ʻO Glimecomb e pili ana i nā lāʻau i hoʻohana ʻia no ka maʻi diabetes type 2.
He lako nā mea i hui pū ʻia me ka hypoglycemic.
Ma hope o ka lawe ʻana i ka lāʻau, ua hoʻomaopopo ʻia ka normalization o ka pae glucose i ke koko o ka mea maʻi.
ʻO ka ʻike nui, ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu
ʻO ka lāʻau lapaʻau i koho ʻia e pili ana i nā mea hoʻohana hypoglycemic i lawe waha ʻia. ʻO ka hāmeʻa pono kahi hopena hoʻohui. I ka hoʻonuiʻana i ka hopena o ke kō, ua loaʻa iā Glimecomb kahi hopena pancreatic. I kekahi mau hihia, loaʻa ka hopena i ka hopena extrapancreatic.
ʻO ka hoʻonohonoho o ka lāʻau pili ka metformin hydrochloride i ka nui o 500 mg a me Gliclazide - 40 mg, me nā mea laea sorbitol a me ka sodium croscarmellose. ʻO kahi liʻiliʻi, nā magnesium stearate a povidone aia i ka lāʻau lapaʻau.
Loaʻa ka lāʻau lapaʻau i ke ʻano o nā cylindrical tablet i loko o ke keʻokeʻo, kaʻaila a i ʻole nā ʻulaʻula hoʻi. No nā papa, ʻae ʻia ka marbling. He pōpilikia a nā pōpō a me kahi bevel.
Hoʻololi ʻia ʻo Glimecomb i nā papa he 10 i loko o nā pūʻulu blister. ʻO ka pūpū he 6 mau pā.
Pharmacology a me ka pharmacokinetics
ʻO Glimecomb kahi lāʻau lapaʻau hoʻohui e hoʻohui i nā ʻenehana hypoglycemic o ka pūʻulu biguanide a me nā derivatives sulfonylurea.
Hoʻohālikelike ka lālā i nā hopena pancreatic a me nā hopena extrapancreatic.
ʻO Gliclazide kekahi o nā mea nui o ka lāʻau lapaʻau. He huaʻai ia he sulfonylurea.
Ua kōkua ka waiwai i ka:
- hana hana insulin;
- ka emi ʻana o ke kaila o ke koko;
- hoʻemi i ka hoʻopili ʻana o nā platelet, ka mea e pale ai i ka hoʻokumu ʻana o nā māka koko i loko o nā moku;
- ʻano maʻamau o ka vvaima koi.
Hoʻopili ke Gliclazide i ka hopena o ka microthrombosis. I ka wā lōʻihi o ka hoʻohana ʻana i ka lāʻau i loko o nā mea maʻi me ka nephropathy maʻi, ʻike ʻia kahi hōʻemi i ka proteinuria (ʻo ka noho ʻana o ka protein i ka urine) ua ʻike ʻia.
Hoʻopilikia ke Gliclazide i ke kaumaha o ka mea maʻi i lawe i ka lāʻau. Me kahi papaʻai kūpono i nā poʻe maʻi me ka maʻi diabetes e loaʻa iā Glimecomb, ʻike ʻia ka nui o ka kaumaha.
ʻO Metformin, kahi ʻāpana o ka lāʻau lapaʻau, e pili ana i ka hui biguanide. Hoʻonui ka mea i ka nui o ka glucose i ke koko, ke kōkua pono e hoʻonāwaliwali i ke kaʻina o ke kīʻaha o ka glucose mai ka ʻōpū a me ka ʻawa. Kōkua ʻo Metformin e hana wikiwiki i ke kaʻina hana e hoʻohana ai i ka glucose mai nā kino kino.
ʻO nā mea haʻahaʻa e hoʻemi nei i ka cholesterol, nā lipoproteins haʻahaʻa haʻahaʻa. I kēia hihia, ʻaʻole i pili ka Metformin i ka pae o nā lipoproteins o kahi kūʻokoʻa ʻē aʻe. E like me Glyclazide, hōʻemi i ke kaumaha o ka mea maʻi. ʻAʻohe hopena i ka haʻalele ʻana o ka insulin i ke koko. ʻAʻole ia e hāʻawi i ke ʻano o nā hopena hypoglycemic. ʻO nā Gliclazide a me ke metformin ʻokoʻa ʻē aʻe a hoʻopuka ʻia mai ka mea maʻi. Hoʻohālikelike ʻia ka Gliclazide e kahi kiʻekiʻe o ke komo ʻana ma mua o ka Metformin.
