ʻO nā ʻano maʻi maʻi āpau 2 no 90% o nā ʻano maʻi āpau. Ma ka lima like, pale aku ka insulin i nā ʻolua e pane maʻamau i ka insulin. Ma ka lima ʻē aʻe, aia kahi β-cell dysfunction: mai kahi kue ʻole i ka palaka e hoʻopau i ka make, a ma ka maʻi diabetes hoʻi hoʻemi ʻia ka nui o kā lākou huina e 63% (i nā mea ʻala - nā hapalua haʻahaʻa). ʻAʻole hiki kēia i nā mea ke hoʻopiha i ke kino e hoʻopiha i ka pono o ka hormone i mea e lanakila ai i ka pale ʻana i ka insulin.
E uhaʻi i kēia pōkole ʻino, nui nā lāʻau lapaʻau i kūkulu ʻia no ka mākaʻi glycemic. ʻO ka Biguanides a me ka thiazolidinediones ka hakakā me ka pale ʻana i ka insulin, ka sulfonylureas a me nā palapala lepo hoʻihoʻi i ka synthesis o ka insulin endogenous, Acarbose a me Glucobay paʻa i ka hoʻopio ʻana o ka glucose i loko o ka ʻōpū, akā, ma ka hoʻopiʻi ʻana, aia nō kekahi hopena palekana. Ma keʻano pilikino, ʻo ka hapa nui o lākou e pili pono i ka paona o ke kino, ʻoiai ʻo ka hapaha ke kumu nui o ka maʻi diabetes.
ʻO ka hanauna hou o nā lāʻau lapaʻau ke ʻano hōʻuluʻulu o nā lāʻau lapaʻau. Inhibitor DPP-4 Januvia (inoa inoa honua - Sitagliptin, Januvia, Sitagliptin) kūʻokoʻa e nānā i kēia mea - e hōʻemi ana i ka makemake, a me ka manawa - a me ke kaumaha, a ʻaʻole wale kēia wale nō kāna pono.
Ma luna o 10 mau makahiki o ka hana lapaʻau, ua hoʻopili ʻia kahi mea hōʻike kūpono o kāna pono.
Ka helu ʻana a me ka helu ʻana
Janucius incretin mimetic, ke kiʻi o ka mea i hōʻike ʻia ma kēia ʻāpana, hoʻomohala ʻia ma ka kumu o ka sitagliptin, i hōʻike ʻia ma ke ʻano o ka phosphate monohydrate. Hoʻohana ʻia i nā papa o nā ʻano like ʻole a me nā hoʻopiha: magnesium, microcrystalline cellulose, sodium, calcium hydrogen phosphate.
Hiki i ka maʻi maʻi ke hoʻokaʻawale i nā hewa o ka lāʻau i ka kala: me ka liʻiliʻi liʻiliʻi - pink, me ka nui - beige. Wahi a ke kaupaona, ua hōʻailona ʻia nā papa: "221" - ʻomaʻomaʻo 25 mg, "112" - 50 mg, "277" - 100 mg. Hoʻopili ʻia ka lāʻau lapaʻau i nā kāla blister. Aia paha he nui nā kōpala ma kēlā me kēia pahu.
I ka hoʻoponopono wela a hiki i ka 30 ° C, hiki ke mālama i ka lāʻau lapaʻau i loko o ka manawa hōʻoia.
Pehea e hana ai ʻoviavia
ʻO kahi lāʻau lapaʻau hypoglycemic synthetic is the group of incretin mimetics that inhibit DPP-4. Hoʻohana pinepine ka hana ʻo Januvia i ka hana ʻana o nā incretins, e hoʻoikaika ai i ka hana. Hoʻonui ka hana o ka insulin endogenous, ke paʻa ka hoʻopili ʻana o ka glucagon ma ke akea.
