antihistamines, glucocorticoids) a me ka lawa o ka pono o ka lāʻau.

ʻO ka insulin soluble kanaka ka mea ola no nā maʻi maʻi maʻi maʻi he nui. Eia naʻe, pono e hoʻohana pono i kēia lāʻau lapaʻau me ka noʻonoʻo pono loa i nā lula āpau no kona alakaʻi. Pono ia e kuhikuhi i ke kauka i kēia lāʻau lapaʻau, helu i kona maʻi a nānā i ke ʻano o ka mea maʻi i ka wā o ka mālama holoʻokoʻa.