ʻO Glurenorm kahi lāʻau lapaʻau me ka hopena hypoglycemic. ʻO ke ʻano maʻi maʻi maʻamau ka maʻi koʻikoʻi ma muli o kona kiʻekiʻe ākea a me ka like o ke kiʻekiʻe o nā ʻōlapa. ʻOiai me ka pīhoihoi liʻiliʻi i ka hoʻoliʻi kūlohelohe, nui ka loaʻa o ka retinopathy, hōʻeha hōʻeha a hōʻeha paha.
ʻO Glurenorm kekahi o ka pōʻino e pili ana i ka hopena o nā hopena o nā hui antiglycemic, akā ʻaʻole ia e haʻahaʻa loa i ka hopena o nā lāʻau lapaʻau ʻē aʻe i kēia ʻano.
Lapaʻau
ʻO Glurenorm kahi kahu hypoglycemic i lawe ʻia ma ke alo. ʻO kēia lāʻau lapaʻau kahi derony sulfonylurea. Loaʻa iā ia ka pancreatic a me ka hana extrapancreatic. Hoʻonui ia i ka hana o ka insulin ma o ka hoʻopili i ka synt-glucose o ka synthesis o kēia hormone.
Ke hopena nei ka hopena hypoglycemic ma hope o nā hola 1.5 ma hope o ka hoʻokō kūloko o ka lāʻau lapaʻau, ʻo ka piʻi o kēia hopena ma hope o ʻelua a ʻekolu mau hola, lōʻihi mau hola 10.
Lapaʻau lāʻau
Ma hope o ka lawe ʻana i kahi pā hoʻokahi i loko, ua hoʻoiho koke ʻo Glyurenorm a kokoke a piha loa (80-95%) mai ke kaomi ʻana ma o ka ʻalo ʻana.
ʻO ka mea hana - glycidone, he pilina koʻikoʻi no nā protein i loko o ke koko koko (ma luna o 99%). ʻAʻohe ʻike e pili ana i ka hopena a i ʻole ka hele ʻana o kēia mau mea a i ʻole kāna huahana metabolic ma ka BBB a i ʻole ma ka plasenta, a me ka hoʻokuʻu ʻia o ka glycidone i loko o ka waiū o kahi makuahine hānai i ka wā lactation.
Ke waiho nei ka hapa nui o nā huahana glycidone metabolism i ke kino, i ka hoʻopili ʻia ʻana ma waena o nā mea ʻawaʻawa. ʻO kahi hapa liʻiliʻi o nā huahana wāwahi o nā huahana e puka mai ma o nā keiki.
Ua ʻike ʻia nā noiʻi ʻana ma hope o ke alakaʻi ʻana i loko, ma kahi o 86% o kahi mea i kapa ʻia isotope e hoʻokuʻu ʻia ma o nā ʻōpū. ʻO ka nui o ka nui o ka pākēkē a me ke ala o ka hoʻokele ʻana ma o nā keiki, ma kahi o 5% (i ka ʻano o nā huahana metabolic) o ka nui o ka lāʻau i kāhea ʻia. Ke kūpaʻa nei ka pae o ka hoʻokuʻu ʻana i nā lāʻau lapaʻau ma o ka liʻiliʻi, inā i lawe pinepine ʻia.
Hōʻike nā mea hoʻohalike o nā pharmacokinetics i nā mea maʻi a waena.
ʻOi aku ka 50% o ka glycidone e hoʻokuʻu ma o nā ʻōpū. Wahi a kekahi mau ʻōlelo, ʻaʻole i loli iki ka metabolism i ke ʻano inā ʻaʻole o ka mea maʻi i ka maikaʻi ʻole. Mai ka haʻalele ʻana o ka glycidone i ke kino ma o nā keiki i kahi liʻiliʻi loa, i ka poʻe maʻi me ka hiki ʻole o ka pale, ʻaʻole i hōʻuluʻulu ka lāʻau i loko o ke kino.