Mālama ka hoʻokele Oral i ka wāwahi o ka glucagon-like peptide GLP-1, he hana koʻikoʻi i ke kau ʻana o ka glucose i hilinaʻi i ka glucose, a hoʻihoʻi hou i kāna mau kūlohelohe. Hāʻawi kēia hoʻonohonoho i nā hana i ka maʻamau o ka glycemia.
Kōkua ka sitagliptin i ka hoʻēmi ʻana i ka hemoglobin glycated, ka wikiwiki o ka wikiwiki, a me ke kaumaha o ke kino. Mai ka hāwele ʻana, komo ka lāʻau i loko o ke kahe koko i loko o nā hola 1-4. ʻO ka manawa nānā aku a me ka helu caloric o ka meaʻai ʻaʻole i hoʻopilikia i ka pharmacokinetics o ka mea pale.
Ua kūpono kēia lāʻau lapaʻau no ka hoʻokele ʻana i kēlā me kēia manawa: ma mua, ma hope o ka wā a me ka wā o ka ʻai. Aʻo 80% o ka wai ikaika e hoʻopā ʻia e nā keiki. Hiki i ka lāʻau lapaʻau ke hoʻohana ʻia ma ka monotherapy a ma ka mālama ʻia ʻana o ka maʻi maʻi diabetes type 2, ʻoi aku hoʻi me ka hoʻonui pinepine ʻana o nā hōʻemi hypoglycemic.
Ma ka papa hana maʻamau, ua hoʻonui ʻia ʻo Januvia e Metformin, kahiʻai ʻai haʻahaʻa a me ka hana kino dosed.
Hiki iā ʻoe ke ʻike i ka ka hopena o ka hopena o ka lāʻau lapaʻau ma kēia wikiō.
I hōʻike ʻia no ka lāʻau lapaʻau
Ua kuhikuhi ʻia ʻo Januvia no ka maʻi type o ka maʻi 2 i nā manawa like ʻole o ka hoʻokele maʻi.
Ke hui pū ʻia me nā ʻano lāʻau lapaʻaka hypoglycemic ʻē aʻe, ua kuhikuhi ʻia ʻo Januvia:
- Hoʻohui iā Metformin, inā ʻaʻole i lawe mai ka loli hoʻololi i ka hopena i manaʻo ʻia;
- Me nā hua paʻi o ka hui sulfonylurea - Euglucan, Daonil, Diabeton, Amaril, inā ʻaʻole maikaʻi ka hopena o ka ʻaina ma mua a i ʻole ka mea maʻi e ʻae aku i ka Metformin;
- Ka ʻokoʻa ʻana me ka thiazolidinediones - Pioglitazan, Rosiglitazone, inā kūpono kēlā hui.
I ka lāʻau hoʻokau triple, ua hui pū ʻia ʻo Januvius:
- Me Metformin, derivatives o sulfonylurea, nā kai ʻai haʻahaʻa, a me ke kau ʻana, inā ʻaʻole ʻo Januvia i hiki ʻole ke hoʻokō he 100% glycemic control;
- Ma ka manawa like ʻo Metformin a me thiazolidinediones, ʻo PPARy antagonist, inā inā ʻaʻole i lawa ka maikaʻi o nā alualu ʻana i ka maʻi maʻi.
Hiki ke hoʻohana iā Januvia i ka hoʻohui ʻana i ka lāʻau lapaʻau inā i mālama ʻia ka lāʻau i ka pilikia o ka pale ʻana i ka insulin.
ʻAʻole pono e wae ʻia ka sitagliptin
Me nā maʻi 'āpau 1 a me nā maʻi kū i nā mea kanu o ka hoʻopalike, ua contraindicated ʻo Januvia. Mai kuhikuhi i ke lāʻau lapaʻau: 
- Nā makuahine hāpai a me ka lactating;
- Me ka ketoacidosis maʻi maʻi;
- I ke wā kamaliʻi.