ʻO ka pae kiʻekiʻe loa o Gliclazide i ke koko ua loaʻa ma hope o 3 mau hola mai ka manawa o ka hoʻonā ʻana o ka lāʻau. Hoʻopau ʻia ka waiwai ma o nā keiki (70%) a me nā ʻōpū (12%). Hōʻea ka hapa hapa-ola e 20 mau hola.
ʻO ka bioavailability o Metformin he 60%. Hoʻonui nui ka mea i loko o nā kaila koko ʻula. ʻO ka hapalua-ola kahi 6 hola. ʻO ka hoʻihoʻi ʻana mai ke kino e hele mai ana ma o ke keiki, me ka pūpū (30%).
Nā hōʻailona a me nā contraindications
Hoʻomaopopo ʻia ka lāʻau lapaʻau no nā maʻi maʻi me ka maʻi diabetes type 2 inā:
- ʻo ka hoʻomaʻamaʻa mua ʻana me ka papa ʻaina a me ka hoʻomaʻamaʻa ʻaʻohe i kūpono kūpono;
- aia kekahi mea e pono ai e hoʻololi i ka hui hoʻohui ʻana i hoʻohana ʻia me ka hoʻohana ʻana iā Gliclazide me ka Metformin i nā maʻi me nā maʻi hoʻoliʻi koko.
Hōʻike ʻia ka lāʻau lapaʻau me kahi papa inoa o nā contraindications, ma waena o ia:
- ka helehelena o ke ʻano maʻi type 1;
- ka hoʻomaloka pilikino ʻana i nā mea o ka lāʻau lapaʻau;
- hana koʻikoʻi kahi keiki;
- hapai
- pūpū hema;
- lactic acidosis;
- hana ʻole naʻau;
- maʻi koma maʻi;
- lactation
- nā maʻi āpau;
- myocardial infarction;
- maʻi maʻi porphyrin;
- precoma hoʻokaʻawale;
- kaʻaila mua;
- ka manawa o ka mea maʻi e hana ana i nā haʻawina X-ray a me nā hoʻokolohua e hoʻohana ana i nā radioisotopes me ka hoʻokumu ʻana i nā mea iodine-kūlike (ua pāpā ʻia i nā lā 2 mau lā ma hope a ma hope o kēia mau haʻawina);
- ʻeha hōʻeha;
- nā hopena kūwaho e pili ana i kahi kūlana o ke naʻau a me nā maʻi lohi;
- ke aho hanu;
- mai ka waiʻona make;
- kaohi koko haʻahaʻa (hypoglycemia);
- ʻehaʻeha koʻikoʻi;
- lāleʻa hemahema;
- ʻā ʻia ka wela ma ke kino;
- pili i nā mea maʻi me kahi meaʻai hypocaloric;
- lawe ʻana i ka miconazole;
- maʻi ketoacidosis maʻi.
Nā ʻōkuhi no ka hoʻohana a me nā ʻōlelo aʻoaʻo kūikawā
ʻO ka nui o ka lāʻau lapaʻau ka kū hoʻokahi no kēlā me kēia maʻi. Hoʻomaopopo ʻia e lawe i nā papa 1-3 i kēlā me kēia lā. I ka lā e hiki mai ana o ka hoʻomaʻamaʻa ʻana, hiki ke hoʻonui ʻia i ke kinikona, e pili ana i nā hōʻailona o ke kō i loko o ke koko o ka mea maʻi a me ka pae o ka hōʻike o kona maʻi. No Glimecomb, ʻo ka nui loa ka nui o nā papa he 5 papa i kēlā me kēia lā.
Pono ka lāʻau e inu ʻia i ka kakahiaka a me ke ahiahi. Lawe ʻia ka lāʻau lapaʻau i ka wā a ma hope o ka ʻaina.