Nā Hōʻike
Pākuʻi ʻia i ka maʻi maʻamau i waena o nā makahiki he ʻelemakule.
Nā Hoʻohui
- ʻAno maʻi type 1
- ʻO ka hoʻonaninani hoʻonaninani huakaʻi;
- I ka piko maʻi maʻi
- ʻO ka hemahema o ka ate ma kahi hopena koʻikoʻi;
- ʻO kekahi maʻi lohi;
- ʻO ka makahiki ma lalo o 18 (no ka mea ʻaʻohe ʻike e pili ana i ka palekana o Glyurenorm no kēia ʻōpū o nā maʻi);
- ʻO ka hypersensitivity pilikino i ka sulfonamide.
E koi ʻia ka mālama ʻana i ka wā e lawe ai iā Glyurenorm ma ke alo o nā ala āpau:
- Kūʻai
- Maʻi maʻi thyroid;
- Ka maʻi waʻeha
Nā ʻōpala
Kuhi ʻia ka Glurenorm no ka hoʻohana kūloko. Kuhi pono ʻole i nā koi olakino e pili ana i ka nui o ke ana a me ka meaʻai. ʻAʻole hiki iā ʻoe ke pani i ka hoʻohana ʻana iā Glyurenorm me ke kūkā mua ʻole ʻana me kāu kauka.
ʻO ka hapai mua ka hapalua o ka paila i lawe ʻia me ka ʻaina kakahiaka.
Pono e hoʻopau ʻia ka Glurenorm i ka hoʻomaka mua o ka hoʻokomo ʻana o ka meaʻai.
Mai hōʻoki i ka ʻai ma hope o ka lawe ʻana i ka lāʻau.
Ke lawe ʻole i ka hapalua o ka paila e pono ole, pono ʻoe e nīnau i ke kauka nāna, ʻoi loa, e hoʻonui iki i ka papa.
I ka hana ʻana i kahi lāʻau e ʻoi aku ma luna o nā palena i luna, hiki ke loaʻa ka hopena i loaʻa ke kumu o ka hoʻokaʻawale ʻana i hoʻokahi mahele i kēlā me kēia lā i ʻelua a ʻekolu paha mau koina. ʻO ka hopena nui loa ma kēia hihia e hoʻopau ʻia i ka wā kakahiaka. ʻO ka hoʻonui ʻana i ka maʻa i nā papa ʻehā a i ʻole paha i kēlā me kēia lā, ma ke ʻano he kānāwai, ʻaʻole ia e hoʻonui i ka hana pono.
ʻO ka pā helu kiʻekiʻe loa i kēlā me kēia lā he mau papa ʻehā.
No ka poʻe maʻi me ka hana renal impaired
Ma kahi o 5 pakeneka o nā huahana metabolikini o Glurenorm e waiho i ke kino ma o nā keiki. Inā heleʻole ka mea maʻi i ka hana renal, ʻaʻole pono ka hoʻoponopono ʻana.
No nā mea maʻi me ka maʻi lēpa
Ke hoʻohana nei i ka lāʻau lapaʻau ma nā helu he 75 mg no nā mea maʻi e hōʻeha nei i ka hana hepatic maʻi lēwa, pono ka mālama ʻana e ke kauka. ʻAʻole pono e lawe ʻia ʻo Glurenorm me ka maʻi hepatic koʻikoʻi, no ka mea, ua hōʻemi ʻia ka 95 pakeneka o ka nui i ka ate a i waho o ke kino ma o nā ʻāpana.
Hoʻohui hui
Ma ka hihia o ka lawa ʻole o ka hoʻohana ʻana iā Glyurenorm me ka hoʻohui ʻole ʻana me ia me nā lāʻau lapaʻau ʻē aʻe, ʻo ia wale nō ke alakaʻi ʻana o ka metmorphine e like me ka mea i hoʻohui ʻia.