ʻO nā mea maʻi me nā ala poloka me ke koho ʻana iā Januvia e hoʻonui nui ʻia. Ma ke ʻano paʻakikī, ʻoi aku ka maikaʻi o ke koho i nā analogues no ka mālama maʻi. ʻO ka maʻi ma luna o ka hemodialysis e kiaʻi mau ai hoʻi.
ʻO ka hikiʻole o nā hoʻopiʻi
I ka hihia o ka overdose, hypersensitivity, ka hoʻoponopono regtion i koho ʻia ʻole, ʻike ʻia nā hopena e like me ke ʻano nui o nā maʻi concomitant i loaʻa a i ʻole ka hoʻomohala ʻana o nā mea hou. Hiki ke ʻano kēlā mau hanana i ka hopena o ka hoʻopulapula a me kahi mea hoʻoneʻe i loaʻa i ka maʻi maʻi maʻi.
I waena o nā hoʻopiʻi o ka maʻi maʻi, aia nā huaʻi maʻi (ketoacidosis diabetes), precoma a me ka glycemic coma) a me nā maʻi - angiopathy, neuropathy, retinopathy, nephropathy, encephalopathy, etc. A ʻo Retinopathy ke kumu kumu o ka makapō i ka maʻi maʻi: ma United States - 24 mano mau hihia hou i kēlā me kēia makahiki. ʻO Nepropathy ka pono mua no ka hana ʻole o ka renal - 44% o nā hihia i kēlā me kēia makahiki, ʻo ka neuropathy ke kumu nui o nā hana hōʻeha o ka traumatic o nā hopena (60% o nā hihia hou i kēlā me kēia makahiki).
Inā ʻaʻole i ukali ʻia nā ʻōlelo a ke kauka e pili ana i ka dosis a me ka manawa e komo ai.
ʻO nā hopena ʻē aʻe, nāwaliwali o ka ʻōnaehana pale maʻamau e kū pinepine, i hele pū me ka ʻeha o ka hanu.
E pili ana i ka lāʻau lapaʻau i ka loiloi i ka loiloi, hoʻopiʻi ka maʻi maʻi i nā hōʻeha a me nā hāʻule o ke koko. I nā hoʻokolokolo, hiki ke hoʻonui iki ʻia ka helu leukocyte, akā ʻaʻole manaʻo nā kauka i kēia pae he koʻikoʻi. ʻAʻohe pilina kūpono ma waena o ka lawe ʻana i ka lāʻau lapaʻau a me ka hoʻomohala ʻana o ka pancreatitis.
- ʻeha nā pīhoihoi o ka naʻau
- maʻi ʻeha hanu
- ʻumiina
- nā huakaʻi dyspeptic
Me ka hoʻohana mau ʻana o ka sitagliptin, hiki ke hoʻopau ʻia mai ka naʻau, nā kīʻaha koko, a me ke ʻano. Pono e hoʻomaopopo ʻia kahi maʻi maʻi e pili ana i ka pono e kipa i kahi kauka inā he loli ma ke ʻano o ke koko a i ʻole ka puʻuwai puʻuwai ma ke lawe ʻana iā Januvia.
ʻAʻohe mau hihia i hoʻohui i ka lāʻau lapaʻau ma ka hoʻomaʻamaʻa ʻana i ka hana lapaʻau; me ka loli ʻole o ka loli ʻana, ke hiki wale nō ka haʻahaʻa haʻahaʻa.
Nā hihia keu
He lāʻau lapaʻau koʻikoʻi ʻo Januvia, a ʻo ka hana paʻa loa i nā ʻōlelo ʻana o ka endocrinologist ke kūlana nui no kona hana pono. ʻO ka helu palekana hoʻomaka sitagliptin he 80 mg.
Ua lawe ʻia nā haʻawina e pili ana i nā hopena o ka make overdose me kahi hoʻonui pākahi o ka hopena i kēia hopena.