ʻAʻole ia e hōʻike ʻia i ka mea hana no ka poʻe maʻi ma mua o 60 mau makahiki, e hana ana i nā kūlana olakino. Me ka hana ikaika a ka lawe ʻana iā Glimecomb i ka poʻe ʻelemakule, hoʻomohala ka lactic acidosis.
ʻO ka hāpai ʻana kekahi o nā contraindications i ka lawe ʻana i kēia lāʻau lapaʻau. I ka wā e ulu ai ka wā hāpai, ma mua o kona hoʻolālā ʻana, pono e hoʻololi i ka lāʻau lapaʻau me ka lāʻau hoʻomehana insulin.
ʻO ka ʻōpala hoʻi kahi contraindication ma muli o ke kaʻe o ka nui o nā mea o ka lāʻau i loko o ka waiū umauma. Pono e hoʻopau i ka hānai no ka manawa lawe i ka Glimecomb e ka makuahine a i ʻole hoʻi e lawe i ka lāʻau lapaʻau iho i ka wā o ka lactation.
Me ke akahele, pono e lawe i kēia lāʻau lapaʻau i nā mea maʻi me:
- fiva;
- nā pilikia thyroid;
- lawa adrenal.
Lā ʻia ka lāʻau lapaʻau no nā maʻi me nā maʻi o ka puʻuwai, me ka hana ʻole o ka pūpū māmā, i hele pū me ka haʻalulu, dehydration, a me nā mea koʻikoʻi koʻikoʻi.
Lawe ʻia ka lāʻau i lalo i kahi meaʻai haʻahaʻa-haʻahaʻa me kahi haʻahaʻa haʻahaʻa o ka haʻahaʻa. I ka wā mua o ka mālama ʻana, e koi ʻia ka mālama ʻana i ke kōʻai koko. ʻO ka ʻoihana me ka lāʻau lapaʻau e lawe wale ʻia ma nā mea maʻi e loaʻa ka meaʻai maʻamau.
ʻO Sulfonylureas, kahi ʻāpana o ka lāʻau lapaʻau, hiki ke hoʻonāukiuki i ka hypoglycemia. Loaʻa ia me ka meaʻai haʻahaʻa-calorie a me ka hana kino. Pono e hoʻoponopono mau i ka lāʻau o nā lāʻau, a no nā mea maʻi maʻi.
Hiki i ka hypoglycemia ke maʻi i nā maʻi i ka wā e lawe ai:
- etilika waiʻona;
- ole-lāʻau lapaau anti-inflammatory.
Hoʻonui ka ʻai i ka wikiwiki i ka hopena o ka hypoglycemia i nā maʻi, a me nā mea kanu e like me ka reserpine me ka clonidine mask.
I loko o nā hihia o ka hoʻokō ʻana i nā maʻi i nā mea maʻi, inā e puhi ana, ʻeha, nā maʻi maʻi me ka ʻala, a me myalgia, lactic acidosis, hoʻopau koke ka wā i ka lāʻau.
Hiki i ka lāʻau ke hōʻake i ka hoʻokele. E mālama pono ʻia.
Pono ia e hooki i ka lawe ʻana iā Glimecomb i 2 mau lā ma mua a ma hope o ke komo ʻana i ke kino o ka mea maʻi e lilo ai i mea e i ka radiopaque me iodine.
Nā hopena ʻaoʻao a me ka overdose
I waena o nā hopena hopena e loaʻa mai ma muli o ka hoʻohana pono ʻana i ka lāʻau lapaʻau hiki ke loaʻa:
- hypoglycemia me ka ʻoluʻolu koʻikoʻi, nāwaliwali, huki, ka pololi, a me ka nāwaliwali;
- lactic acidosis me ka hiamoe, puʻuwai haʻahaʻa, nāwaliwali, nā ʻeha o ka ʻōpū, myalgia;
- ninini
- anemia
- nā pilikia maka;
- urticaria;
- hui vasculitis;
- nā ninia
- huu
- hemolytic anemia;
- huu
- erythropenia;
- i nā hanana pinepine, hepatitis;
- pūpū hema.