Nā hopena hopena
- Metabolism: hypoglycemia;
- CNS: nui ka ʻeha, ke poʻo, ka ʻeha luhi, nā maʻi paresthesia;
- ʻAkuhi: hypotension;
- ʻO ka hōʻiliʻili Gastrointestinal: ka nalowale o ka makemake nui, ka luaʻi, ka maʻi ʻaʻa, ka ʻeha ma ka ʻōpū, cholestasis.
Ke keu
Hōʻike huakaʻi: hoʻonui nui ʻia, ka pōloli, ka ʻeha, ka huhū, ka ʻōpū, nāwaliwali.
Mea hoʻōla: inā loaʻa nā hōʻailona o ka hypoglycemia, kahi komo kūlohelohe o glucose a i ʻole nā huahana e loaʻa i kahi nui o nā huamina. Ma ka hypoglycemia koʻikoʻi (i hele pū me ka nāwaliwali a coma paha), pono loa ka hoʻokele ʻana o ka dextrose.
Hoʻohui ʻano lāʻau
Hiki i ka Glurenorm ke hoʻomaikaʻi i ka hopena hypoglycemic inā e lawe pono ʻia me ka ACE inhibitors, allopurinol, painkillers, chloramphenicol, clofibrate, clarithromycin, sulfanilamides, sulfinpyrazone, tetracyclines, cyclophosphamides lawe ʻia e nā maʻi hypoglycemic.
Hiki i kahi nāwaliwali o ka hopena hypoglycemic i ka hihia o ka hoʻokele ʻana o ka glycidone me ka aminoglutethimide, sympathomimetics, glucagon, thiazide diuretics, fenothiazine, diazoxide, a me nā lāʻau e loaʻa ana i ka acid nikotinic.
Nā ʻōlelo kikoʻī
ʻO nā maʻi maʻi me ka maʻi maʻi maʻi e hoʻomau pono i nā ʻōlelo a ke kauka hele mai. He mea kūpono loa ia e nānā i ke kūlana i ka wā o ke kohoʻana i kahi hapa a i ʻole ka mea e hele ai i Glyrenorm mai kahi māke ʻē aʻe i loaʻa kekahi hopena hypoglycemic.
ʻO ka lāʻau lapaʻau me ka hopena hypoglycemic, lawe ʻia i ka waha ʻole, ʻaʻole hiki iā ia ke lawelawe ma ke ʻano he hoʻopiha piha no kaʻaiʻai e hiki ai iā ʻoe ke ʻohi i ke kaumaha o ka mea maʻi. Ma muli o ka hāhai ʻana i ka ʻai a hōʻino paha i nā kauoha a ke kauka, hiki i kahi nui o ke kahe ʻana o ke kōʻai koko ke hiki, e alakaʻi ana i ka palupalu. Inā ʻoe e lawe i kahi paila ma mua o kahi pāʻina, ma mua o ka lawe ʻana i ka hoʻomaka o ka ʻai, e ikaika ana ka hopena o Glyrenorm ma luna o ke kahe koko, no laila, hoʻonui ʻia ka hopena o ka hypoglycemia.
Inā loaʻa kahi mau hypoglycemia, kahi koi koke i ka huahana meaʻai i loaʻa ka nui o nā kō. Inā hoʻomau ka hypoglycemia, ma hope o kēia e ʻimi koke ʻoe i ke kōkua olakino.
Ma muli o ke koʻikoʻi o ke kino, hoʻonui paha ka hopena hypoglycemic.
Ma muli o ke komoʻana i ka waiʻona, hiki i ka hōʻemi a emi paha paha i ka hopena hypoglycemic.
Aia ka papa glyurenorm i ka lactose ma ka nui o ka 134.6 mg. Ua hoʻohālikelike ʻia kēia lāʻau lapaʻau no nā poʻe e loaʻa nei i kekahi mau puʻuwai hoʻoilina.
ʻO Glycvidone kahi derphative o ka sulfonylurea, ka mea i hoʻomohala ʻia e kekahi hana pōkole, no ka mea, ua hoʻohana ʻia e nā mea maʻi me ka maʻi type 2 a loaʻa iā lākou ka nui o ka hypoglycemia.