Inā ulu kahi hōʻeha hypoglycemic, e hoʻopiʻi ka mea pōpilikia, kahi palupalu, nāwaliwali, nā maʻi dyspeptic, hopohopo o ka maikaʻi o ka maikaʻi, pono ia e holoi i ka ʻōpū, hāʻawi i ka mea maʻi i nā mea laʻa. E hoʻokō ʻia ka maʻi maʻi maʻi ma loko o ka haukapila maʻi.
Hoʻokomo pinepine ʻia nā hihia o ka overdose. Hoʻohui pinepine kēia i ka intolerance pilikino a i ʻole nā hopena o nā lāʻau lapaʻau ʻē aʻe i hoʻohanaʻia i ka hoʻomaʻamaʻa paʻakikī.
ʻAʻole maikaʻi ʻo Hemodialysis o Januvia. No 4 mau hola, ʻoi aku ka lōʻihi o ke kaʻina hana, ma hope o ka lawe ʻana i hoʻokahi kope hoʻokahi, ʻo 13% wale nō ka lāʻau lapaʻau i hoʻokuʻu ʻia.
Loaʻa nā kūlana o Januvia me ka mālama paʻakikī
ʻAʻole ʻo Sitagliptin e kāohi i ka hana a Simvastatin, Warfarin, Metformin, Rosiglitazone. Hiki ke hoʻohana ʻia ʻo Januvia e nā wahine i hoʻohana pinepine ʻia ai i nā contraceptives waha. Hoʻonui iki i ka hoʻokele ʻo concurrent me Dioxin i nā hiki o nā mea hope aʻe, akā ʻaʻole ia e koi i nā loli i ka hoʻoponopono ʻia.
Hiki ke hoʻohana ʻo Januvia i ka hui pū me ka cyclosporine a i ʻole nā mea pale (e like me ke ketoconazole). ʻAʻole hopena ka hopena o ka sitagliptin i kēia mau hihia a ʻaʻole hoʻololi i nā kūlana no ka lawe ʻana i ka lāʻau lapaʻau.
Nā manaʻo e hoʻohana
No ka lāʻau lapaʻau o Iovia, ua huki ʻia nā ʻōlelo e pili ana i ka hoʻohana ʻana i nā kikoʻī, a pono e aʻo ʻia ma mua o ka hoʻomaka ʻana o ka papa o ka mālama ʻana.
Inā pau ka manawa hoʻonā, pono ka inu o ka lāʻau lapaʻau i ka manawa mua. Ma ka manawa like, hopohopo ke kānalua nei ka maʻamau, no ka mea he pono i kēlā me kēia lā o ka manawa ma waena o nā āpana.
ʻO ka paʻu maʻamau o Januvia ʻo 100 mg / lā. In pathal pathologies of light to moderate Severity, i kuhikuhi ʻia ʻo 50 mg / lā. Inā holomua ka maʻi a lilo i ka pilikia, hoʻoponopono ʻia ke ʻano me 25 mg / lā. Inā hoʻohana ʻia ka lāʻau lapaʻau i hui pū me nā lāʻau lapaʻau e hoʻohaʻahaʻa i nā wai, pono e hōʻemi ʻia nā nui o ka insulin a me nā papa e pale aku i ka hypoglycemia.
Inā pono, lawe ʻia ka dialysis, ʻoiai ke kuhikuhi ʻana i ka nui ma ka liʻiliʻi. ^ E Ha yM. ʻO ka manawa e loaʻa iā Januvia i paʻa ʻole i ka manawa o ke kaʻina hana. I ka wā pākeke (mai nā makahiki 65) hiki i nā mea maʻi ke hoʻohana i ka lāʻau lapaʻau me ka ʻole o nā mea i kaupalena ʻia ʻē aʻe, inā ʻaʻole mau mau pilikia mai nā keiki. I ka hihia hope loa, pono ʻia kahi hoʻoponopono hoʻoponopono ʻia.
