"Ma muli o ka hoʻonui nui o ka maʻi maʻi i ka honua i kēia mau makahiki i hala aku nei, ke nānā pinepine ʻia ka pancreas ʻaʻole he mea hoʻowalewale, akā he ʻano mea e hoʻohālikelike ai i ka insulin - ka hāmeʻa e hoʻoponopono ana i ke kō koko.
Akā ʻo ka mea nāna i manaʻo nona iho nā luuluu a ka maʻi pancreatitis kūlohelohe, ua lōʻihi ʻo ia i ka ʻike ʻana i ka lipase kahi mea e hōʻeha ʻia i nā ʻaka e hele mai me ka ʻai, a me ka pōʻino ʻole i ka wā e hāpai ʻia ai kēia lipase i ke koko.
He aha ka lipase?
ʻO ka ʻōlelo maloʻo kahi ʻepekema panepili lipase ka hoʻoneʻe ʻana i ka huaʻala mai ka subclass o nā esterases (ma ka papa o nā hydrolases) a kākau i ka ʻano like o nā waiwai me ka lipase hepatic blood.
Ke hoʻoholo nei i nā mea i luna, pono e wehewehe ʻia nā hydrolases e hoʻopili i nā pūhui kemu-biocatalysts (enima) e hōʻoli ai (hoʻohiolo) i nā momona momona (triglycerides) i ka glycerol manuahi a me nā mea mai nā papa momona momona kiʻekiʻe.
I nā huaʻōlelo ʻē aʻe, me ka ʻaʻohe o ka hoʻopili ʻana o kēia enzyme, ʻo ia kahi o ka peka o ka pancreatic wai, ʻaʻole hiki ke lilo ʻole ke ʻano o ka hoʻouka ʻana o nā momona i ke kino, a ʻaʻole hoʻi i ka momona momona i loko o ia mea, ʻo ia ka ola i like. No nā kīʻaha, ʻo ke kelepona a me ke ʻano o nā mālama, pono i ke kino ke hoʻokō i nā pahuhopu he nui - mai ka hana ʻana i nā mea hoʻolaʻa cell compact, durable, selme permeable no ka pale ʻana i ke kino mai nā pilama a me nā pōhā inā hāʻule i hope (alo i luna - me kou kua a me ka waiwai pio i lalo).
Nā hana o nā mea i loko o ke kino
I nā keiki hou, o nā lipases āpau i loko o ke kino, komo mua ka lipase komo i ka pāʻani - he enzyme e lawelawe ana e emulsify (hoʻoneʻe i kahi ala kūpono no ka honi ʻana) nā ʻāmū waiu momona (triacylglycerols) pololei i ka waha, no ka mea kēia mea hua ʻia e nā kuhi e lawelawe ana i ka lua waha.
Loaʻa i ke kino o nā keiki nā hiʻohiʻona:
- ka ulu wikiwiki a me ka hoʻomohala ʻana o ke kino a me nā ʻōpala ʻaʻole i kuhikuhi i ka hana ʻana o nā hale kūʻai glycogen koʻikoʻi;
- ʻaʻole i hoʻopiha ʻia ke kaʻina fermentation glucose.
I ka nānā ʻana i kēia, ʻo nā triacylglycerols (he mau triglycerides nō hoʻi, nā triglycerol, nā momona kūleʻa, nā momona momona), ʻokoʻa i ka ʻikepili nui o nā momona momona saturated, ka hana maoli ke kumu o ka ikaika wale nō, akā no ka wela i ke kino o ke keiki.
No ka mea, ʻaʻohe ka lawena pākeke i nā enzyme e hōʻiliʻili ai i ka hoʻōla ʻana o ka lipid i loko o ka waha, a ʻo ka nui o ka triacylglycerols i paʻa i loko o ka ʻōpū ma ka lipase o kona wai ka liʻiliʻi, ʻo ia ka mea nui o ka hoʻolaʻa mau loa o ke ola ua hoʻoneʻe ʻia i ka lumen o ka ʻāpana o ka ʻōpū i kapa ʻia ʻo ia ʻōpio liʻiliʻi - ma kahi kikoʻī. , ua kapa ʻia ka duodenum (ʻo ia ko lākou keʻena mua).
Inā hana iki ka hana o ka enzyual lingualima o ka umauma waiū, a no ka gastric lipase ʻo ia ka haʻalulu ʻana o nā tributirins o nā ʻaila like ʻole, a laila (ʻaʻole like hepatic lipase, ka mea i hana ʻia i ka wāwahi o ka VLDLP o kahi haʻahaʻa haʻahaʻa loa a me nā chylomicrons) - loaʻa i nā momona me ka meaʻai a ua hana ʻia ma ka hana ʻāpana me nā kaomi ʻohiola.
Akā, ʻaʻole hana maoli kēia molina digestion koʻikoʻi - no kāna hana kūleʻa, pono kekahi mau kumu hou aʻe.