ʻO ka hōʻailona maʻamau o ka overdose ka hypoglycemia a me ka lactic acidosis. Hōʻike nā ʻokoʻa ʻelua i ka mālama ʻana i ka haukapila. I nā kūlana ʻelua, ua pau ka lāʻau lapaʻau. I ka hihia mua, loaʻa ka mea maʻi i ka mālama lapaʻau, hana ʻia ka hemodialysis.
Me ka hypoglycemia maʻalahi a me ka maʻalahi, e lawa i nā mea maʻi e lawe i kahi hopena o ke kō i loko o loko. Ma ka hoʻohālikelike nui, lawe ʻia ka glucose i ka intravenously i ka mea maʻi (40%). ʻO kekahi koho e lilo i glucagon, mālama ʻia ka intramuscularly a me ka subcutaneously. Hoʻomaʻamaʻa hou ka hana me ka mea maʻi i lawe i nā meaʻai momona.
Nā Kūleʻa Kūʻai a me nā Analog
Hoʻopili ka lāʻau lapaʻau me nā lāʻau ʻē aʻe penei:
- hoʻōla ʻia ka hopena hypoglycemic i ka wā e hui pū me ka enalapril, cimetidine, miconazole, clofibrate, ethionamide, anabolic steroids, cyclophosphamide, tetracycline, reserpine a me nā mea ʻē aʻe me ka hopena hypoglycemic;
- hoʻemi i ka hopena hypoglycemic i ka wā e lawe pū ʻia me Clonidine, Phenytoin, Acetazolamide, Furosemide, Danazole, Morphine, Glucagon, Rifampicin, ka waikū nikotinikia i loko o kahi mahele nui, estrogen, lithium salts, contraceptives waha;
- lawelawe me ka nifedipine e lohi ana i ka kaila o ka metformin;
- ka hui pū me nā hana cationic i hoʻonui i ka nui o ke kao o ka metformin i ke koko ma o 60%;
- hoʻonui i ka paʻa o ka metformin co-luna o ka lāʻau me ka furosemide.
Loaʻa iā Glimecomb ka hoʻohālikelike a me ka hoʻopili:
- ʻO Glidiab;
- ʻO Glyformin;
- ʻO Glidiab MB;
- Gliformin Prolong;
- Metglib;
- Formmetin;
- Glyclazide MB;
- Diabetalong;
- ʻO Gliclazide-Akos.
Hōʻike ka pale wikiō i nā hōʻailona a me ka mālama ʻana i ka maʻi maʻi:
Nā koho o nā loea kūikawā a me nā maʻi
Mai nā loiloi o nā maʻi, hiki ke hoʻoholo ʻia e hoʻemi maikaʻi ʻo Glimecomb i ke kō koko koko a maikaʻi hoʻi, akā hoʻi, ke hoʻomau nei nā kauka i kona mālama ʻana no ka nui o nā hopena o ka ʻaoʻao.
Lā maikaʻi maikaʻi ʻo Glimecomb no ka maʻi maʻamau o ka lā 2. Akā hāʻawi i nā mau contraindications iā ia, ua manaʻo ʻia e kuhikuhi me ke akahele i nā mea maʻi. Nui nā ʻelemakule.
ʻO Anna Zheleznova, 45 makahiki, endocrinologist
ʻO ka lāʻau maikaʻi no ka mālama ʻana i ke kō koko. Ua lawe ia iaʻu no hoʻokahi mahina, ʻaʻohe mau ʻina hoʻopili, ʻoiai aia ka nui o lākou i nā ʻōlelo aʻoaʻo. Hoʻoluʻolu ʻia me ka kumukūʻai.
Aloha, 57 makahiki
Ua nui wau i ka maʻi maʻamau i ka maʻi maʻamau no 2. ʻAe wau iā Glimecomb. He maikaʻi loa ka lāʻau lapaʻau a ʻaʻole ʻoluʻolu loa. E hōʻemi maikaʻi ia i ke kō. ʻO ka mea nui, ʻo ka ʻai maikaʻi a ʻai maikaʻi.
Alexandra, 51
ʻAe ʻia i ka lāʻau lapaʻau i hōʻike ʻia e ka lāʻau lapaʻau. Loaʻa kona kumukūʻai mai 440-580 rubles. ʻO ke kumu kūʻai o nā ʻāpana ʻē aʻe mai 82 a 423 mau rubles.