Loaʻa ka loaʻa ʻana o Glyurenorm e nā mea maʻi me ka maʻi maʻamau a me nā maʻi maʻi concomitant piha maoli. ʻO nā hiʻohiʻona wale nō ka holoi ʻanaʻana i nā huahana metabolly glycidone inactive i loko o nā mea maʻi o kēia ʻano. Akā i nā mea maʻi me ka hana hepatic maʻi lēpaʻa, he mea maikaʻi loa kēia lāʻau lapaʻau.
Hōʻike nā hōʻike i ke lawe ʻana iā Glyurenorm no hoʻokahi a meʻelima a ʻelima mau makahiki ʻaʻole ia e alakaʻi i ka hoʻonui ʻana i ke kaupaona kino, ʻoiai ke hiki ke hōʻemi iki i ka momona. Hoʻohālikelike nā haʻawina hoʻohālikelike o Glurenorm me nā lāʻau lapaʻau ʻē aʻe, ʻo nā derivatives o nā sulfonylureas, i hōʻike i ka hala ʻole o nā hoʻololi koʻikoʻi i nā mea maʻi e hoʻohana nei i kēia lāʻau lapaʻau no kahi o hoʻokahi makahiki.
ʻAʻohe ʻike e pili ana i ka hopena o Glurenorm i ka hiki ke hoʻokau i nā kaʻa. Akā pono e hoʻomaopopo ʻia ka mea maʻi e pili ana i nā hōʻailona hiki i ka hypoglycemia. Hiki i kēia mau hōʻike āpau ke kū mai i ka wā o ke ʻano me kēia lāʻau lapaʻau. Pono e mālama ʻia i ka wā e holo ʻia ana.
ʻO ka hapai, ka hoʻomaʻamaʻa
ʻAʻohe ʻike e pili ana i ka hoʻohana ʻana o Glenrenorm e nā wahine i ka wā hāpai a me ka lactation.
ʻAʻole maopopo ia inā maopopo ka glycidone a me nā huahana metabolic i loko o ka waiū umauma. Pono nā wahine hāpai i ka maʻi maʻi e nānā pono i kā lākou koko.
ʻO ka hoʻohana ʻana i nā lāʻau lapaʻau maʻi waha no nā wahine hāpai ʻaʻole hana i ka kaona o ka metabolism e pono ai. No kēia kumu, ke lawe nei i kēia lāʻau lapaʻau i ka wā hapai a me ka lactation
Inā hele a hāpai paha i ka wā hāpai a i ʻole e hoʻolālā iā ia i ka wā o ka mālama ʻana me kēia mākaʻi, pono ʻoe e kāpae iā Glyurenorm a hoʻololi i insulin.
I ka hihia o ka hana kolohe
No ka mea ua hoʻopili ʻia ka nui o ka Glyurenorm ma waena o nā ʻōpū, i loko o nā mea maʻi e hoʻonele ʻia ana kāna hana ʻana, ʻaʻole i hōʻiliʻili ʻia kēia lāʻau lapaʻau. No laila, hiki ke hāʻawi ʻia me ka ʻole o palena i nā poʻe e pili ana i ka nephropathy.
Ma kahi o 5 pākēneka o nā huahana metabola o kēia lāʻau lapaʻau ke hoʻopili ʻia ma o nā keiki.
Ua hōʻike ʻia kahi hōʻike e hoʻohālikelike i nā maʻi me ka maʻi a me nā hana ʻole o nā ʻano hanu o nā ʻano like ʻole, me ka poʻe maʻi e hōʻeha nei i ka maʻi maʻi maʻi, akā ʻaʻole naʻe i hana ʻia kahi hana renal, hōʻike ʻia ka hoʻohana ʻana o 50 mg o kēia lāʻau lapaʻau ka hopena like me ka glucose.
ʻAʻole i hōʻike ʻia kahi hōʻike o ka hypoglycemia. Mahope mai keia mea no ka poe maʻi i loaa ole ka hana renal hele, ʻaʻole pono.