Nā manaʻo loea
Hiki ke kūʻai ʻia ʻo Yanuvia ma ke kahua lāʻau lapaʻau wale nō me kahi kumu kūkala. ^ E Ha yM. ʻO ka hypoglycemia, e like me nā haʻawina, me ka mālama ʻana i nā ʻōnaehana paʻakikī ʻaʻole maʻamau maʻamau ma mua o ka placebo. ʻAʻole i aʻo ʻia ka hopena ma ke kino o Januvia i ka hope o nā dosis nui o ka insulin, no laila ua kaupalena ʻia nā mea maʻi ma ka hoʻokele hypoglycemic.
ʻO ka hopena maikaʻi o ka lāʻau lapaʻau ma luna o ka hiki ke mālama i ka halihali a i ʻole nā mea i hoʻopihapiha ʻole ʻia.
ʻO ka hypersensitivity i ka wā e lawe ai iā Januvia i hiki ke hōʻike ʻia ma ka pīhoihoi anaphylactic. Nā helehelena maka o ka mea i make, ʻike ʻia ka ʻili o ka ʻili. Ma nā hihia koʻikoʻi, nānā ʻia ka edema o Quincke. Me kēlā mau ʻōuli, ua hoʻokuʻu koke ʻia ka lāʻau lapaʻau a ʻimi i ke kōkua olakino.
Hoʻohana ʻia ʻo Januvia i loko o ka paʻakikī paʻakikī i ka haʻalele ʻana o nā hopena i makemake ʻia ma hope o ka lawe ʻana i ka Metformin a me nā ʻano hana. Hiki iā ʻoe ke hoʻohana i ka lāʻau lapaʻau i ka wā e hoʻololi ai i ka insulin.
Hōʻikeʻike e pili ana iā Januvia
Me ka holomua o ka papa diabetes 2 me ka papaʻa ʻana i ke kō.
He mea nui hoʻi ia e loaʻa i kāu lāʻau ponoʻī e kōkua i ka mālama ʻana i kahi maʻi maʻi ʻole me ka hoʻopili ʻana i nā pilikia hou i ka maʻi maʻi.
Ke koho nei i kahi lāʻau lapaʻau hypoglycemic kūpono no ka hoʻohuihui maʻi ʻana, e nānā ka poʻe loea i nā mea hiki ke nānā aku a me ka hiki ʻole o ka glycemic. Ma ka hihia mua, he hōʻemi kēia i ka hemoglobin glycated, ka nui i hoʻoweliweli ʻia o ka hypoglycemia, huna ʻana o ka insulin, a me kahi pānaʻi palekana. Ma ka lua - nā loli i ke koʻikoʻi o ke kino, nā maʻi pilikia HF, ka hoʻomanawanui, ka ʻike palekana, ka hiki ʻana, ke kumu, ka maʻalahi o ka hoʻohana.
E pili ana i ka lāʻau lapaʻau loiloi review loea o nā kauka: kokoke ka pili i ka glycemia kokoke i nā pae kūlohelohe maʻamau, postprandial i ka wā ʻaʻole eʻoi aku ka ʻai i ka palena, ʻaʻole mālama ʻia nā kuʻuna o ke kō, ʻike maikaʻi ka lāʻau lapaʻau a ikaika a hoʻokō pono i nā kūpaʻa. Hōʻailona iā Profesor A.S. Ametova, poʻo. Ke Keʻena ʻO Endocrinology a me Diabetology GBOU DPO RMAPE o ke Keʻena Oihana Ola o ka Lūkini Lūkini, e pili ana i nā hiki o sitagliptin, e nānā i ke wikiō:
Hoʻohui ʻia nā loiloi o nā mea maʻi e lawe ana iā Januvia.