- nā calcium calcium (no ka mea, he pancreatic lipase he enzyme e hilinaʻi nei i ka calcium);
- ka waha mua i nā momona momona e ka ʻili huna i hūnā ʻia i ka ʻōpū o ka wahī e ka ate.
ʻO ka mea maoli ia e "hoʻolōʻihi" i ka proenzyme (ʻoi aku ka huaheʻe mua ʻole) o ka prolipase i ka pāme pancreatic piha, pono ia e hoʻomaka i ka duodenum e ka hana o nā waikawa bile, a me ka colipase, kekahi o nā huina o ka wai pancreatic.
Hoʻomaopopo i ke kumu he nui nā "hoʻoikaika biochemical" i hana ʻia, kōkua ia ke hoʻomaopopo i ka pono o ka lipase:
- hoʻohemo, hana ʻana a hoʻokaʻawale i nā momona i nā ʻāpana ʻē aʻe;
- ka hoʻohālikelike o ka hui o ka momona-soluble o nā huaora (A, K, E, D), a me nā momona momona o ka polyunsaturated spectrum;
- hoʻomau i ka pae o ka ikehu o ka ikehu a lawe ʻia e nā lipids plasma.
Hoʻokumu ke kūlana o nā ʻōnaehana kino he nui i ka pae o ka lipre pancreatic.
No laila, ma muli o kona hemahema, ke kūlana o:
- dyslipoproteinemia (ma keʻano kūikawā, i ka ʻano IA hyperlipoproteinemia);
- nā mea hoʻonāukiuki i loko o nā lipoproteins serum;
- KKAHUAHOA IHD (Ka Mahele ʻeha Coronary);
- xanthomas (me ka makemake e pālahalaha);
- ka hanana o ka malabsorption (kaomi ʻana o ka hanu) o nā mokika momona lōʻihi.
Noho mau i ka hoʻohui i ka hana nui loa o ka enzyme pancreatic gland i ka alkaline pH o 8-9 (ʻoiai kahi hōʻailona o ka 4-5 e hōʻemi nui ana i ka hana o ka cleavage o emulsified triacyl glycerols).
Ma muli o ke ʻano o nā maʻi, nui ka nui o ka hana o kēia enzyme (me kona komo ʻana i loko o ke koko), ʻo ka mea i loko o kēia ʻano wai hoʻonaninani e hiki ai iā mākou ke hoʻokolokolo i ka hele ʻana o nā maʻi o ke kino a me nā kūlana pathological o ke kelepona pancreatic. No laila, ʻo ka manaʻo o nā kinakene ma ke koko (i luna a i lalo) e lawelawe ana me ka hoʻomaʻamaʻa ana o ka diagnostic no kekahi mauʻano o ka hoʻokaumaha somatic.
Haʻi wikiō ma nā enzymes:
ʻO nā kumu no ka Hoʻoulu Enzyme
Hāʻawi ʻia ka hana lipase ma ke koko (e like me ke aʻo ʻana e ka ʻaoʻao turbidimetric) ma kahi o 190 mau ʻāpana / ml no nā kāne a me nā wahine, no nā keiki ma lalo o 18 mau makahiki - i loko o 130 mau kumuwaiwai / ml (mau kumuhana o ka hana enzymatic i 1 ml o ke koko), he piʻi ma kēia hōʻailona hiki ke hōʻike i nā maʻi hana kanalua a me nā ʻōnaehana systemic.
No laila, he keu nui i loko o ke koko (me ka nele o ka manawa like i loko o ka digestive tract) he ʻano ʻano o:
- lōkohu
- nā mumū o ka kelepa pancreatic;
- kūlohelohe kūlohelohe o ka humuhumu;
- nā pilikia ʻoi (nā mahele o ke colic biliary, myocardial infarction).
ʻO ke kiʻi like mai ka:
- pōpilikia ʻana;
- peritonitis;
- Hoʻokomo ʻia nā iwi a me nā hōʻeha hōʻeha koʻikoʻi.
Ka like like me nā ʻōnaehana ʻōnaehana:
- ahonui;
- kohola
- diabetes mellitus;
- pilikia ʻole;
- umauma maʻi 'aʻai.
Nā kumu haʻahaʻa
ʻO nā kumu no ka hoʻohaʻahaʻa i nā pae serum lipase pae hiki ke:
- ka nui o ka momona triglyceride i loko o ka meaʻai i ʻai (irrational, ʻaiʻai ʻole);
- systemology (oncological) pathology (koe, akā naʻe, ka maʻi o ka pancreas iho);
- nā kumu ʻē aʻe, ʻaʻole i ʻike pinepine ʻia (a i ʻole ka paʻakikī paha).
Hiki pū i ka lipase haʻahaʻa.
- hoʻoilina ʻōpiopio;
- me ka neʻe o ka maʻi pancreatitis i kahi kūlana maʻi.
I ka hopena hope loa, he hopena paha kēia kūlana:
- nā cystic fibrosis;
- nā cystic fibrosis;
- ka nele o kahi pancreas (ma muli o kāna hana hoʻonā).