A.I. Ua hala wau ma Metformin no 3 mau makahiki i hala, ʻaʻole makemake ke kauka i nā hoʻokolohua hope loa, ua kuhikuhi pū aku au iā Januvia. Ua inu paha wau i hoʻokahi papa no hoʻokahi mahina. ʻ saidlelo ke kauka hiki iā ʻoe ke inu i kēlā me kēia manawa, akā maikaʻi iaʻu i ke kakahiaka. A pono e hana ka lāʻau lapaʻau, ʻokoʻa i mua o ke ao, i ka nui o ka hoʻouka ʻana ma ke kino. ʻAʻole wau i ʻike i kekahi mau ʻaoʻao ʻaoʻao, ʻoiai e mālama ana i ka hilo.
T.O. ʻO kahi hoʻopaʻapaʻa koʻikoʻi i nā hoʻokolohua ma koʻu olakino ke kumukūʻai o ka mālama. No ʻOvia, ʻaʻole ke kumukūʻai ʻo ke kumukūʻai: ua kūʻai au i 28 mau papa o 100 mg no 1675 rubles. Ua lawa iaʻu kahi kumukūʻai no hoʻokahi mahina. He kūpono ka lāʻau lapaʻau, ʻoi ke koko ka mea maʻamau, akā pono wau e kūʻai i nā pōpoki ʻē aʻe, no laila ke noʻonoʻo nei i kaʻu penikala e noi au i ke kauka no kahi mea e pono ai. Malia paha e haʻi aku i ka hoʻohālike māmā?
ʻO nā hoʻohālikelike hoʻohālikelike o Ianvia
Inā mākou e hoʻohālikelike i nā lāʻau lapaʻau e like me ke code ATX 4, a laila ma kahi o Januvia, hiki iā ʻoe ke koho i nā analogues.
- ʻOnglise me ka mea hoʻohana ikaika i ka saxagliptin;
- ʻO Galvus, kūkulu ʻia ma ka kumu o vildagliptin;
- Galvus Met - vildagliptin i hui pū me ka metformin;
- Trazentu me ka linagliptin waiwai ikaika;
- Combogliz Prolong - e pili ana i ka metformin a me saxagliptin;
- Nesinu me ka alogliptin ʻano hana.
Hoʻohālikelike ka ʻano o ke ʻano o nā lāʻau lapaʻau: ke kāohi nei lākou i ka makemake, ʻaʻole e hoʻokaʻawale i ke kikowaena kūloko a me ka ʻōnaehana cardiovascular. Inā ʻoe e hoʻohālikelike i nā mea hoʻohālike me Yanuvia ma kekahi kumukūʻai, a laila hiki iā ʻoe ke loaʻa mei aku ka maʻalahi: no nā papa 30 o Galvus Meta me ka papa like like, pono ʻoe e uku i ka 1,448 rubles, no 28 mau kihi o Galvus - 841 rubles. E ʻoi aku ka uku o Onlisa: 1978 mau rubles no 30 pcs. Ma nā ʻāpana like a me Trazhenta: 1866 mau rubles. no 30 papa. ʻO ka mea kūʻai nui loa ma kēia papa inoa, ʻo ia ʻo Combogliz Prolong: 2863 rubles. no 30 pcs.
Inā ʻaʻole hiki ke hoʻokō ʻia ka uku uku ma ka liʻiliʻi o nā lāʻau antidiabetic, hiki iā ʻoe ke koho i kahi koho e like me kāu kauka.
I kēia lā, ʻo ka maʻi diabetes type 2 ʻaʻole ia he mea paʻakikī i kahi ola piha. Loaʻa i ka maʻi diabetes kona hoʻohana ʻana i nā lāʻau lapaʻau hou o nā ʻano like ʻole o nā pehu, nā mea olakino e pili ana i ka lawelawe ʻana i nā lāʻau lapaʻau a me ka mālama pono ʻana i ka glycemia nānā pono. Ua hoʻokumu ʻia nā kula o nā maʻi maʻi i nā keʻena olakino a me nā sanatoriums, a aia nā ʻike āpau e pono ai ka Pūnaewele.
ʻO Januvius kahi pā hou e hoʻhoihoi ai no ka mālama ʻana i ka maʻi type 2 a i ʻole he mea ʻepekema noiʻi.
